File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Prevalence and risk factors for impaired renal function among Asian patients with nonalcoholic fatty liver disease

TitlePrevalence and risk factors for impaired renal function among Asian patients with nonalcoholic fatty liver disease
Authors
Sun, ChaoGoh, George Boon BeeChow, Wan ChengChan, Wah KheongWong, Grace Lai HungSeto, Wai KayHuang, Yi HsiangLin, Han ChiehLee, I ChengLee, Hye WonKim, Seung UpWong, Vincent Wai SunFan, Jian Gao
Issue Date31-Jul-2023
PublisherElsevier
Citation
Hepatobiliary and Pancreatic Diseases International, 2023 How to Cite?
DOI: http://dx.doi.org/10.1016/j.hbpd.2023.08.004
Abstract

Background

Nonalcoholic fatty liver disease (NAFLD) is associated with impaired renal function, and both diseases often occur alongside other metabolic disorders. However, the prevalence and risk factors for impaired renal function in patients with NAFLD remain unclear. The objective of this study was to identify the prevalence and risk factors for renal impairment in NAFLD patients.

Methods

All adults aged 18-70 years with ultrasound-diagnosed NAFLD and transient elastography examination from eight Asian centers were enrolled in this prospective study. Liver fibrosis and cirrhosis were assessed by FibroScan-aspartate aminotransferase (FAST), Agile 3+ and Agile 4 scores. Impaired renal function and chronic kidney disease (CKD) were defined by an estimated glomerular filtration rate (eGFR) with value of < 90 mL/min/1.73 m2 and < 60 mL/min/1.73 m2, respectively, as estimated by the CKD-Epidemiology Collaboration (CKD-EPI) equation.

Results

Among 529 included NAFLD patients, the prevalence rates of impaired renal function and CKD were 37.4% and 4.9%, respectively. In multivariate analysis, a moderate-high risk of advanced liver fibrosis and cirrhosis according to Agile3+ and Agile 4 scores were independent risk factors for CKD (P < 0.05). Furthermore, increased fasting plasma glucose (FPG) and blood pressure were significantly associated with impaired renal function after controlling for the other components of metabolic syndrome (P < 0.05). Compared with patients with normoglycemia, those with prediabetes [FPG ≥ 5.6 mmol/L or hemoglobin A1c (HbA1c) ≥ 5.7%] were more likely to have impaired renal function (P < 0.05).

Conclusions

Agile 3+ and Agile 4 are reliable for identifying NAFLD patients with high risk of CKD. Early glycemic control in the prediabetic stage might have a potential renoprotective role in these patients.


Persistent Identifierhttp://hdl.handle.net/10722/331159
ISSN
1499-3872
2023 Impact Factor: 3.6
2023 SCImago Journal Rankings: 0.720

 

DC FieldValueLanguage
dc.contributor.authorSun, Chao-
dc.contributor.authorGoh, George Boon Bee-
dc.contributor.authorChow, Wan Cheng-
dc.contributor.authorChan, Wah Kheong-
dc.contributor.authorWong, Grace Lai Hung-
dc.contributor.authorSeto, Wai Kay-
dc.contributor.authorHuang, Yi Hsiang-
dc.contributor.authorLin, Han Chieh-
dc.contributor.authorLee, I Cheng-
dc.contributor.authorLee, Hye Won-
dc.contributor.authorKim, Seung Up-
dc.contributor.authorWong, Vincent Wai Sun-
dc.contributor.authorFan, Jian Gao-
dc.date.accessioned2023-09-21T06:53:15Z-
dc.date.available2023-09-21T06:53:15Z-
dc.date.issued2023-07-31-
dc.identifier.citationHepatobiliary and Pancreatic Diseases International, 2023-
dc.identifier.issn1499-3872-
dc.identifier.urihttp://hdl.handle.net/10722/331159-
dc.description.abstract<h3>Background</h3><p>Nonalcoholic fatty liver disease (NAFLD) is associated with impaired renal function, and both diseases often occur alongside other metabolic disorders. However, the prevalence and risk factors for impaired renal function in patients with NAFLD remain unclear. The objective of this study was to identify the prevalence and risk factors for renal impairment in NAFLD patients.</p><h3>Methods</h3><p>All adults aged 18-70 years with ultrasound-diagnosed NAFLD and transient elastography examination from eight Asian centers were enrolled in this prospective study. Liver fibrosis and cirrhosis were assessed by FibroScan-aspartate aminotransferase (FAST), Agile 3+ and Agile 4 scores. Impaired renal function and chronic kidney disease (CKD) were defined by an estimated glomerular filtration rate (eGFR) with value of < 90 mL/min/1.73 m<sup>2</sup> and < 60 mL/min/1.73 m<sup>2</sup>, respectively, as estimated by the CKD-Epidemiology Collaboration (CKD-EPI) equation.</p><h3>Results</h3><p>Among 529 included NAFLD patients, the prevalence rates of impaired renal function and CKD were 37.4% and 4.9%, respectively. In multivariate analysis, a moderate-high risk of advanced liver fibrosis and cirrhosis according to Agile3+ and Agile 4 scores were independent risk factors for CKD (<em>P</em> < 0.05). Furthermore, increased fasting plasma glucose (FPG) and blood pressure were significantly associated with impaired renal function after controlling for the other components of metabolic syndrome (<em>P</em> < 0.05). Compared with patients with normoglycemia, those with prediabetes [FPG ≥ 5.6 mmol/L or hemoglobin A1c (HbA1c) ≥ 5.7%] were more likely to have impaired renal function (<em>P</em> < 0.05).</p><h3>Conclusions</h3><p>Agile 3+ and Agile 4 are reliable for identifying NAFLD patients with high risk of CKD. Early glycemic control in the prediabetic stage might have a potential renoprotective role in these patients.</p>-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofHepatobiliary and Pancreatic Diseases International-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titlePrevalence and risk factors for impaired renal function among Asian patients with nonalcoholic fatty liver disease-
dc.typeArticle-
dc.identifier.doi10.1016/j.hbpd.2023.08.004-
dc.identifier.eissn2352-9377-
dc.identifier.issnl2352-9377-

Export via OAI-PMH Interface in XML Formats

OR

Export to Other Non-XML Formats