File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Impact of neoadjuvant chemotherapy on the difficulty and outcomes of laparoscopic and robotic major liver resections for colorectal liver metastases: A propensity-score and coarsened exact-matched controlled study

TitleImpact of neoadjuvant chemotherapy on the difficulty and outcomes of laparoscopic and robotic major liver resections for colorectal liver metastases: A propensity-score and coarsened exact-matched controlled study
Authors
KeywordsDifficulty
Laparoscopic liver resections
Major resections
Neoadjuvant chemotherapy
Robotic liver resections
Issue Date20-Jan-2023
PublisherElsevier
Citation
European Journal of Surgical Oncology, 2023, v. 49, n. 7, p. 1209-1216 How to Cite?
Abstract

Background: Minimal invasive liver resections are a safe alternative to open surgery. Different scoring systems considering different risks factors have been developed to predict the risks associated with these procedures, especially challenging major liver resections (MLR). However, the impact of neoadjuvant chemotherapy (NAT) on the difficulty of minimally invasive MLRs remains poorly investigated. Methods: Patients who underwent laparoscopic and robotic MLRs for colorectal liver metastases (CRLM) performed across 57 centers between January 2005 to December 2021 were included in this analysis. Patients who did or did not receive NAT were matched based on 1:1 coarsened exact and 1:2 propensity-score matching. Pre- and post-matching comparisons were performed. Results: In total, the data of 5189 patients were reviewed. Of these, 1411 procedures were performed for CRLM, and 1061 cases met the inclusion criteria. After excluding 27 cases with missing data on NAT, 1034 patients (NAT: n = 641; non-NAT: n = 393) were included. Before matching, baseline characteristics were vastly different. Before matching, the morbidity rate was significantly higher in the NAT-group (33.2% vs. 27.2%, p-value = 0.043). No significant differences were seen in perioperative outcomes after the coarsened exact matching. After the propensity-score matching, statistically significant higher blood loss (mean, 300 (SD 128–596) vs. 250 (SD 100–400) ml, p-value = 0.047) but shorter hospital stay (mean, 6 [4-8] vs. 6 [5-9] days, p-value = 0.043) were found in the NAT-group. Conclusion: The current study demonstrated that NAT had minimal impact on the difficulty and outcomes of minimally-invasive MLR for CRLM.


Persistent Identifierhttp://hdl.handle.net/10722/331233
ISSN
2023 Impact Factor: 3.5
2023 SCImago Journal Rankings: 1.164
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGhotbi, J-
dc.contributor.authorAghayan, D-
dc.contributor.authorFretland, Å-
dc.contributor.authorEdwin, B-
dc.contributor.authorSyn, NL-
dc.contributor.authorCipriani, F-
dc.contributor.authorAlzoubi, M-
dc.contributor.authorLim, C-
dc.contributor.authorScatton, O-
dc.contributor.authorLong, TCD-
dc.contributor.authorHerman, P-
dc.contributor.authorCoelho, FF-
dc.contributor.authorMarino, MV-
dc.contributor.authorMazzaferro, V-
dc.contributor.authorChiow, AKH-
dc.contributor.authorSucandy, I-
dc.contributor.authorIvanecz, A-
dc.contributor.authorChoi, SH-
dc.contributor.authorLee, JH-
dc.contributor.authorPrieto, M-
dc.contributor.authorVivarelli, M-
dc.contributor.authorGiuliante, F-
dc.contributor.authorRuzzenente, A-
dc.contributor.authorYong, CC-
dc.contributor.authorYin, M-
dc.contributor.authorFondevila, C-
dc.contributor.authorEfanov, M-
dc.contributor.authorMorise, Z-
dc.contributor.authorDi, Benedetto, F-
dc.contributor.authorBrustia, R-
dc.contributor.authorDalla, Valle, R-
dc.contributor.authorBoggi, U-
dc.contributor.authorGeller, D-
dc.contributor.authorBelli, A-
dc.contributor.authorMemeo, R-
dc.contributor.authorMejia, A-
dc.contributor.authorPark, JO-
dc.contributor.authorRotellar, F-
dc.contributor.authorChoi, GH-
dc.contributor.authorRobles-Campos, R-
dc.contributor.authorWang, X-
dc.contributor.authorSutcliffe, RP-
dc.contributor.authorPratschke, J-
dc.contributor.authorTang, CN-
dc.contributor.authorChong, CCN-
dc.contributor.authorD'Hondt, M-
dc.contributor.authorMonden, K-
dc.contributor.authorLopez-Ben, S-
dc.contributor.authorKingham, TP-
dc.contributor.authorFerrero, A-
dc.contributor.authorEttorre, GM-
dc.contributor.authorLevi, Sandri, GB-
dc.contributor.authorPascual, F-
dc.contributor.authorCherqui, D-
dc.contributor.authorLiang, X-
dc.contributor.authorMazzotta, A-
dc.contributor.authorWakabayashi, G-
dc.contributor.authorGiglio, M-
dc.contributor.authorTroisi, RI-
dc.contributor.authorHan, HS-
dc.contributor.authorCheung, TT-
dc.contributor.authorSugioka, A-
dc.contributor.authorChen, KH-
dc.contributor.authorLiu, R-
dc.contributor.authorSoubrane, O-
dc.contributor.authorFuks, D-
dc.contributor.authorAldrighetti, L-
dc.contributor.authorAbu, Hilal, M-
dc.contributor.authorGoh, BKP-
dc.date.accessioned2023-09-21T06:53:55Z-
dc.date.available2023-09-21T06:53:55Z-
dc.date.issued2023-01-20-
dc.identifier.citationEuropean Journal of Surgical Oncology, 2023, v. 49, n. 7, p. 1209-1216-
dc.identifier.issn0748-7983-
dc.identifier.urihttp://hdl.handle.net/10722/331233-
dc.description.abstract<p>Background: Minimal invasive liver resections are a safe alternative to open surgery. Different scoring systems considering different risks factors have been developed to predict the risks associated with these procedures, especially challenging major liver resections (MLR). However, the impact of neoadjuvant chemotherapy (NAT) on the difficulty of minimally invasive MLRs remains poorly investigated. Methods: Patients who underwent laparoscopic and robotic MLRs for colorectal liver metastases (CRLM) performed across 57 centers between January 2005 to December 2021 were included in this analysis. Patients who did or did not receive NAT were matched based on 1:1 coarsened exact and 1:2 propensity-score matching. Pre- and post-matching comparisons were performed. Results: In total, the data of 5189 patients were reviewed. Of these, 1411 procedures were performed for CRLM, and 1061 cases met the inclusion criteria. After excluding 27 cases with missing data on NAT, 1034 patients (NAT: n = 641; non-NAT: n = 393) were included. Before matching, baseline characteristics were vastly different. Before matching, the morbidity rate was significantly higher in the NAT-group (33.2% vs. 27.2%, p-value = 0.043). No significant differences were seen in perioperative outcomes after the coarsened exact matching. After the propensity-score matching, statistically significant higher blood loss (mean, 300 (SD 128–596) vs. 250 (SD 100–400) ml, p-value = 0.047) but shorter hospital stay (mean, 6 [4-8] vs. 6 [5-9] days, p-value = 0.043) were found in the NAT-group. Conclusion: The current study demonstrated that NAT had minimal impact on the difficulty and outcomes of minimally-invasive MLR for CRLM.</p>-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofEuropean Journal of Surgical Oncology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectDifficulty-
dc.subjectLaparoscopic liver resections-
dc.subjectMajor resections-
dc.subjectNeoadjuvant chemotherapy-
dc.subjectRobotic liver resections-
dc.titleImpact of neoadjuvant chemotherapy on the difficulty and outcomes of laparoscopic and robotic major liver resections for colorectal liver metastases: A propensity-score and coarsened exact-matched controlled study-
dc.typeArticle-
dc.identifier.doi10.1016/j.ejso.2023.01.014-
dc.identifier.scopuseid_2-s2.0-85149804350-
dc.identifier.volume49-
dc.identifier.issue7-
dc.identifier.spage1209-
dc.identifier.epage1216-
dc.identifier.eissn0748-7983-
dc.identifier.isiWOS:001026381300001-
dc.identifier.issnl0748-7983-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats