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Article: An update on the role of complement in hepatocellular carcinoma.

TitleAn update on the role of complement in hepatocellular carcinoma.
Authors
Keywordscomplement
hepatocellular carcinoma
metastasis
stemness
tumour microenvironment
tumourigenesis
Issue Date31-Dec-2022
PublisherFrontiers Media
Citation
Frontiers in Immunology, 2022, v. 13 How to Cite?
AbstractAs a main producer of complement, the environment in the liver is greatly affected by the complement system. Although the complement system is considered to have the ability of nonself discrimination, remarkable studies have revealed the tight association between improper complement activation in tumour initiation and progression. As complement activation predominantly occurs within the liver, the protumourigenic role of the complement system may contribute to the development of hepatocellular carcinoma (HCC). Improvement in the understanding of the molecular targets involved in complement-mediated tumour development, metastasis, and tumour-promoting inflammation in HCC would certainly aid in the development of better treatments. This minireview is focused on recent findings of the protumourigenic role of the complement system in HCC.
Persistent Identifierhttp://hdl.handle.net/10722/331273
ISSN
2023 Impact Factor: 5.7
2023 SCImago Journal Rankings: 1.868
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXiao, Z-
dc.contributor.authorYeung, CLS-
dc.contributor.authorYam, JWP-
dc.contributor.authorMao, X-
dc.date.accessioned2023-09-21T06:54:15Z-
dc.date.available2023-09-21T06:54:15Z-
dc.date.issued2022-12-31-
dc.identifier.citationFrontiers in Immunology, 2022, v. 13-
dc.identifier.issn1664-3224-
dc.identifier.urihttp://hdl.handle.net/10722/331273-
dc.description.abstractAs a main producer of complement, the environment in the liver is greatly affected by the complement system. Although the complement system is considered to have the ability of nonself discrimination, remarkable studies have revealed the tight association between improper complement activation in tumour initiation and progression. As complement activation predominantly occurs within the liver, the protumourigenic role of the complement system may contribute to the development of hepatocellular carcinoma (HCC). Improvement in the understanding of the molecular targets involved in complement-mediated tumour development, metastasis, and tumour-promoting inflammation in HCC would certainly aid in the development of better treatments. This minireview is focused on recent findings of the protumourigenic role of the complement system in HCC.-
dc.languageeng-
dc.publisherFrontiers Media-
dc.relation.ispartofFrontiers in Immunology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectcomplement-
dc.subjecthepatocellular carcinoma-
dc.subjectmetastasis-
dc.subjectstemness-
dc.subjecttumour microenvironment-
dc.subjecttumourigenesis-
dc.titleAn update on the role of complement in hepatocellular carcinoma.-
dc.typeArticle-
dc.identifier.doi10.3389/fimmu.2022.1007382-
dc.identifier.pmid36341431-
dc.identifier.scopuseid_2-s2.0-85141133098-
dc.identifier.volume13-
dc.identifier.eissn1664-3224-
dc.identifier.isiWOS:000880015800001-
dc.identifier.issnl1664-3224-

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