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Article: Maternal periodontal diseases affect the leukocyte profiles of umbilical cord blood: A cohort study

TitleMaternal periodontal diseases affect the leukocyte profiles of umbilical cord blood: A cohort study
Authors
Keywordscomplete blood count
leukocyte profiles
maternal periodontal diseases
maternal peripheral blood
neonates
umbilical cord blood
Issue Date7-Jul-2023
PublisherWiley
Citation
Oral Diseases, 2023 How to Cite?
Abstract

Abstract

Aim

This study evaluated the connection of periodontal status with the leukocyte profiles of maternal peripheral blood (MPB) and umbilical cord blood (UCB).

Materials and Methods

Ninety-nine pregnant females were recruited, and their data were collected via questionnaire and from medical records, including demographics, systemic conditions, complete blood count (CBC) and C-reaction protein (CRP) level in MPB. Full-mouth periodontal assessment was performed. CBC and CRP levels in UCB were measured after parturition.

Results

All subjects and their neonates were generally healthy. 30.3% of the participants presented with periodontal health condition, whereas 69.7% had different severities of periodontal diseases. The counts/percentages of eosinophils and monocytes in UCB from the subjects with periodontal diseases elevated, and the percentage of neutrophils decreased referencing to that from the counterparts (p < 0.05). There were positive correlations for total leukocyte count, neutrophils and lymphocytes counts/percentages in MPB and UCB among the periodontally healthy subjects (r > 0.4, p < 0.05), but such findings did not exist in those with periodontal diseases. Moreover, periodontal diseases independently accounted for the counts/percentages of neutrophils and eosinophils in UCB after controlling confounders in four testing models (ANCOVA, p < 0.05).

Conclusion

Maternal periodontal diseases could to some extent disturb the leukocyte profiles of umbilical cord blood.


Persistent Identifierhttp://hdl.handle.net/10722/331323
ISSN
2023 Impact Factor: 2.9
2023 SCImago Journal Rankings: 0.895
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhao, D-
dc.contributor.authorCheng, TF-
dc.contributor.authorHu, DL-
dc.contributor.authorXu, XY-
dc.contributor.authorZhang, F-
dc.contributor.authorYu, R-
dc.contributor.authorLi, HJ-
dc.contributor.authorWen, P-
dc.contributor.authorChen, LH-
dc.contributor.authorFu, ML-
dc.contributor.authorYang, H-
dc.contributor.authorZhang, HY-
dc.contributor.authorYao, JL-
dc.contributor.authorJin, LJ-
dc.date.accessioned2023-09-21T06:54:43Z-
dc.date.available2023-09-21T06:54:43Z-
dc.date.issued2023-07-07-
dc.identifier.citationOral Diseases, 2023-
dc.identifier.issn1354-523X-
dc.identifier.urihttp://hdl.handle.net/10722/331323-
dc.description.abstract<h2>Abstract</h2><h3>Aim</h3><p>This study evaluated the connection of periodontal status with the leukocyte profiles of maternal peripheral blood (MPB) and umbilical cord blood (UCB).</p><h3>Materials and Methods</h3><p>Ninety-nine pregnant females were recruited, and their data were collected via questionnaire and from medical records, including demographics, systemic conditions, complete blood count (CBC) and C-reaction protein (CRP) level in MPB. Full-mouth periodontal assessment was performed. CBC and CRP levels in UCB were measured after parturition.</p><h3>Results</h3><p>All subjects and their neonates were generally healthy. 30.3% of the participants presented with periodontal health condition, whereas 69.7% had different severities of periodontal diseases. The counts/percentages of eosinophils and monocytes in UCB from the subjects with periodontal diseases elevated, and the percentage of neutrophils decreased referencing to that from the counterparts (<em>p</em> < 0.05). There were positive correlations for total leukocyte count, neutrophils and lymphocytes counts/percentages in MPB and UCB among the periodontally healthy subjects (<em>r</em> > 0.4, <em>p</em> < 0.05), but such findings did not exist in those with periodontal diseases. Moreover, periodontal diseases independently accounted for the counts/percentages of neutrophils and eosinophils in UCB after controlling confounders in four testing models (ANCOVA, <em>p</em> < 0.05).</p><h3>Conclusion</h3><p>Maternal periodontal diseases could to some extent disturb the leukocyte profiles of umbilical cord blood.</p>-
dc.languageeng-
dc.publisherWiley-
dc.relation.ispartofOral Diseases-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectcomplete blood count-
dc.subjectleukocyte profiles-
dc.subjectmaternal periodontal diseases-
dc.subjectmaternal peripheral blood-
dc.subjectneonates-
dc.subjectumbilical cord blood-
dc.titleMaternal periodontal diseases affect the leukocyte profiles of umbilical cord blood: A cohort study-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1111/odi.14683-
dc.identifier.scopuseid_2-s2.0-85165458712-
dc.identifier.eissn1601-0825-
dc.identifier.isiWOS:001034670000001-
dc.identifier.issnl1354-523X-

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