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- Publisher Website: 10.1089/cell.2022.0047
- Scopus: eid_2-s2.0-85144584392
- WOS: WOS:000877069900001
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Article: The Tumor Microenvironment Reprograms Immune Cells
Title | The Tumor Microenvironment Reprograms Immune Cells |
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Authors | |
Keywords | immune cell reprogramming metabolism microenvironment tumor |
Issue Date | 1-Dec-2022 |
Publisher | Mary Ann Liebert |
Citation | Cellular Reprogramming, 2022, v. 24, n. 6, p. 343-352 How to Cite? |
Abstract | Tumor tissue comprises a highly complex network of diverse cell types. The tumor microenvironment (TME) can be mainly subdivided into cancer cells and stromal cell compartments, the latter include different types of immune cells, fibroblasts, endothelial cells, and pericytes. Tumor cells reprogram immune cells and other stromal cells in the TME to constrain their antitumor capacity by creating an immunosuppressive milieu and metabolism competition. Moreover, the reprogramming effect on immune cells is localized not only in the tumor but also at the systemic level. With wide application of single-cell sequencing technology, tumor-specific characteristics of immune cells and other stromal cells in the TME have been dissected. In this review, we mainly focus on how tumor cells reprogram immune cells both within the TME and peripheral blood. This information can further help us to improve the efficiency of current immunotherapy as well as bring up new ideas to combat cancer. |
Persistent Identifier | http://hdl.handle.net/10722/331446 |
ISSN | 2023 Impact Factor: 1.2 2023 SCImago Journal Rankings: 0.316 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Cao, Handi | - |
dc.contributor.author | Gao, Sanxing | - |
dc.contributor.author | Jogani, Ritika | - |
dc.contributor.author | Sugimura, Ryohichi | - |
dc.date.accessioned | 2023-09-21T06:55:49Z | - |
dc.date.available | 2023-09-21T06:55:49Z | - |
dc.date.issued | 2022-12-01 | - |
dc.identifier.citation | Cellular Reprogramming, 2022, v. 24, n. 6, p. 343-352 | - |
dc.identifier.issn | 2152-4971 | - |
dc.identifier.uri | http://hdl.handle.net/10722/331446 | - |
dc.description.abstract | <p>Tumor tissue comprises a highly complex network of diverse cell types. The tumor microenvironment (TME) can be mainly subdivided into cancer cells and stromal cell compartments, the latter include different types of immune cells, fibroblasts, endothelial cells, and pericytes. Tumor cells reprogram immune cells and other stromal cells in the TME to constrain their antitumor capacity by creating an immunosuppressive milieu and metabolism competition. Moreover, the reprogramming effect on immune cells is localized not only in the tumor but also at the systemic level. With wide application of single-cell sequencing technology, tumor-specific characteristics of immune cells and other stromal cells in the TME have been dissected. In this review, we mainly focus on how tumor cells reprogram immune cells both within the TME and peripheral blood. This information can further help us to improve the efficiency of current immunotherapy as well as bring up new ideas to combat cancer.<br></p> | - |
dc.language | eng | - |
dc.publisher | Mary Ann Liebert | - |
dc.relation.ispartof | Cellular Reprogramming | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | immune cell reprogramming | - |
dc.subject | metabolism | - |
dc.subject | microenvironment | - |
dc.subject | tumor | - |
dc.title | The Tumor Microenvironment Reprograms Immune Cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1089/cell.2022.0047 | - |
dc.identifier.scopus | eid_2-s2.0-85144584392 | - |
dc.identifier.volume | 24 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 343 | - |
dc.identifier.epage | 352 | - |
dc.identifier.eissn | 2152-4998 | - |
dc.identifier.isi | WOS:000877069900001 | - |
dc.identifier.issnl | 2152-4971 | - |