File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1002/cdt3.77
- Scopus: eid_2-s2.0-85161823764
- Find via
Supplementary
-
Citations:
- Scopus: 0
- Appears in Collections:
Article: Direct cellular reprogramming and transdifferentiation of fibroblasts on wound healing—Fantasy or reality?
Title | Direct cellular reprogramming and transdifferentiation of fibroblasts on wound healing—Fantasy or reality? |
---|---|
Authors | |
Keywords | direct cellular reprogramming fibroblast wound healing |
Issue Date | 15-Jun-2023 |
Publisher | Wiley Open Access |
Citation | Chronic Diseases and Translational Medicine, 2023, v. 9, n. 3, p. 1-9 How to Cite? |
Abstract | Induced pluripotent stem cell (iPSC) technology is one of the de novo approaches in regeneration medicine and has led to new research applications for wound healing in recent years. Fibroblasts have attracted wide attention as the first cell line used for differentiation into iPSCs. Researchers have found that fibroblasts can be induced into different types of cells in variable mediums or microenvironments. This indicates the potential “stem” characteristics of fibroblasts in terms of direct cellular reprogramming compared with the iPSC detour. In this review, we described the morphology and biological function of fibroblasts. The stem cell characteristics and activities of fibroblasts, including transdifferentiation into myofibroblasts, osteogenic cells, chondrogenic cells, neurons, and vascular tissue, are discussed. The biological values of fibroblasts are then briefly reviewed. Finally, we discussed the potential applications of fibroblasts in clinical practice. |
Persistent Identifier | http://hdl.handle.net/10722/331448 |
ISSN | 2023 SCImago Journal Rankings: 0.764 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Du, Juan | - |
dc.contributor.author | Liu, Xuelai | - |
dc.contributor.author | Wong, Carol Wing Yan | - |
dc.contributor.author | Wong, Kenneth Kak Yuen | - |
dc.contributor.author | Yuan, Zhixin | - |
dc.date.accessioned | 2023-09-21T06:55:50Z | - |
dc.date.available | 2023-09-21T06:55:50Z | - |
dc.date.issued | 2023-06-15 | - |
dc.identifier.citation | Chronic Diseases and Translational Medicine, 2023, v. 9, n. 3, p. 1-9 | - |
dc.identifier.issn | 2095-882X | - |
dc.identifier.uri | http://hdl.handle.net/10722/331448 | - |
dc.description.abstract | <p>Induced pluripotent stem cell (iPSC) technology is one of the de novo approaches in regeneration medicine and has led to new research applications for wound healing in recent years. Fibroblasts have attracted wide attention as the first cell line used for differentiation into iPSCs. Researchers have found that fibroblasts can be induced into different types of cells in variable mediums or microenvironments. This indicates the potential “stem” characteristics of fibroblasts in terms of direct cellular reprogramming compared with the iPSC detour. In this review, we described the morphology and biological function of fibroblasts. The stem cell characteristics and activities of fibroblasts, including transdifferentiation into myofibroblasts, osteogenic cells, chondrogenic cells, neurons, and vascular tissue, are discussed. The biological values of fibroblasts are then briefly reviewed. Finally, we discussed the potential applications of fibroblasts in clinical practice.</p> | - |
dc.language | eng | - |
dc.publisher | Wiley Open Access | - |
dc.relation.ispartof | Chronic Diseases and Translational Medicine | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | direct cellular reprogramming | - |
dc.subject | fibroblast | - |
dc.subject | wound healing | - |
dc.title | Direct cellular reprogramming and transdifferentiation of fibroblasts on wound healing—Fantasy or reality? | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/cdt3.77 | - |
dc.identifier.scopus | eid_2-s2.0-85161823764 | - |
dc.identifier.volume | 9 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 1 | - |
dc.identifier.epage | 9 | - |
dc.identifier.eissn | 2589-0514 | - |
dc.identifier.issnl | 2095-882X | - |