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Article: Detection of Coronaviruses in Bats in Lebanon during 2020

TitleDetection of Coronaviruses in Bats in Lebanon during 2020
Authors
Keywordsbat
coronaviruses
Lebanon
reservoir
SARS-CoV-2
zoonoses
Issue Date26-Jun-2023
PublisherMDPI
Citation
Pathogens, 2023, v. 12, n. 7 How to Cite?
Abstract

Bats are considered the main reservoir of coronaviruses (CoVs), and research evidence suggests the essential role of bats in the emergence of Severe Acute Respiratory Syndrome Coronaviruses (SARS-CoV) and SARS-CoV-2. SARS-CoV-like viruses have been recently detected in bats in different countries. In 2020, we conducted surveillance for CoVs among six different bat species in Lebanon. Of 622 swab specimens taken, 77 tested positive. Alpha- and Beta- CoVs were identified in samples collected from different species. Our results show that SARS-like coronaviruses circulate in bats in this region, and we provide new data on their genetic diversity. The interaction between the spike of the detected SARS-CoV-like viruses and the human angiotensin-converting enzyme 2 (hACE2) receptor could be crucial in understanding the origin of the epidemic. The 3D protein structure analysis revealed that the receptor-binding domains of the SARS-like virus identified in Lebanon bind to the hACE2 protein more efficiently than to the spike of the SARS-CoV-2 strain. The spike of the detected SARS-CoV-like viruses does not contain the recognition site of furin at the cleavage site. Thus, our study highlights the variety of bat coronaviruses in Lebanon and suggests the zoonotic potential for other SARS-CoV-like viruses.


Persistent Identifierhttp://hdl.handle.net/10722/331523
ISSN
2023 Impact Factor: 3.3
2023 SCImago Journal Rankings: 0.843
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKandeil, A-
dc.contributor.authorAbi-Said, M-
dc.contributor.authorBadra, R-
dc.contributor.authorEl-Shesheny, R-
dc.contributor.authorAl-Karmalawy, AA-
dc.contributor.authorAlnajjar, R-
dc.contributor.authorKhalid, Z-
dc.contributor.authorKamel, MN-
dc.contributor.authorHabib, WA-
dc.contributor.authorAbdallah, J-
dc.contributor.authorDhanasekaran, V-
dc.contributor.authorWebby, R-
dc.contributor.authorKayali, G-
dc.date.accessioned2023-09-21T06:56:36Z-
dc.date.available2023-09-21T06:56:36Z-
dc.date.issued2023-06-26-
dc.identifier.citationPathogens, 2023, v. 12, n. 7-
dc.identifier.issn2076-0817-
dc.identifier.urihttp://hdl.handle.net/10722/331523-
dc.description.abstract<p></p><p>Bats are considered the main reservoir of coronaviruses (CoVs), and research evidence suggests the essential role of bats in the emergence of Severe Acute Respiratory Syndrome Coronaviruses (SARS-CoV) and SARS-CoV-2. SARS-CoV-like viruses have been recently detected in bats in different countries. In 2020, we conducted surveillance for CoVs among six different bat species in Lebanon. Of 622 swab specimens taken, 77 tested positive. Alpha- and Beta- CoVs were identified in samples collected from different species. Our results show that SARS-like coronaviruses circulate in bats in this region, and we provide new data on their genetic diversity. The interaction between the spike of the detected SARS-CoV-like viruses and the human angiotensin-converting enzyme 2 (hACE2) receptor could be crucial in understanding the origin of the epidemic. The 3D protein structure analysis revealed that the receptor-binding domains of the SARS-like virus identified in Lebanon bind to the hACE2 protein more efficiently than to the spike of the SARS-CoV-2 strain. The spike of the detected SARS-CoV-like viruses does not contain the recognition site of furin at the cleavage site. Thus, our study highlights the variety of bat coronaviruses in Lebanon and suggests the zoonotic potential for other SARS-CoV-like viruses.<br></p>-
dc.languageeng-
dc.publisherMDPI-
dc.relation.ispartofPathogens-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectbat-
dc.subjectcoronaviruses-
dc.subjectLebanon-
dc.subjectreservoir-
dc.subjectSARS-CoV-2-
dc.subjectzoonoses-
dc.titleDetection of Coronaviruses in Bats in Lebanon during 2020-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/pathogens12070876-
dc.identifier.scopuseid_2-s2.0-85166570947-
dc.identifier.volume12-
dc.identifier.issue7-
dc.identifier.eissn2076-0817-
dc.identifier.isiWOS:001036342800001-
dc.identifier.issnl2076-0817-

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