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Article: Survival at older ages: Are greater influenza antibody titers protective?

TitleSurvival at older ages: Are greater influenza antibody titers protective?
Authors
Metcalf, CJEKlein, SLRead, JMRiley, SCummings, DATGuan, YKwok, KOZhu, HCJiang, CQLam, THLessler, J
KeywordsBiomarker
Immunity
Influenza
Sex difference
Survival
Issue Date1-Sep-2023
PublisherElsevier
Citation
Medical Hypotheses, 2023, v. 178 How to Cite?
DOI: http://dx.doi.org/10.1016/j.mehy.2023.111135
Abstract

Antibodies are a core element of the immune system’s defense against infectious diseases. We hypothesize that antibody titres might therefore be an important predictor of survival in older individuals. This is important because biomarkers that robustly measure survival have proved elusive, despite their potential utility in health care settings. We present evidence supporting the hypothesis that influenza antibody titres are associated with overall survival of older individuals, and indicate a role for biological sex in modulating this association. Since antibody titres can be altered by vaccination, these results have important implications for public health policy on influenza control in aging populations.


Persistent Identifierhttp://hdl.handle.net/10722/331549
ISSN
0306-9877
2023 Impact Factor: 2.1
2023 SCImago Journal Rankings: 0.587
ISI Accession Number ID
WOS:001064985800001

 

DC FieldValueLanguage
dc.contributor.authorMetcalf, CJE-
dc.contributor.authorKlein, SL-
dc.contributor.authorRead, JM-
dc.contributor.authorRiley, S-
dc.contributor.authorCummings, DAT-
dc.contributor.authorGuan, Y-
dc.contributor.authorKwok, KO-
dc.contributor.authorZhu, HC-
dc.contributor.authorJiang, CQ-
dc.contributor.authorLam, TH-
dc.contributor.authorLessler, J-
dc.date.accessioned2023-09-21T06:56:50Z-
dc.date.available2023-09-21T06:56:50Z-
dc.date.issued2023-09-01-
dc.identifier.citationMedical Hypotheses, 2023, v. 178-
dc.identifier.issn0306-9877-
dc.identifier.urihttp://hdl.handle.net/10722/331549-
dc.description.abstract<p>Antibodies are a core element of the immune system’s defense against infectious diseases. We hypothesize that antibody titres might therefore be an important predictor of survival in older individuals. This is important because biomarkers that robustly measure survival have proved elusive, despite their potential utility in <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/health-care" title="Learn more about health care from ScienceDirect's AI-generated Topic Pages">health care</a> settings. We present evidence supporting the hypothesis that influenza antibody titres are associated with overall survival of older individuals, and indicate a role for biological sex in modulating this association. Since antibody titres can be altered by vaccination, these results have important implications for <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/public-health-policy" title="Learn more about public health policy from ScienceDirect's AI-generated Topic Pages">public health policy</a> on influenza control in aging populations.</p>-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofMedical Hypotheses-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectBiomarker-
dc.subjectImmunity-
dc.subjectInfluenza-
dc.subjectSex difference-
dc.subjectSurvival-
dc.titleSurvival at older ages: Are greater influenza antibody titers protective?-
dc.typeArticle-
dc.identifier.doi10.1016/j.mehy.2023.111135-
dc.identifier.scopuseid_2-s2.0-85168351827-
dc.identifier.volume178-
dc.identifier.isiWOS:001064985800001-
dc.identifier.issnl0306-9877-

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