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Article: The cGAS-STING pathway: Post-translational modifications and functional implications in diseases

TitleThe cGAS-STING pathway: Post-translational modifications and functional implications in diseases
Authors
KeywordsCGAS
Disease treatment
Post-translational modifications
Signaling pathway
STING
Issue Date14-Sep-2022
PublisherElsevier
Citation
Cytokine & Growth Factor Reviews, 2022, v. 68, p. 69-80 How to Cite?
Abstract

Recent studies have illustrated the functional significance of DNA recognition in the activation of innate immune responses among a variety of diseases. The cyclic GMP-AMP synthase-stimulator of interferon genes (cGASSTING) pathway has been found to be modulated by post-translational modifications and can regulate the immune response via type I IFNs. Accumulating evidence indicates a pivotal role of cGAS-STING signaling, being protective or pathogenic, in the development of diseases. Thus, a comprehensive understanding of the posttranslational modifications of cGAS-STING pathway and their role in disease development will provide insights in predicting individual disease outcomes and developing appropriate therapies. In this review, we will discuss the regulation of the cGAS-STING pathway and its implications in disease pathologies, as well as pharmacologic strategies to target the cGAS-STING pathway for therapeutic intervention.


Persistent Identifierhttp://hdl.handle.net/10722/331729
ISSN
2023 Impact Factor: 9.3
2023 SCImago Journal Rankings: 2.460
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, Jun-
dc.contributor.authorRui, Ke-
dc.contributor.authorPeng, Na-
dc.contributor.authorLuo, Hui-
dc.contributor.authorZhu, Bo-
dc.contributor.authorZuo, Xiaoxia-
dc.contributor.authorLu, Liwei-
dc.contributor.authorChen, Jixiang-
dc.contributor.authorTian, Jie-
dc.date.accessioned2023-09-21T06:58:24Z-
dc.date.available2023-09-21T06:58:24Z-
dc.date.issued2022-09-14-
dc.identifier.citationCytokine & Growth Factor Reviews, 2022, v. 68, p. 69-80-
dc.identifier.issn1359-6101-
dc.identifier.urihttp://hdl.handle.net/10722/331729-
dc.description.abstract<p>Recent studies have illustrated the functional significance of DNA recognition in the activation of innate immune responses among a variety of diseases. The cyclic GMP-AMP synthase-stimulator of interferon genes (cGASSTING) pathway has been found to be modulated by post-translational modifications and can regulate the immune response via type I IFNs. Accumulating evidence indicates a pivotal role of cGAS-STING signaling, being protective or pathogenic, in the development of diseases. Thus, a comprehensive understanding of the posttranslational modifications of cGAS-STING pathway and their role in disease development will provide insights in predicting individual disease outcomes and developing appropriate therapies. In this review, we will discuss the regulation of the cGAS-STING pathway and its implications in disease pathologies, as well as pharmacologic strategies to target the cGAS-STING pathway for therapeutic intervention.<br></p>-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofCytokine & Growth Factor Reviews-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectCGAS-
dc.subjectDisease treatment-
dc.subjectPost-translational modifications-
dc.subjectSignaling pathway-
dc.subjectSTING-
dc.titleThe cGAS-STING pathway: Post-translational modifications and functional implications in diseases-
dc.typeArticle-
dc.identifier.doi10.1016/j.cytogfr.2022.09.003-
dc.identifier.scopuseid_2-s2.0-85138503212-
dc.identifier.volume68-
dc.identifier.spage69-
dc.identifier.epage80-
dc.identifier.eissn1879-0305-
dc.identifier.isiWOS:000899347200006-
dc.identifier.issnl1359-6101-

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