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Article: Unidirectional diphenylalanine nanotubes for dynamically guiding neurite outgrowth

TitleUnidirectional diphenylalanine nanotubes for dynamically guiding neurite outgrowth
Authors
Keywordsdiphenylalanine
hippocampal neuron
neural network
neurite guidance
tissue engineering
Issue Date8-Dec-2022
PublisherIOP Publishing
Citation
Biomedical Materials, 2022, v. 18, n. 1 How to Cite?
Abstract

Neural networks have been cultured in vitro to investigate brain functions and diseases, clinical treatments for brain damage, and device development. However, it remains challenging to form complex neural network structures with desired orientations and connections in vitro. Here, we introduce a dynamic strategy by using diphenylalanine (FF) nanotubes for controlling physical patterns on a substrate to regulate neurite-growth orientation in cultivating neural networks. Parallel FF nanotube patterns guide neurons to develop neurites through the unidirectional FF nanotubes while restricting their polarization direction. Subsequently, the FF nanotubes disassemble and the restriction of neurites disappear, and secondary neurite development of the neural network occurs in other direction. Experiments were conducted that use the hippocampal neurons, and the results demonstrated that the cultured neural networks by using the proposed dynamic approach can form a significant cross-connected structure with substantially more lateral neural connections than static substrates. The proposed dynamic approach for neurite outgrowing enables the construction of oriented innervation and cross-connected neural networks in vitro and may explore the way for the bio-fabrication of highly complex structures in tissue engineering.


Persistent Identifierhttp://hdl.handle.net/10722/331787
ISSN
2023 Impact Factor: 3.9
2023 SCImago Journal Rankings: 0.712
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZu, Lipeng-
dc.contributor.authorShi, Huiyao-
dc.contributor.authorYang, Jia-
dc.contributor.authorZhang, Chuang-
dc.contributor.authorFu, Yuanyuan-
dc.contributor.authorXi, Ning-
dc.contributor.authorLiu, Lianqing-
dc.contributor.authorWang, Wenxue-
dc.date.accessioned2023-09-21T06:58:54Z-
dc.date.available2023-09-21T06:58:54Z-
dc.date.issued2022-12-08-
dc.identifier.citationBiomedical Materials, 2022, v. 18, n. 1-
dc.identifier.issn1748-6041-
dc.identifier.urihttp://hdl.handle.net/10722/331787-
dc.description.abstract<div><p>Neural networks have been cultured <em>in vitro</em> to investigate brain functions and diseases, clinical treatments for brain damage, and device development. However, it remains challenging to form complex neural network structures with desired orientations and connections <em>in vitro</em>. Here, we introduce a dynamic strategy by using diphenylalanine (FF) nanotubes for controlling physical patterns on a substrate to regulate neurite-growth orientation in cultivating neural networks. Parallel FF nanotube patterns guide neurons to develop neurites through the unidirectional FF nanotubes while restricting their polarization direction. Subsequently, the FF nanotubes disassemble and the restriction of neurites disappear, and secondary neurite development of the neural network occurs in other direction. Experiments were conducted that use the hippocampal neurons, and the results demonstrated that the cultured neural networks by using the proposed dynamic approach can form a significant cross-connected structure with substantially more lateral neural connections than static substrates. The proposed dynamic approach for neurite outgrowing enables the construction of oriented innervation and cross-connected neural networks <em>in vitro</em> and may explore the way for the bio-fabrication of highly complex structures in tissue engineering.</p></div>-
dc.languageeng-
dc.publisherIOP Publishing-
dc.relation.ispartofBiomedical Materials-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectdiphenylalanine-
dc.subjecthippocampal neuron-
dc.subjectneural network-
dc.subjectneurite guidance-
dc.subjecttissue engineering-
dc.titleUnidirectional diphenylalanine nanotubes for dynamically guiding neurite outgrowth-
dc.typeArticle-
dc.identifier.doi10.1088/1748-605X/aca737-
dc.identifier.scopuseid_2-s2.0-85144261759-
dc.identifier.volume18-
dc.identifier.issue1-
dc.identifier.eissn1748-605X-
dc.identifier.isiWOS:000894616200001-
dc.identifier.issnl1748-6041-

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