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Article: A Clinicopathological Study of Young-onset Hepatocellular Carcinoma

TitleA Clinicopathological Study of Young-onset Hepatocellular Carcinoma
Authors
KeywordsImmuno - histochemistry
Liver cancer
Mutation
Young-onset
Issue Date1-Jun-2021
PublisherInternational Institute of Anticancer Research
Citation
Anticancer Research, 2021, v. 41, n. 6, p. 2933-2944 How to Cite?
Abstract

Background/Aim: The aim of this study was to describe the clinicopathological features of hepatocellular carcinoma (HCC) diagnosed at 40 years of age or below. Materials and Methods: Expression of CK19, Glypican-3 and /i-catenin was assessed in clinical samples by immunohistochemistry (IHC). IHC expression was correlated with clinicopathological parameters. Hotspot mutations in TP53 gene were analyzed by sequencing. Results: Thirty-six cases were included with a male to female ratio of 3:1. Eighty percent of cases were associated with chronic hepatitis B infection. CK19 and GPC3 were expressed in 61% and 56% of cases, respectively. Only one case demonstrated /i-catenin over-expression. TP53 hotspot mutation was identified in 4 cases. Number of tumor nodules, vascular invasion, and preoperative serum AFP level were associated with prognosis. Conclusion: A higher CK19 expression rate was observed in our young-onset HCC cohort, whereas /i-catenin pathway activation and TP53 gene mutation events were less frequent. Conventional clinicopathological parameters remain predictors of survival.


Persistent Identifierhttp://hdl.handle.net/10722/331812
ISSN
2023 Impact Factor: 1.6
2023 SCImago Journal Rankings: 0.562
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAu, Kwan-Yung-
dc.contributor.authorChan, Kristy Kwan-Shuen-
dc.contributor.authorLo, Regina Cheuk-Lam-
dc.date.accessioned2023-09-21T06:59:08Z-
dc.date.available2023-09-21T06:59:08Z-
dc.date.issued2021-06-01-
dc.identifier.citationAnticancer Research, 2021, v. 41, n. 6, p. 2933-2944-
dc.identifier.issn0250-7005-
dc.identifier.urihttp://hdl.handle.net/10722/331812-
dc.description.abstract<p>Background/Aim: The aim of this study was to describe the clinicopathological features of hepatocellular carcinoma (HCC) diagnosed at 40 years of age or below. Materials and Methods: Expression of CK19, Glypican-3 and /i-catenin was assessed in clinical samples by immunohistochemistry (IHC). IHC expression was correlated with clinicopathological parameters. Hotspot mutations in TP53 gene were analyzed by sequencing. Results: Thirty-six cases were included with a male to female ratio of 3:1. Eighty percent of cases were associated with chronic hepatitis B infection. CK19 and GPC3 were expressed in 61% and 56% of cases, respectively. Only one case demonstrated /i-catenin over-expression. TP53 hotspot mutation was identified in 4 cases. Number of tumor nodules, vascular invasion, and preoperative serum AFP level were associated with prognosis. Conclusion: A higher CK19 expression rate was observed in our young-onset HCC cohort, whereas /i-catenin pathway activation and TP53 gene mutation events were less frequent. Conventional clinicopathological parameters remain predictors of survival.<br></p>-
dc.languageeng-
dc.publisherInternational Institute of Anticancer Research-
dc.relation.ispartofAnticancer Research-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectImmuno - histochemistry-
dc.subjectLiver cancer-
dc.subjectMutation-
dc.subjectYoung-onset-
dc.titleA Clinicopathological Study of Young-onset Hepatocellular Carcinoma-
dc.typeArticle-
dc.identifier.doi10.21873/anticanres.15075-
dc.identifier.scopuseid_2-s2.0-85107689648-
dc.identifier.volume41-
dc.identifier.issue6-
dc.identifier.spage2933-
dc.identifier.epage2944-
dc.identifier.eissn1791-7530-
dc.identifier.isiWOS:000657631800006-
dc.identifier.issnl0250-7005-

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