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Article: Clinical and neuroimaging markers of neurodegeneration in first-degree relatives of patients with REM sleep behavior disorder with and without isolated rapid eye movement sleep without atonia: A case-control clinical and dopamine PET study

TitleClinical and neuroimaging markers of neurodegeneration in first-degree relatives of patients with REM sleep behavior disorder with and without isolated rapid eye movement sleep without atonia: A case-control clinical and dopamine PET study
Authors
Issue Date1-Feb-2023
PublisherElsevier
Citation
Parkinsonism & Related Disorders, 2023, v. 107 How to Cite?
Abstract

Objectives

The current study aimed to examine the neurodegenerative implication of isolated REM sleep without atonia (RSWA) among first-degree relatives of patients with REM sleep behaviour disorder (RBD).

Methods

This cross-sectional case-control study recruited three groups of subjects: First-degree relatives of RBD patients with isolated RSWA (n = 17), first-degree relatives of RBD patients without isolated RSWA (n = 18), and normal controls who did not have any RWSA and family history of RBD (n = 15). Prodromal Parkinson's Disease likelihood ratio by the updated MDS Research Criteria and striatal dopaminergic transmission function of the subjects as assessed by triple-tracer (18F-DOPA, 11C-Raclopride, and 18F-FDG) PET/CT scan were used as proxy markers of neurodegeneration.

Results

In contrary to our hypothesis, the three groups did not differ in their pre- or post-striatal dopaminergic transmission function, and their Prodromal Parkinson's Disease likelihood ratio. However, they differed significantly in their frequency of a having first-degree relatives with Parkinson's disease or dementia of Lewy body (first-degree relativess with RSWA vs first degree relatives without RSWA vs normal controls = 58.8% vs 22.2% vs 0%, p = 0.001).

Conclusion

FDRs of RBD patients with isolated RSWA did not have increased neurodegenerative markers compared to FDRs of RBD patients without isolated RSWA and normal control, despite an paradoxical increase in frequency of Parkinson's disease or dementia of Lewy body among their family compared to FDRs of RBD patients without isolated RSWA. Further longitudinal follow-up study will be needed to ascertain their long-term prognosis.


Persistent Identifierhttp://hdl.handle.net/10722/331986
ISSN
2023 Impact Factor: 3.1
2023 SCImago Journal Rankings: 1.015
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChau, Steven Wai Ho-
dc.contributor.authorLiu, Yaping-
dc.contributor.authorZhang, Jihui-
dc.contributor.authorLeung, Eric-
dc.contributor.authorChen, Sirong-
dc.contributor.authorHo, Chi Lai-
dc.contributor.authorChan, Joey Wing Yan-
dc.contributor.authorTsang, Chi Ching-
dc.contributor.authorLi, Shirley X-
dc.contributor.authorHuang, Bei-
dc.contributor.authorLam, Siu Ping-
dc.contributor.authorMok, Vincent CT-
dc.contributor.authorWing, Yun Kwok-
dc.date.accessioned2023-09-28T05:00:03Z-
dc.date.available2023-09-28T05:00:03Z-
dc.date.issued2023-02-01-
dc.identifier.citationParkinsonism & Related Disorders, 2023, v. 107-
dc.identifier.issn1353-8020-
dc.identifier.urihttp://hdl.handle.net/10722/331986-
dc.description.abstract<h3>Objectives</h3><p>The current study aimed to examine the neurodegenerative implication of isolated REM sleep without atonia (RSWA) among first-degree relatives of patients with REM sleep behaviour disorder (RBD).</p><h3>Methods</h3><p>This cross-sectional case-control study recruited three groups of subjects: First-degree relatives of RBD patients with isolated RSWA (n = 17), first-degree relatives of RBD patients without isolated RSWA (n = 18), and normal controls who did not have any RWSA and family history of RBD (n = 15). Prodromal Parkinson's Disease likelihood ratio by the updated MDS Research Criteria and striatal dopaminergic transmission function of the subjects as assessed by triple-tracer (18F-DOPA, 11C-Raclopride, and 18F-FDG) PET/CT scan were used as proxy markers of neurodegeneration.</p><h3>Results</h3><p>In contrary to our hypothesis, the three groups did not differ in their pre- or post-striatal dopaminergic transmission function, and their Prodromal Parkinson's Disease likelihood ratio. However, they differed significantly in their frequency of a having first-degree relatives with Parkinson's disease or dementia of Lewy body (first-degree relativess with RSWA vs first degree relatives without RSWA vs normal controls = 58.8% vs 22.2% vs 0%, p = 0.001).</p><h3>Conclusion</h3><p>FDRs of RBD patients with isolated RSWA did not have increased neurodegenerative markers compared to FDRs of RBD patients without isolated RSWA and normal control, despite an paradoxical increase in frequency of Parkinson's disease or dementia of Lewy body among their family compared to FDRs of RBD patients without isolated RSWA. Further longitudinal follow-up study will be needed to ascertain their long-term prognosis.</p>-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofParkinsonism & Related Disorders-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleClinical and neuroimaging markers of neurodegeneration in first-degree relatives of patients with REM sleep behavior disorder with and without isolated rapid eye movement sleep without atonia: A case-control clinical and dopamine PET study-
dc.typeArticle-
dc.identifier.doi10.1016/j.parkreldis.2022.105271-
dc.identifier.scopuseid_2-s2.0-85146084731-
dc.identifier.volume107-
dc.identifier.isiWOS:000925138000001-
dc.identifier.issnl1353-8020-

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