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Article: Sex differences in rapid eye movement sleep behavior disorder: A systematic review and meta-analysis

TitleSex differences in rapid eye movement sleep behavior disorder: A systematic review and meta-analysis
Authors
KeywordsNeurodegenerative disease
Polysomnography
Questionnaire
REM sleep behavior disorder
Sex
Issue Date1-Oct-2023
PublisherElsevier
Citation
Sleep Medicine Reviews, 2023, v. 71 How to Cite?
Abstract

Although rapid eye movement (REM) sleep behavior disorder (RBD) has been widely considered as a male-predominant parasomnia, the existing evidence for the sex difference in the risk of RBD in the general population was conflicting. The present study conducted a systematic review to explore the sex differences in the prevalence, comorbidities, clinical characteristics, and phenoconversion of RBD. One hundred thirty-five eligible studies were identified for the systematic review, and 133 were finally included in the meta-analysis. Males in the general population showed a trend for a higher risk of probable/possible RBD (pRBD), especially among the male older adults (aged & GE;60). In the clinical populations, males showed a significantly higher risk of confirmed RBD, but not of pRBD. Among idiopathic RBD (iRBD) patients, males had a significantly earlier age onset of RBD compared with females. Male patients with Parkinson's disease (PD) had a higher risk of comorbid RBD. There was no significant sex difference in the risk of developing neurodegenerative diseases in iRBD patients. Large scale and prospective studies utilizing stringent diagnostic criteria for RBD are recommended to further verify the sex differences in RBD and to investigate the mechanism underlying the sex difference.


Persistent Identifierhttp://hdl.handle.net/10722/331989
ISSN
2023 Impact Factor: 11.2
2023 SCImago Journal Rankings: 3.561
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Xiao-
dc.contributor.authorZong, Qiang-
dc.contributor.authorLiu, Liu-
dc.contributor.authorLiu, Yaping-
dc.contributor.authorShen, Yanjiao-
dc.contributor.authorTang, Xiangdong-
dc.contributor.authorWing, Yun Kwok-
dc.contributor.authorLi, Shirley Xin-
dc.contributor.authorZhou, Junying-
dc.date.accessioned2023-09-28T05:00:05Z-
dc.date.available2023-09-28T05:00:05Z-
dc.date.issued2023-10-01-
dc.identifier.citationSleep Medicine Reviews, 2023, v. 71-
dc.identifier.issn1087-0792-
dc.identifier.urihttp://hdl.handle.net/10722/331989-
dc.description.abstract<p>Although rapid eye movement (REM) sleep behavior disorder (RBD) has been widely considered as a male-predominant parasomnia, the existing evidence for the sex difference in the risk of RBD in the general population was conflicting. The present study conducted a systematic review to explore the sex differences in the prevalence, comorbidities, clinical characteristics, and phenoconversion of RBD. One hundred thirty-five eligible studies were identified for the systematic review, and 133 were finally included in the meta-analysis. Males in the general population showed a trend for a higher risk of probable/possible RBD (pRBD), especially among the male older adults (aged & GE;60). In the clinical populations, males showed a significantly higher risk of confirmed RBD, but not of pRBD. Among idiopathic RBD (iRBD) patients, males had a significantly earlier age onset of RBD compared with females. Male patients with Parkinson's disease (PD) had a higher risk of comorbid RBD. There was no significant sex difference in the risk of developing neurodegenerative diseases in iRBD patients. Large scale and prospective studies utilizing stringent diagnostic criteria for RBD are recommended to further verify the sex differences in RBD and to investigate the mechanism underlying the sex difference.<br></p>-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofSleep Medicine Reviews-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectNeurodegenerative disease-
dc.subjectPolysomnography-
dc.subjectQuestionnaire-
dc.subjectREM sleep behavior disorder-
dc.subjectSex-
dc.titleSex differences in rapid eye movement sleep behavior disorder: A systematic review and meta-analysis-
dc.typeArticle-
dc.identifier.doi10.1016/j.smrv.2023.101810-
dc.identifier.scopuseid_2-s2.0-85164318598-
dc.identifier.volume71-
dc.identifier.eissn1532-2955-
dc.identifier.isiWOS:001034549400001-
dc.identifier.issnl1087-0792-

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