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Article: The differential effects of sleep deprivation on pain perception in individuals with or without chronic pain: A systematic review and meta-analysis

TitleThe differential effects of sleep deprivation on pain perception in individuals with or without chronic pain: A systematic review and meta-analysis
Authors
KeywordsChronic pain
meta-Analysis
Pain perception
Pain sensitization
Sleep deprivation
Issue Date1-Dec-2022
PublisherElsevier
Citation
Sleep Medicine Reviews, 2022, v. 66 How to Cite?
Abstract

Many experimental sleep deprivation (SD) studies were conducted to clarify the causal relationship between sleep and pain. This systematic review and meta-analysis aimed to update the evidence regarding the effects of different experimental SD paradigms on various pain outcomes. Five databases were searched from their inception to June 2022. Separate random-effects models were used to estimate the pooled effect sizes (ES) of different experimental SD paradigms on various pain outcomes. Thirty-one studies involving 699 healthy individuals and 47 individuals with chronic pain were included. For healthy individuals, limited evidence substantiated that total SD significantly reduced pain threshold and tolerance (ES 0.74-0.95), while moderate evidence supported that partial SD significantly increased spontaneous pain intensity (ES 0.30). Very limited to moderate evidence showed that sleep fragmen-tation significantly increased peripheral and central sensitization in healthy individuals (ES 0.42-0.79). Further, there was very limited evidence that total or partial SD significantly aggravated spontaneous pain intensity in people with chronic pain. Our results accentuated that different SD paradigms differ-entially increased subjective pain intensity and worsened peripheral/central pain sensitization in healthy individuals, whereas the corresponding findings in people with chronic pain remain uncertain. Further rigorous studies are warranted to quantify their relationships in clinical populations.


Persistent Identifierhttp://hdl.handle.net/10722/331998
ISSN
2023 Impact Factor: 11.2
2023 SCImago Journal Rankings: 3.561
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChang, Jeremy R-
dc.contributor.authorFu, Siu-Ngor-
dc.contributor.authorLi, Xun-
dc.contributor.authorLi, Shirley X-
dc.contributor.authorWang, Xiaoyue-
dc.contributor.authorZhou, Zhixing-
dc.contributor.authorPinto, Sabina M-
dc.contributor.authorSamartzis, Dino-
dc.contributor.authorKarppinen, Jaro-
dc.contributor.authorWong, Arnold YL-
dc.date.accessioned2023-09-28T05:00:08Z-
dc.date.available2023-09-28T05:00:08Z-
dc.date.issued2022-12-01-
dc.identifier.citationSleep Medicine Reviews, 2022, v. 66-
dc.identifier.issn1087-0792-
dc.identifier.urihttp://hdl.handle.net/10722/331998-
dc.description.abstract<p>Many experimental sleep deprivation (SD) studies were conducted to clarify the causal relationship between sleep and pain. This systematic review and meta-analysis aimed to update the evidence regarding the effects of different experimental SD paradigms on various pain outcomes. Five databases were searched from their inception to June 2022. Separate random-effects models were used to estimate the pooled effect sizes (ES) of different experimental SD paradigms on various pain outcomes. Thirty-one studies involving 699 healthy individuals and 47 individuals with chronic pain were included. For healthy individuals, limited evidence substantiated that total SD significantly reduced pain threshold and tolerance (ES 0.74-0.95), while moderate evidence supported that partial SD significantly increased spontaneous pain intensity (ES 0.30). Very limited to moderate evidence showed that sleep fragmen-tation significantly increased peripheral and central sensitization in healthy individuals (ES 0.42-0.79). Further, there was very limited evidence that total or partial SD significantly aggravated spontaneous pain intensity in people with chronic pain. Our results accentuated that different SD paradigms differ-entially increased subjective pain intensity and worsened peripheral/central pain sensitization in healthy individuals, whereas the corresponding findings in people with chronic pain remain uncertain. Further rigorous studies are warranted to quantify their relationships in clinical populations.<br></p>-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofSleep Medicine Reviews-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectChronic pain-
dc.subjectmeta-Analysis-
dc.subjectPain perception-
dc.subjectPain sensitization-
dc.subjectSleep deprivation-
dc.titleThe differential effects of sleep deprivation on pain perception in individuals with or without chronic pain: A systematic review and meta-analysis-
dc.typeArticle-
dc.identifier.doi10.1016/j.smrv.2022.101695-
dc.identifier.scopuseid_2-s2.0-85141224176-
dc.identifier.volume66-
dc.identifier.eissn1532-2955-
dc.identifier.isiWOS:000882484500003-
dc.identifier.issnl1087-0792-

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