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Article: Advances in 3D bioprinting technology for functional corneal reconstruction and regeneration

TitleAdvances in 3D bioprinting technology for functional corneal reconstruction and regeneration
Authors
Keywords3D bioprinting
cornea
keratoprosthesis
reconstruction
regeneration
Issue Date6-Jan-2023
PublisherFrontiers Media
Citation
Frontiers in Bioengineering and Biotechnology, 2023, v. 10 How to Cite?
Abstract

Corneal transplantation constitutes one of the major treatments in severe cases of corneal diseases. The lack of cornea donors as well as other limitations of corneal transplantation necessitate the development of artificial corneal substitutes. Biosynthetic cornea model using 3D printing technique is promising to generate artificial corneal structure that can resemble the structure of the native human cornea and is applicable for regenerative medicine. Research on bioprinting artificial cornea has raised interest into the wide range of materials and cells that can be utilized as bioinks for optimal clarity, biocompatibility, and tectonic strength. With continued advances in biomaterials science and printing technology, it is believed that bioprinted cornea will eventually achieve a level of clinical functionality and practicality as to replace donated corneal tissues, with their associated limitations such as limited or unsteady supply, and possible infectious disease transmission. Here, we review the literature on bioprinting strategies, 3D corneal modelling, material options, and cellularization strategies in relation to keratoprosthesis design. The progress, limitations and expectations of recent cases of 3D bioprinting of artifial cornea are discussed. An outlook on the rise of 3D bioprinting in corneal reconstruction and regeneration is provided.


Persistent Identifierhttp://hdl.handle.net/10722/332034
ISSN
2023 Impact Factor: 4.3
2023 SCImago Journal Rankings: 0.893
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJia, Shuo-
dc.contributor.authorBu, Yashan-
dc.contributor.authorLau, Dzi-Shing Aaron-
dc.contributor.authorLin, Zhizhen-
dc.contributor.authorSun, Tianhao-
dc.contributor.authorLu, Weijia William-
dc.contributor.authorLu, Sheng-
dc.contributor.authorRuan, Changshun-
dc.contributor.authorChan, Cheuk-Hung Jonathan-
dc.date.accessioned2023-09-28T05:00:24Z-
dc.date.available2023-09-28T05:00:24Z-
dc.date.issued2023-01-06-
dc.identifier.citationFrontiers in Bioengineering and Biotechnology, 2023, v. 10-
dc.identifier.issn2296-4185-
dc.identifier.urihttp://hdl.handle.net/10722/332034-
dc.description.abstract<p></p><p>Corneal transplantation constitutes one of the major treatments in severe cases of corneal diseases. The lack of cornea donors as well as other limitations of corneal transplantation necessitate the development of artificial corneal substitutes. Biosynthetic cornea model using 3D printing technique is promising to generate artificial corneal structure that can resemble the structure of the native human cornea and is applicable for regenerative medicine. Research on bioprinting artificial cornea has raised interest into the wide range of materials and cells that can be utilized as bioinks for optimal clarity, biocompatibility, and tectonic strength. With continued advances in biomaterials science and printing technology, it is believed that bioprinted cornea will eventually achieve a level of clinical functionality and practicality as to replace donated corneal tissues, with their associated limitations such as limited or unsteady supply, and possible infectious disease transmission. Here, we review the literature on bioprinting strategies, 3D corneal modelling, material options, and cellularization strategies in relation to keratoprosthesis design. The progress, limitations and expectations of recent cases of 3D bioprinting of artifial cornea are discussed. An outlook on the rise of 3D bioprinting in corneal reconstruction and regeneration is provided.<br></p>-
dc.languageeng-
dc.publisherFrontiers Media-
dc.relation.ispartofFrontiers in Bioengineering and Biotechnology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subject3D bioprinting-
dc.subjectcornea-
dc.subjectkeratoprosthesis-
dc.subjectreconstruction-
dc.subjectregeneration-
dc.titleAdvances in 3D bioprinting technology for functional corneal reconstruction and regeneration-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3389/fbioe.2022.1065460-
dc.identifier.scopuseid_2-s2.0-85146486933-
dc.identifier.volume10-
dc.identifier.eissn2296-4185-
dc.identifier.isiWOS:000915610700001-
dc.identifier.issnl2296-4185-

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