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- Publisher Website: 10.1021/jo030203g
- Scopus: eid_2-s2.0-0242289316
- PMID: 14575475
- WOS: WOS:000186156700025
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Article: Chemically Defined Sialoside Scaffolds for Investigation of Multivalent Interactions with Sialic Acid Binding Proteins
Title | Chemically Defined Sialoside Scaffolds for Investigation of Multivalent Interactions with Sialic Acid Binding Proteins |
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Authors | |
Issue Date | 2003 |
Citation | Journal of Organic Chemistry, 2003, v. 68, n. 22, p. 8485-8493 How to Cite? |
Abstract | Four glycodendrons and a glycocluster were synthesized from carbohydrate building blocks to form paucivalent (di- to tetravalent) structures of controlled scaffold architectures. Enzymatic sialylation of the functionalized cluster and dendrons, terminated in lactose residues, generated a library of paucivalent synthetic sialosides displaying sialic acids with different dispositions. These newly constructed bioactive sialic acid-based structures were differentially recognized by sialoadhesin, a mammalian macrophage sialic acid binding protein. The binding of the sialosides to sialoadhesin was evaluated by an enzyme-linked immunosorbant assay to investigate the complementarity of scaffold structure and binding to sialoadhesin. Modulating the interaction between sialoadhesin and its sialic acid ligands has important implications in immunobiology. |
Persistent Identifier | http://hdl.handle.net/10722/332547 |
ISSN | 2023 Impact Factor: 3.3 2023 SCImago Journal Rankings: 0.724 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Kalovidouris, Stacey A. | - |
dc.contributor.author | Blixt, Ola | - |
dc.contributor.author | Nelson, Alshakim | - |
dc.contributor.author | Vidal, Sébastien | - |
dc.contributor.author | Turnbull, W. Bruce | - |
dc.contributor.author | Paulson, James C. | - |
dc.contributor.author | Stoddart, J. Fraser | - |
dc.date.accessioned | 2023-10-06T05:12:22Z | - |
dc.date.available | 2023-10-06T05:12:22Z | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | Journal of Organic Chemistry, 2003, v. 68, n. 22, p. 8485-8493 | - |
dc.identifier.issn | 0022-3263 | - |
dc.identifier.uri | http://hdl.handle.net/10722/332547 | - |
dc.description.abstract | Four glycodendrons and a glycocluster were synthesized from carbohydrate building blocks to form paucivalent (di- to tetravalent) structures of controlled scaffold architectures. Enzymatic sialylation of the functionalized cluster and dendrons, terminated in lactose residues, generated a library of paucivalent synthetic sialosides displaying sialic acids with different dispositions. These newly constructed bioactive sialic acid-based structures were differentially recognized by sialoadhesin, a mammalian macrophage sialic acid binding protein. The binding of the sialosides to sialoadhesin was evaluated by an enzyme-linked immunosorbant assay to investigate the complementarity of scaffold structure and binding to sialoadhesin. Modulating the interaction between sialoadhesin and its sialic acid ligands has important implications in immunobiology. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Organic Chemistry | - |
dc.title | Chemically Defined Sialoside Scaffolds for Investigation of Multivalent Interactions with Sialic Acid Binding Proteins | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/jo030203g | - |
dc.identifier.pmid | 14575475 | - |
dc.identifier.scopus | eid_2-s2.0-0242289316 | - |
dc.identifier.volume | 68 | - |
dc.identifier.issue | 22 | - |
dc.identifier.spage | 8485 | - |
dc.identifier.epage | 8493 | - |
dc.identifier.isi | WOS:000186156700025 | - |