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Article: Can Multivalency Be Expressed Kinetically? The Answer Is Yes

TitleCan Multivalency Be Expressed Kinetically? The Answer Is Yes
Authors
Issue Date2004
Citation
Journal of the American Chemical Society, 2004, v. 126, n. 8, p. 2288-2289 How to Cite?
AbstractInspired by the concept of multivalency and in pursuit of ever more intricate artificial molecular machines, we investigated the strict self-assembly of a triply threaded two-component superbundle, starting from a tritopic receptor in which three benzo[24]crown-8 macrorings are fused onto a triphenylene core and a trifurcated trication wherein three bipyridinium units are linked 1,3,5 to a central benzenoid core. The result of the investigation was quite unexpected and surprising. It transpired that the rapid formation of a doubly threaded two-component complex was followed by an extremely slow conversion (a week at 253 K in CD3COCD3 to reach equilibrium) of this kinetically controlled product into a thermodynamically controlled one, namely a triply threaded two-component superbundle. This intriguing observation begs the question: are there instances in nature where multivalency is expressed as a kinetically controlled process, prior to an equilibrium state being reached, and if so, what are the biological implications, if any? Copyright © 2004 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/332586
ISSN
2023 Impact Factor: 14.4
2023 SCImago Journal Rankings: 5.489
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBadjić, Jovica D.-
dc.contributor.authorCantrill, Stuart J.-
dc.contributor.authorStoddart, J. Fraser-
dc.date.accessioned2023-10-06T05:12:40Z-
dc.date.available2023-10-06T05:12:40Z-
dc.date.issued2004-
dc.identifier.citationJournal of the American Chemical Society, 2004, v. 126, n. 8, p. 2288-2289-
dc.identifier.issn0002-7863-
dc.identifier.urihttp://hdl.handle.net/10722/332586-
dc.description.abstractInspired by the concept of multivalency and in pursuit of ever more intricate artificial molecular machines, we investigated the strict self-assembly of a triply threaded two-component superbundle, starting from a tritopic receptor in which three benzo[24]crown-8 macrorings are fused onto a triphenylene core and a trifurcated trication wherein three bipyridinium units are linked 1,3,5 to a central benzenoid core. The result of the investigation was quite unexpected and surprising. It transpired that the rapid formation of a doubly threaded two-component complex was followed by an extremely slow conversion (a week at 253 K in CD3COCD3 to reach equilibrium) of this kinetically controlled product into a thermodynamically controlled one, namely a triply threaded two-component superbundle. This intriguing observation begs the question: are there instances in nature where multivalency is expressed as a kinetically controlled process, prior to an equilibrium state being reached, and if so, what are the biological implications, if any? Copyright © 2004 American Chemical Society.-
dc.languageeng-
dc.relation.ispartofJournal of the American Chemical Society-
dc.titleCan Multivalency Be Expressed Kinetically? The Answer Is Yes-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/ja0395285-
dc.identifier.scopuseid_2-s2.0-1542345324-
dc.identifier.volume126-
dc.identifier.issue8-
dc.identifier.spage2288-
dc.identifier.epage2289-
dc.identifier.isiWOS:000189279700015-

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