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Article: Monitoring cyclodextrin-polyviologen pseudopolyrotaxanes with the Bradford assay

TitleMonitoring cyclodextrin-polyviologen pseudopolyrotaxanes with the Bradford assay
Authors
Issue Date2006
Citation
Organic and Biomolecular Chemistry, 2006, v. 4, n. 2, p. 250-256 How to Cite?
AbstractSelf-assembled multivalent pseudopolyrotaxanes, composed of lactoside-bearing cyclodextrin (CD) rings threaded on linear polyviologen polymers, have been introduced recently as flexible and dynamic neoglycoconjugates. In the course of this research, it was found that polyviologens are responsive to the Bradford assay, which is traditionally highly selective for proteins. The response of the pseudopolyrotaxanes to the Bradford assay was dependant on, and thus indicative of, the degree of threading of the CD rings onto the polyelectrolyte. The assay was then used to report on the threading and dethreading of native and lactoside-bearing α-CD rings onto and off of polyviologen chains, a phenomenon which demonstrates the utility of biochemical assays to address problems unique to supramolecular chemistry. © The Royal Society of Chemistry 2006.
Persistent Identifierhttp://hdl.handle.net/10722/332663
ISSN
2023 Impact Factor: 2.9
2023 SCImago Journal Rankings: 0.607
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBelitsky, Jason M.-
dc.contributor.authorNelson, Alshakim-
dc.contributor.authorStoddart, J. Fraser-
dc.date.accessioned2023-10-06T05:13:19Z-
dc.date.available2023-10-06T05:13:19Z-
dc.date.issued2006-
dc.identifier.citationOrganic and Biomolecular Chemistry, 2006, v. 4, n. 2, p. 250-256-
dc.identifier.issn1477-0520-
dc.identifier.urihttp://hdl.handle.net/10722/332663-
dc.description.abstractSelf-assembled multivalent pseudopolyrotaxanes, composed of lactoside-bearing cyclodextrin (CD) rings threaded on linear polyviologen polymers, have been introduced recently as flexible and dynamic neoglycoconjugates. In the course of this research, it was found that polyviologens are responsive to the Bradford assay, which is traditionally highly selective for proteins. The response of the pseudopolyrotaxanes to the Bradford assay was dependant on, and thus indicative of, the degree of threading of the CD rings onto the polyelectrolyte. The assay was then used to report on the threading and dethreading of native and lactoside-bearing α-CD rings onto and off of polyviologen chains, a phenomenon which demonstrates the utility of biochemical assays to address problems unique to supramolecular chemistry. © The Royal Society of Chemistry 2006.-
dc.languageeng-
dc.relation.ispartofOrganic and Biomolecular Chemistry-
dc.titleMonitoring cyclodextrin-polyviologen pseudopolyrotaxanes with the Bradford assay-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/b509576j-
dc.identifier.pmid16391767-
dc.identifier.scopuseid_2-s2.0-33645679105-
dc.identifier.volume4-
dc.identifier.issue2-
dc.identifier.spage250-
dc.identifier.epage256-
dc.identifier.isiWOS:000234887800021-

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