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Article: Functionally rigid and degenerate molecular shuttles

TitleFunctionally rigid and degenerate molecular shuttles
Authors
KeywordsMolecular modeling
Molecular shuttles
Rotaxanes
Self-assembly
Template-directed synthesis
Issue Date2009
Citation
Chemistry - A European Journal, 2009, v. 15, n. 5, p. 1115-1122 How to Cite?
AbstractThe preparation and dynamic behavior of two functionally rigid and degenerate [2]rotaxanes (1·4PF6 and 2·4PF6) in which a π-electron deficient tetracationic cyclophane, cyclobis(para-quat-p-phenylene) (CBPQT4+) ring, shuttles back and forth between two π-electron-rich naphthalene (NP) stations by making the passage along an ethynyl-phenylene-(PH)-ethynyl or buta-diyne rod, are described. The [2]rotaxanes were synthesized by using the clipping approach to template-directed synthesis, and were characterized by NMR spectroscopic and mass spectrometry analyses. 1H NMR spectra of both [2]rotaxanes show evidence for the formation of mechanically interlocked structures, resulting in the upfield shifts of the resonances for key protons on the dumbbell-shaped components. In particular, the signals for the peri protons on the NP units in the dumbbell-shaped components experienced significant upfield shifts at low temperatures, just as has been observed in the flexible [2]rotaxanes. Interestingly, the resonances for the same protons did not exhibit a significant upfield shift at 298 K, but rather only a modest shift. This phenomenon arises from the much reduced binding of the ethynylNP unit compared to the 1,5-dioxy-NP unit. This effect, in turn, increases the shuttling rate when compared to the 1,5-dioxy-NP-based rotaxane systems investigated previously. The kinetic and thermodynamic data of the shuttling behavior of the CBPQT4+ ring between the NP units were obtained by variable-temperature NMR spectroscopy and using the coalescence method to calculate the free energies of activation (δGc=) of 9.6 and 10.3 kcal mor-1 for 1·4PF6 and 2·4PF6, respectively, probed by using the rotaxane's α-bipyridinium protons. The solid-state structure of the free dumbbell-shaped compound (3) shows the fully rigid ethynyl-PH-ethynyl linker with a length (8.1 Å) twice as long as that (3.8 Å) of the butadiyne linker. Full-atomistic simulations were carried out with the DREIDING force field (FF) to probe the degenerate molecular shuttling processes, and afforded shuttling energy barriers (ΔG≠ = 10.4 kcal mol -1 for 1·4PF6 and 2·4PF6) that are in good agreement with the experimental values (ΔGc≠ = 9.6 and 10.3 kcal mor-1 for 1·4PF 6 and 2·4PF6, respectively, probed by using their α-bipyridinium protons). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
Persistent Identifierhttp://hdl.handle.net/10722/332868
ISSN
2023 Impact Factor: 3.9
2023 SCImago Journal Rankings: 1.058
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYoon, Il-
dc.contributor.authorBenítez, Diego-
dc.contributor.authorZhao, Yan Li-
dc.contributor.authorMiljanić, Ognjen Š-
dc.contributor.authorKim, Soo Young-
dc.contributor.authorTkatchouk, Ekaterina-
dc.contributor.authorLeung, Ken C.F.-
dc.contributor.authorKhan, Saeed I.-
dc.contributor.authorGoddard, William A.-
dc.contributor.authorStoddart, J. Fraser-
dc.date.accessioned2023-10-06T05:14:53Z-
dc.date.available2023-10-06T05:14:53Z-
dc.date.issued2009-
dc.identifier.citationChemistry - A European Journal, 2009, v. 15, n. 5, p. 1115-1122-
dc.identifier.issn0947-6539-
dc.identifier.urihttp://hdl.handle.net/10722/332868-
dc.description.abstractThe preparation and dynamic behavior of two functionally rigid and degenerate [2]rotaxanes (1·4PF6 and 2·4PF6) in which a π-electron deficient tetracationic cyclophane, cyclobis(para-quat-p-phenylene) (CBPQT4+) ring, shuttles back and forth between two π-electron-rich naphthalene (NP) stations by making the passage along an ethynyl-phenylene-(PH)-ethynyl or buta-diyne rod, are described. The [2]rotaxanes were synthesized by using the clipping approach to template-directed synthesis, and were characterized by NMR spectroscopic and mass spectrometry analyses. 1H NMR spectra of both [2]rotaxanes show evidence for the formation of mechanically interlocked structures, resulting in the upfield shifts of the resonances for key protons on the dumbbell-shaped components. In particular, the signals for the peri protons on the NP units in the dumbbell-shaped components experienced significant upfield shifts at low temperatures, just as has been observed in the flexible [2]rotaxanes. Interestingly, the resonances for the same protons did not exhibit a significant upfield shift at 298 K, but rather only a modest shift. This phenomenon arises from the much reduced binding of the ethynylNP unit compared to the 1,5-dioxy-NP unit. This effect, in turn, increases the shuttling rate when compared to the 1,5-dioxy-NP-based rotaxane systems investigated previously. The kinetic and thermodynamic data of the shuttling behavior of the CBPQT4+ ring between the NP units were obtained by variable-temperature NMR spectroscopy and using the coalescence method to calculate the free energies of activation (δGc=) of 9.6 and 10.3 kcal mor-1 for 1·4PF6 and 2·4PF6, respectively, probed by using the rotaxane's α-bipyridinium protons. The solid-state structure of the free dumbbell-shaped compound (3) shows the fully rigid ethynyl-PH-ethynyl linker with a length (8.1 Å) twice as long as that (3.8 Å) of the butadiyne linker. Full-atomistic simulations were carried out with the DREIDING force field (FF) to probe the degenerate molecular shuttling processes, and afforded shuttling energy barriers (ΔG≠ = 10.4 kcal mol -1 for 1·4PF6 and 2·4PF6) that are in good agreement with the experimental values (ΔGc≠ = 9.6 and 10.3 kcal mor-1 for 1·4PF 6 and 2·4PF6, respectively, probed by using their α-bipyridinium protons). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.-
dc.languageeng-
dc.relation.ispartofChemistry - A European Journal-
dc.subjectMolecular modeling-
dc.subjectMolecular shuttles-
dc.subjectRotaxanes-
dc.subjectSelf-assembly-
dc.subjectTemplate-directed synthesis-
dc.titleFunctionally rigid and degenerate molecular shuttles-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/chem.200802096-
dc.identifier.scopuseid_2-s2.0-58449128736-
dc.identifier.volume15-
dc.identifier.issue5-
dc.identifier.spage1115-
dc.identifier.epage1122-
dc.identifier.eissn1521-3765-
dc.identifier.isiWOS:000263093700009-

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