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Article: Synthetic oligorotaxanes exert high forces when folding under mechanical load

TitleSynthetic oligorotaxanes exert high forces when folding under mechanical load
Authors
Issue Date2018
Citation
Nature Nanotechnology, 2018, v. 13, n. 3, p. 209-213 How to Cite?
AbstractFolding is a ubiquitous process that nature uses to control the conformations of its molecular machines, allowing them to perform chemical and mechanical tasks. Over the years, chemists have synthesized foldamers that adopt well-defined and stable folded architectures, mimicking the control expressed by natural systems 1,2 . Mechanically interlocked molecules, such as rotaxanes and catenanes, are prototypical molecular machines that enable the controlled movement and positioning of their component parts 3-5 . Recently, combining the exquisite complexity of these two classes of molecules, donor-acceptor oligorotaxane foldamers have been synthesized, in which interactions between the mechanically interlocked component parts dictate the single-molecule assembly into a folded secondary structure 6-8 . Here we report on the mechanochemical properties of these molecules. We use atomic force microscopy-based single-molecule force spectroscopy to mechanically unfold oligorotaxanes, made of oligomeric dumbbells incorporating 1,5-dioxynaphthalene units encircled by cyclobis(paraquat-p-phenylene) rings. Real-time capture of fluctuations between unfolded and folded states reveals that the molecules exert forces of up to 50 pN against a mechanical load of up to 150 pN, and displays transition times of less than 10 μs. While the folding is at least as fast as that observed in proteins, it is remarkably more robust, thanks to the mechanically interlocked structure. Our results show that synthetic oligorotaxanes have the potential to exceed the performance of natural folding proteins.
Persistent Identifierhttp://hdl.handle.net/10722/333309
ISSN
2023 Impact Factor: 38.1
2023 SCImago Journal Rankings: 14.577
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSluysmans, Damien-
dc.contributor.authorHubert, Sandrine-
dc.contributor.authorBruns, Carson J.-
dc.contributor.authorZhu, Zhixue-
dc.contributor.authorStoddart, J. Fraser-
dc.contributor.authorDuwez, Anne Sophie-
dc.date.accessioned2023-10-06T05:18:22Z-
dc.date.available2023-10-06T05:18:22Z-
dc.date.issued2018-
dc.identifier.citationNature Nanotechnology, 2018, v. 13, n. 3, p. 209-213-
dc.identifier.issn1748-3387-
dc.identifier.urihttp://hdl.handle.net/10722/333309-
dc.description.abstractFolding is a ubiquitous process that nature uses to control the conformations of its molecular machines, allowing them to perform chemical and mechanical tasks. Over the years, chemists have synthesized foldamers that adopt well-defined and stable folded architectures, mimicking the control expressed by natural systems 1,2 . Mechanically interlocked molecules, such as rotaxanes and catenanes, are prototypical molecular machines that enable the controlled movement and positioning of their component parts 3-5 . Recently, combining the exquisite complexity of these two classes of molecules, donor-acceptor oligorotaxane foldamers have been synthesized, in which interactions between the mechanically interlocked component parts dictate the single-molecule assembly into a folded secondary structure 6-8 . Here we report on the mechanochemical properties of these molecules. We use atomic force microscopy-based single-molecule force spectroscopy to mechanically unfold oligorotaxanes, made of oligomeric dumbbells incorporating 1,5-dioxynaphthalene units encircled by cyclobis(paraquat-p-phenylene) rings. Real-time capture of fluctuations between unfolded and folded states reveals that the molecules exert forces of up to 50 pN against a mechanical load of up to 150 pN, and displays transition times of less than 10 μs. While the folding is at least as fast as that observed in proteins, it is remarkably more robust, thanks to the mechanically interlocked structure. Our results show that synthetic oligorotaxanes have the potential to exceed the performance of natural folding proteins.-
dc.languageeng-
dc.relation.ispartofNature Nanotechnology-
dc.titleSynthetic oligorotaxanes exert high forces when folding under mechanical load-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/s41565-017-0033-7-
dc.identifier.pmid29292379-
dc.identifier.scopuseid_2-s2.0-85039787241-
dc.identifier.volume13-
dc.identifier.issue3-
dc.identifier.spage209-
dc.identifier.epage213-
dc.identifier.eissn1748-3395-
dc.identifier.isiWOS:000427009000013-

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