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Article: Artificial Allomelanin Nanoparticles

TitleArtificial Allomelanin Nanoparticles
Authors
Zhou, XuhaoMcCallum, Naneki C.Hu, ZiyingCao, WeiGnanasekaran, KarthikeyanFeng, YuanningStoddart, J. FraserWang, ZhaoGianneschi, Nathan C.
Keywordsallomelanin
DHN melanin
radiation protection
radical scavenging activity
synthetic melanin
Issue Date2019
Citation
ACS Nano, 2019, v. 13, n. 10, p. 10980-10990 How to Cite?
DOI: http://dx.doi.org/10.1021/acsnano.9b02160
AbstractAllomelanin is a type of nitrogen-free melanin most commonly found in fungi. Its existence enhances resistance of the organisms to environmental damage and helps fungi survive harsh radiation conditions such as those found on spacecraft and inside contaminated nuclear power plants. We report the preparation and characterization of artificial allomelanin nanoparticles (AMNPs) via oxidative oligomerization of 1,8-dihydroxynaphthalene (1,8-DHN). We describe the resulting morphological and size control of AMNPs and demonstrate that they are radical scavengers. Finally, we show that AMNPs are taken up by neonatal human epidermal keratinocytes and packaged into perinuclear caps where they quench reactive oxygen species generated following UV exposure.
Persistent Identifierhttp://hdl.handle.net/10722/333391
ISSN
1936-0851
2021 Impact Factor: 18.027
2020 SCImago Journal Rankings: 5.554
ISI Accession Number ID
WOS:000492801600012

 

DC FieldValueLanguage
dc.contributor.authorZhou, Xuhao-
dc.contributor.authorMcCallum, Naneki C.-
dc.contributor.authorHu, Ziying-
dc.contributor.authorCao, Wei-
dc.contributor.authorGnanasekaran, Karthikeyan-
dc.contributor.authorFeng, Yuanning-
dc.contributor.authorStoddart, J. Fraser-
dc.contributor.authorWang, Zhao-
dc.contributor.authorGianneschi, Nathan C.-
dc.date.accessioned2023-10-06T05:19:00Z-
dc.date.available2023-10-06T05:19:00Z-
dc.date.issued2019-
dc.identifier.citationACS Nano, 2019, v. 13, n. 10, p. 10980-10990-
dc.identifier.issn1936-0851-
dc.identifier.urihttp://hdl.handle.net/10722/333391-
dc.description.abstractAllomelanin is a type of nitrogen-free melanin most commonly found in fungi. Its existence enhances resistance of the organisms to environmental damage and helps fungi survive harsh radiation conditions such as those found on spacecraft and inside contaminated nuclear power plants. We report the preparation and characterization of artificial allomelanin nanoparticles (AMNPs) via oxidative oligomerization of 1,8-dihydroxynaphthalene (1,8-DHN). We describe the resulting morphological and size control of AMNPs and demonstrate that they are radical scavengers. Finally, we show that AMNPs are taken up by neonatal human epidermal keratinocytes and packaged into perinuclear caps where they quench reactive oxygen species generated following UV exposure.-
dc.languageeng-
dc.relation.ispartofACS Nano-
dc.subjectallomelanin-
dc.subjectDHN melanin-
dc.subjectradiation protection-
dc.subjectradical scavenging activity-
dc.subjectsynthetic melanin-
dc.titleArtificial Allomelanin Nanoparticles-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acsnano.9b02160-
dc.identifier.pmid31524373-
dc.identifier.scopuseid_2-s2.0-85072827770-
dc.identifier.volume13-
dc.identifier.issue10-
dc.identifier.spage10980-
dc.identifier.epage10990-
dc.identifier.eissn1936-086X-
dc.identifier.isiWOS:000492801600012-

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