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Article: Radical-Enriched Artificial Melanin

TitleRadical-Enriched Artificial Melanin
Authors
Issue Date2020
Citation
Chemistry of Materials, 2020, v. 32, n. 13, p. 5759-5767 How to Cite?
AbstractMelanin is a class of ubiquitous, heterogeneous, polymeric pigments. One of the most unusual features of melanin is the presence of stable persistent radicals, which has been reported to relate to ionizing radiation protection, including X-rays and gamma rays. In this work, we aimed to increase the radical content by introducing nitroxide radicals into synthetic melanin nanomaterials. Nanoparticles (NPs) were prepared by copolymerization of a stable radical modified monomer with the monomer dopamine. The radical content increased to 1 order of magnitude higher than that of the conventional melanin-like material, polydopamine. These radical NPs can enter human epidermal keratinocytes and form perinuclear caps, mimicking natural melanin synthesized by melanocytes. We demonstrated that these NPs display protective properties by scavenging reactive oxygen species, one of the most important biological effects of ionizing radiation exposure. This finding may have potential application for materials capable of mitigating side effects of clinical radiation therapy.
Persistent Identifierhttp://hdl.handle.net/10722/333450
ISSN
2023 Impact Factor: 7.2
2023 SCImago Journal Rankings: 2.421
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCao, Wei-
dc.contributor.authorMantanona, Alex J.-
dc.contributor.authorMao, Haochuan-
dc.contributor.authorMcCallum, Naneki C.-
dc.contributor.authorJiao, Yang-
dc.contributor.authorBattistella, Claudia-
dc.contributor.authorCaponetti, Valeria-
dc.contributor.authorZang, Nanzhi-
dc.contributor.authorThompson, Matthew P.-
dc.contributor.authorMontalti, Marco-
dc.contributor.authorStoddart, J. Fraser-
dc.contributor.authorWasielewski, Michael R.-
dc.contributor.authorRinehart, Jeffrey D.-
dc.contributor.authorGianneschi, Nathan C.-
dc.date.accessioned2023-10-06T05:19:28Z-
dc.date.available2023-10-06T05:19:28Z-
dc.date.issued2020-
dc.identifier.citationChemistry of Materials, 2020, v. 32, n. 13, p. 5759-5767-
dc.identifier.issn0897-4756-
dc.identifier.urihttp://hdl.handle.net/10722/333450-
dc.description.abstractMelanin is a class of ubiquitous, heterogeneous, polymeric pigments. One of the most unusual features of melanin is the presence of stable persistent radicals, which has been reported to relate to ionizing radiation protection, including X-rays and gamma rays. In this work, we aimed to increase the radical content by introducing nitroxide radicals into synthetic melanin nanomaterials. Nanoparticles (NPs) were prepared by copolymerization of a stable radical modified monomer with the monomer dopamine. The radical content increased to 1 order of magnitude higher than that of the conventional melanin-like material, polydopamine. These radical NPs can enter human epidermal keratinocytes and form perinuclear caps, mimicking natural melanin synthesized by melanocytes. We demonstrated that these NPs display protective properties by scavenging reactive oxygen species, one of the most important biological effects of ionizing radiation exposure. This finding may have potential application for materials capable of mitigating side effects of clinical radiation therapy.-
dc.languageeng-
dc.relation.ispartofChemistry of Materials-
dc.titleRadical-Enriched Artificial Melanin-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acs.chemmater.0c01573-
dc.identifier.scopuseid_2-s2.0-85088099974-
dc.identifier.volume32-
dc.identifier.issue13-
dc.identifier.spage5759-
dc.identifier.epage5767-
dc.identifier.eissn1520-5002-
dc.identifier.isiWOS:000551412800036-

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