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- Publisher Website: 10.1021/ja1022267
- Scopus: eid_2-s2.0-77955382309
- PMID: 20681678
- WOS: WOS:000280692200003
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Article: Noninvasive remote-controlled release of drug molecules in vitro using magnetic actuation of mechanized nanoparticles
Title | Noninvasive remote-controlled release of drug molecules in vitro using magnetic actuation of mechanized nanoparticles |
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Authors | |
Issue Date | 2010 |
Citation | Journal of the American Chemical Society, 2010, v. 132, n. 31, p. 10623-10625 How to Cite? |
Abstract | Mesoporous silica nanoparticles are useful nanomaterials that have demonstrated the ability to contain and release cargos with mediation by gatekeepers. Magnetic nanocrystals have the ability to exhibit hyperthermic effects when placed in an oscillating magnetic field. In a system combining these two materials and a thermally sensitive gatekeeper, a unique drug delivery system can be produced. A novel material that incorporates zinc-doped iron oxide nanocrystals within a mesoporous silica framework that has been surface-modified with pseudorotaxanes is described. Upon application of an AC magnetic field, the nanocrystals generate local internal heating, causing the molecular machines to disassemble and allowing the cargos (drugs) to be released. When breast cancer cells (MDA-MB-231) were treated with doxorubicin-loaded particles and exposed to an AC field, cell death occurred. This material promises to be a noninvasive, externally controlled drug delivery system with cancer-killing properties. © 2010 American Chemical Society. |
Persistent Identifier | http://hdl.handle.net/10722/333669 |
ISSN | 2023 Impact Factor: 14.4 2023 SCImago Journal Rankings: 5.489 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Thomas, Courtney R. | - |
dc.contributor.author | Ferris, Daniel P. | - |
dc.contributor.author | Lee, Jae Hyun | - |
dc.contributor.author | Choi, Eunjoo | - |
dc.contributor.author | Cho, Mi Hyeon | - |
dc.contributor.author | Kim, Eun Sook | - |
dc.contributor.author | Stoddart, J. Fraser | - |
dc.contributor.author | Shin, Jeon Soo | - |
dc.contributor.author | Cheon, Jinwoo | - |
dc.contributor.author | Zink, Jeffrey I. | - |
dc.date.accessioned | 2023-10-06T05:21:27Z | - |
dc.date.available | 2023-10-06T05:21:27Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Journal of the American Chemical Society, 2010, v. 132, n. 31, p. 10623-10625 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | http://hdl.handle.net/10722/333669 | - |
dc.description.abstract | Mesoporous silica nanoparticles are useful nanomaterials that have demonstrated the ability to contain and release cargos with mediation by gatekeepers. Magnetic nanocrystals have the ability to exhibit hyperthermic effects when placed in an oscillating magnetic field. In a system combining these two materials and a thermally sensitive gatekeeper, a unique drug delivery system can be produced. A novel material that incorporates zinc-doped iron oxide nanocrystals within a mesoporous silica framework that has been surface-modified with pseudorotaxanes is described. Upon application of an AC magnetic field, the nanocrystals generate local internal heating, causing the molecular machines to disassemble and allowing the cargos (drugs) to be released. When breast cancer cells (MDA-MB-231) were treated with doxorubicin-loaded particles and exposed to an AC field, cell death occurred. This material promises to be a noninvasive, externally controlled drug delivery system with cancer-killing properties. © 2010 American Chemical Society. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of the American Chemical Society | - |
dc.title | Noninvasive remote-controlled release of drug molecules in vitro using magnetic actuation of mechanized nanoparticles | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/ja1022267 | - |
dc.identifier.pmid | 20681678 | - |
dc.identifier.scopus | eid_2-s2.0-77955382309 | - |
dc.identifier.volume | 132 | - |
dc.identifier.issue | 31 | - |
dc.identifier.spage | 10623 | - |
dc.identifier.epage | 10625 | - |
dc.identifier.eissn | 1520-5126 | - |
dc.identifier.isi | WOS:000280692200003 | - |