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- Publisher Website: 10.1021/jacs.5b08656
- Scopus: eid_2-s2.0-84945252801
- PMID: 26457341
- WOS: WOS:000363438600011
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Article: Allosteric Modulation of Substrate Binding within a Tetracationic Molecular Receptor
Title | Allosteric Modulation of Substrate Binding within a Tetracationic Molecular Receptor |
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Authors | |
Issue Date | 2015 |
Citation | Journal of the American Chemical Society, 2015, v. 137, n. 41, p. 13252-13255 How to Cite? |
Abstract | The synthesis and recognition phenomena of a tetracationic molecular receptor that possesses a nanometer-sized molecular cavity are described. The host-guest properties of the molecular receptor can be tuned and modulated allosterically, where the association of a heterotropic effector at the periphery of the molecule serves to modulate its affinity for the globular, electron-rich guest that resides within its molecular cavity. This stimuli-responsive host-guest behavior was observed in both the solution phase and the crystalline solid state, and can be reversed with high fidelity by sequestration of the effector molecule. |
Persistent Identifier | http://hdl.handle.net/10722/333688 |
ISSN | 2023 Impact Factor: 14.4 2023 SCImago Journal Rankings: 5.489 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Henkelis, James J. | - |
dc.contributor.author | Blackburn, Anthea K. | - |
dc.contributor.author | Dale, Edward J. | - |
dc.contributor.author | Vermeulen, Nicolaas A. | - |
dc.contributor.author | Nassar, Majed S. | - |
dc.contributor.author | Stoddart, J. Fraser | - |
dc.date.accessioned | 2023-10-06T05:21:36Z | - |
dc.date.available | 2023-10-06T05:21:36Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Journal of the American Chemical Society, 2015, v. 137, n. 41, p. 13252-13255 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | http://hdl.handle.net/10722/333688 | - |
dc.description.abstract | The synthesis and recognition phenomena of a tetracationic molecular receptor that possesses a nanometer-sized molecular cavity are described. The host-guest properties of the molecular receptor can be tuned and modulated allosterically, where the association of a heterotropic effector at the periphery of the molecule serves to modulate its affinity for the globular, electron-rich guest that resides within its molecular cavity. This stimuli-responsive host-guest behavior was observed in both the solution phase and the crystalline solid state, and can be reversed with high fidelity by sequestration of the effector molecule. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of the American Chemical Society | - |
dc.title | Allosteric Modulation of Substrate Binding within a Tetracationic Molecular Receptor | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/jacs.5b08656 | - |
dc.identifier.pmid | 26457341 | - |
dc.identifier.scopus | eid_2-s2.0-84945252801 | - |
dc.identifier.volume | 137 | - |
dc.identifier.issue | 41 | - |
dc.identifier.spage | 13252 | - |
dc.identifier.epage | 13255 | - |
dc.identifier.eissn | 1520-5126 | - |
dc.identifier.isi | WOS:000363438600011 | - |