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Article: Conformation Dependent Architectures of Assembled Antimicrobial Peptides with Enhanced Antimicrobial Ability

TitleConformation Dependent Architectures of Assembled Antimicrobial Peptides with Enhanced Antimicrobial Ability
Authors
Keywordsantimicrobial peptides
antimicrobial resistance
conformation
nanostructures
self-assembly
Issue Date13-Aug-2023
PublisherWiley
Citation
Advanced Healthcare Materials, 2023 How to Cite?
Abstract

Antimicrobial peptides (AMPs) are a developing class of natural and synthetic oligopeptides with host defense mechanisms against a broad spectrum of microorganisms. With in-depth research on the structural conformations of AMPs, synthesis or modification of peptides has shown great potential in effectively obtaining new therapeutic agents with improved physicochemical and biological properties. Notably, AMPs with self-assembled properties have gradually become a hot research topic for various biomedical applications. Compared to monomeric peptides, these peptides can exist in diverse forms (e.g., nanoparticles, nanorods, and nanofibers) and possess several advantages, such as high stability, good biocompatibility, and potent biological functions, after forming aggregates under specific conditions. In particular, the stability and antibacterial property of these AMPs can be modulated by rationally regulating the peptide sequences to promote self-assembly, leading to the reconstruction of molecular structure and spatial orientation while introducing some peptide fragments into the scaffolds. In this work, four self-assembled AMPs are developed, and the relationship between their chemical structures and antibacterial activity is explored extensively through different experiments. Importantly, the evaluation of antibacterial performance in both in vitro and in vivo studies has provided a general guide for using self-assembled AMPs in subsequent treatments for combating bacterial infections.


Persistent Identifierhttp://hdl.handle.net/10722/333947
ISSN
2023 Impact Factor: 10.0
2023 SCImago Journal Rankings: 2.337
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLan, XM-
dc.contributor.authorZhong, J-
dc.contributor.authorHuang, R-
dc.contributor.authorLiu, YH-
dc.contributor.authorMa, XW-
dc.contributor.authorLi, X-
dc.contributor.authorZhao, D-
dc.contributor.authorQing, GC-
dc.contributor.authorZhang, YX-
dc.contributor.authorLiu, L-
dc.contributor.authorWang, JJ-
dc.contributor.authorMa, X-
dc.contributor.authorLuo, T-
dc.contributor.authorGuo, WS-
dc.contributor.authorWang, YJ-
dc.contributor.authorLi, LL-
dc.contributor.authorSu, YX-
dc.contributor.authorLiang, XJ-
dc.date.accessioned2023-10-10T03:14:49Z-
dc.date.available2023-10-10T03:14:49Z-
dc.date.issued2023-08-13-
dc.identifier.citationAdvanced Healthcare Materials, 2023-
dc.identifier.issn2192-2640-
dc.identifier.urihttp://hdl.handle.net/10722/333947-
dc.description.abstract<p>Antimicrobial peptides (AMPs) are a developing class of natural and synthetic oligopeptides with host defense mechanisms against a broad spectrum of microorganisms. With in-depth research on the structural conformations of AMPs, synthesis or modification of peptides has shown great potential in effectively obtaining new therapeutic agents with improved physicochemical and biological properties. Notably, AMPs with self-assembled properties have gradually become a hot research topic for various biomedical applications. Compared to monomeric peptides, these peptides can exist in diverse forms (e.g., nanoparticles, nanorods, and nanofibers) and possess several advantages, such as high stability, good biocompatibility, and potent biological functions, after forming aggregates under specific conditions. In particular, the stability and antibacterial property of these AMPs can be modulated by rationally regulating the peptide sequences to promote self-assembly, leading to the reconstruction of molecular structure and spatial orientation while introducing some peptide fragments into the scaffolds. In this work, four self-assembled AMPs are developed, and the relationship between their chemical structures and antibacterial activity is explored extensively through different experiments. Importantly, the evaluation of antibacterial performance in both in vitro and in vivo studies has provided a general guide for using self-assembled AMPs in subsequent treatments for combating bacterial infections.</p>-
dc.languageeng-
dc.publisherWiley-
dc.relation.ispartofAdvanced Healthcare Materials-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectantimicrobial peptides-
dc.subjectantimicrobial resistance-
dc.subjectconformation-
dc.subjectnanostructures-
dc.subjectself-assembly-
dc.titleConformation Dependent Architectures of Assembled Antimicrobial Peptides with Enhanced Antimicrobial Ability-
dc.typeArticle-
dc.identifier.doi10.1002/adhm.202301688-
dc.identifier.scopuseid_2-s2.0-85167733938-
dc.identifier.eissn2192-2659-
dc.identifier.isiWOS:001047350700001-
dc.identifier.issnl2192-2640-

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