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- Publisher Website: 10.1021/ja038702m
- Scopus: eid_2-s2.0-1042299851
- PMID: 14759216
- WOS: WOS:000188834900054
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Article: An Investigation of the Mechanisms of Electronic Sensing of Protein Adsorption on Carbon Nanotube Devices
Title | An Investigation of the Mechanisms of Electronic Sensing of Protein Adsorption on Carbon Nanotube Devices |
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Authors | |
Issue Date | 2004 |
Citation | Journal of the American Chemical Society, 2004, v. 126, n. 5, p. 1563-1568 How to Cite? |
Abstract | It has been reported that protein adsorption on single-walled carbon nanotube field effect transistors (FETs) leads to appreciable changes in the electrical conductance of the devices, a phenomenon that can be exploited for label-free detection of biomolecules with a high potential for miniaturization. This work presents an elucidation of the electronic biosensing mechanisms with a newly developed microarray of nanotube "micromat" sensors. Chemical functionalization schemes are devised to block selected components of the devices from protein adsorption, self-assembled monolayers (SAMs) of methoxy(poly-(ethylene glycol))thiol (mPEG-SH) on the metal electrodes (Au, Pd) and PEG-containing surfactants on the nanotubes. Extensive characterization reveals that electronic effects occurring at the metal-nanotube contacts due to protein adsorption constitute a more significant contribution to the electronic biosensing signal than adsorption solely along the exposed lengths of the nanotubes. |
Persistent Identifier | http://hdl.handle.net/10722/334089 |
ISSN | 2023 Impact Factor: 14.4 2023 SCImago Journal Rankings: 5.489 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chen, Robert J. | - |
dc.contributor.author | Choi, Hee Cheul | - |
dc.contributor.author | Bangsaruntip, Sarunya | - |
dc.contributor.author | Yenilmez, Erhan | - |
dc.contributor.author | Tang, Xiaowu | - |
dc.contributor.author | Wang, Qian | - |
dc.contributor.author | Chang, Ying Lan | - |
dc.contributor.author | Dai, Hongjie | - |
dc.date.accessioned | 2023-10-20T06:45:33Z | - |
dc.date.available | 2023-10-20T06:45:33Z | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Journal of the American Chemical Society, 2004, v. 126, n. 5, p. 1563-1568 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | http://hdl.handle.net/10722/334089 | - |
dc.description.abstract | It has been reported that protein adsorption on single-walled carbon nanotube field effect transistors (FETs) leads to appreciable changes in the electrical conductance of the devices, a phenomenon that can be exploited for label-free detection of biomolecules with a high potential for miniaturization. This work presents an elucidation of the electronic biosensing mechanisms with a newly developed microarray of nanotube "micromat" sensors. Chemical functionalization schemes are devised to block selected components of the devices from protein adsorption, self-assembled monolayers (SAMs) of methoxy(poly-(ethylene glycol))thiol (mPEG-SH) on the metal electrodes (Au, Pd) and PEG-containing surfactants on the nanotubes. Extensive characterization reveals that electronic effects occurring at the metal-nanotube contacts due to protein adsorption constitute a more significant contribution to the electronic biosensing signal than adsorption solely along the exposed lengths of the nanotubes. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of the American Chemical Society | - |
dc.title | An Investigation of the Mechanisms of Electronic Sensing of Protein Adsorption on Carbon Nanotube Devices | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/ja038702m | - |
dc.identifier.pmid | 14759216 | - |
dc.identifier.scopus | eid_2-s2.0-1042299851 | - |
dc.identifier.volume | 126 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 1563 | - |
dc.identifier.epage | 1568 | - |
dc.identifier.isi | WOS:000188834900054 | - |