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Article: PEGylated nanographene oxide for delivery of water-insoluble cancer drugs

TitlePEGylated nanographene oxide for delivery of water-insoluble cancer drugs
Authors
Issue Date2008
Citation
Journal of the American Chemical Society, 2008, v. 130, n. 33, p. 10876-10877 How to Cite?
AbstractIt is known that many potent, often aromatic drugs are water insoluble, which has hampered their use for disease treatment. In this work, we functionalized nanographene oxide (NGO), a novel graphitic material, with branched polyethylene glycol (PEG) to obtain a biocompatible NGO-PEG conjugate stable in various biological solutions, and used them for attaching hydrophobic aromatic molecules including a camptothecin (CPT) analogue, SN38, noncovalently via π-π stacking. The resulting NGO-PEG-SN38 complex exhibited excellent water solubility while maintaining its high cancer cell killing potency similar to that of the free SN38 molecules in organic solvents. The efficacy of NGO-PEG-SN38 was far higher than that of irinotecan (CPT-11), a FDA-approved water soluble SN38 prodrug used for the treatment of colon cancer. Our results showed that graphene is a novel class of material promising for biological applications including future in vivo cancer treatment with various aromatic, low-solubility drugs. Copyright © 2008 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/334179
ISSN
2023 Impact Factor: 14.4
2023 SCImago Journal Rankings: 5.489
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, Zhuang-
dc.contributor.authorRobinson, Joshua T.-
dc.contributor.authorSun, Xiaoming-
dc.contributor.authorDai, Hongjie-
dc.date.accessioned2023-10-20T06:46:18Z-
dc.date.available2023-10-20T06:46:18Z-
dc.date.issued2008-
dc.identifier.citationJournal of the American Chemical Society, 2008, v. 130, n. 33, p. 10876-10877-
dc.identifier.issn0002-7863-
dc.identifier.urihttp://hdl.handle.net/10722/334179-
dc.description.abstractIt is known that many potent, often aromatic drugs are water insoluble, which has hampered their use for disease treatment. In this work, we functionalized nanographene oxide (NGO), a novel graphitic material, with branched polyethylene glycol (PEG) to obtain a biocompatible NGO-PEG conjugate stable in various biological solutions, and used them for attaching hydrophobic aromatic molecules including a camptothecin (CPT) analogue, SN38, noncovalently via π-π stacking. The resulting NGO-PEG-SN38 complex exhibited excellent water solubility while maintaining its high cancer cell killing potency similar to that of the free SN38 molecules in organic solvents. The efficacy of NGO-PEG-SN38 was far higher than that of irinotecan (CPT-11), a FDA-approved water soluble SN38 prodrug used for the treatment of colon cancer. Our results showed that graphene is a novel class of material promising for biological applications including future in vivo cancer treatment with various aromatic, low-solubility drugs. Copyright © 2008 American Chemical Society.-
dc.languageeng-
dc.relation.ispartofJournal of the American Chemical Society-
dc.titlePEGylated nanographene oxide for delivery of water-insoluble cancer drugs-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/ja803688x-
dc.identifier.pmid18661992-
dc.identifier.scopuseid_2-s2.0-50249123111-
dc.identifier.volume130-
dc.identifier.issue33-
dc.identifier.spage10876-
dc.identifier.epage10877-
dc.identifier.isiWOS:000258415900023-

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