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Article: A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice

TitleA route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice
Authors
Issue Date2009
Citation
Nature Nanotechnology, 2009, v. 4, n. 11, p. 773-780 How to Cite?
AbstractThe near-infrared photoluminescence intrinsic to semiconducting single-walled carbon nanotubes is ideal for biological imaging owing to the low autofluorescence and deep tissue penetration in the near-infrared region beyond 1μm. However, biocompatible single-walled carbon nanotubes with high quantum yield have been elusive. Here, we show that sonicating single-walled carbon nanotubes with sodium cholate, followed by surfactant exchange to form phospholipid-polyethylene glycol coated nanotubes, produces in vivo imaging agents that are both bright and biocompatible. The exchange procedure is better than directly sonicating the tubes with the phospholipid-polyethylene glycol, because it results in less damage to the nanotubes and improves the quantum yield. We show whole-animal in vivo imaging using an InGaAs camera in the 1-1.7μm spectral range by detecting the intrinsic near-infrared photoluminescence of the exchange single-walled carbon nanotubes at a low dose (17mgl-1 injected dose). The deep tissue penetration and low autofluorescence background allowed high-resolution intravital microscopy imaging of tumour vessels beneath thick skin. © 2009 Macmillan Publishers Limited.
Persistent Identifierhttp://hdl.handle.net/10722/334204
ISSN
2023 Impact Factor: 38.1
2023 SCImago Journal Rankings: 14.577
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWelsher, Kevin-
dc.contributor.authorLiu, Zhuang-
dc.contributor.authorSherlock, Sarah P.-
dc.contributor.authorRobinson, Joshua Tucker-
dc.contributor.authorChen, Zhuo-
dc.contributor.authorDaranciang, Dan-
dc.contributor.authorDai, Hongjie-
dc.date.accessioned2023-10-20T06:46:28Z-
dc.date.available2023-10-20T06:46:28Z-
dc.date.issued2009-
dc.identifier.citationNature Nanotechnology, 2009, v. 4, n. 11, p. 773-780-
dc.identifier.issn1748-3387-
dc.identifier.urihttp://hdl.handle.net/10722/334204-
dc.description.abstractThe near-infrared photoluminescence intrinsic to semiconducting single-walled carbon nanotubes is ideal for biological imaging owing to the low autofluorescence and deep tissue penetration in the near-infrared region beyond 1μm. However, biocompatible single-walled carbon nanotubes with high quantum yield have been elusive. Here, we show that sonicating single-walled carbon nanotubes with sodium cholate, followed by surfactant exchange to form phospholipid-polyethylene glycol coated nanotubes, produces in vivo imaging agents that are both bright and biocompatible. The exchange procedure is better than directly sonicating the tubes with the phospholipid-polyethylene glycol, because it results in less damage to the nanotubes and improves the quantum yield. We show whole-animal in vivo imaging using an InGaAs camera in the 1-1.7μm spectral range by detecting the intrinsic near-infrared photoluminescence of the exchange single-walled carbon nanotubes at a low dose (17mgl-1 injected dose). The deep tissue penetration and low autofluorescence background allowed high-resolution intravital microscopy imaging of tumour vessels beneath thick skin. © 2009 Macmillan Publishers Limited.-
dc.languageeng-
dc.relation.ispartofNature Nanotechnology-
dc.titleA route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/nnano.2009.294-
dc.identifier.pmid19893526-
dc.identifier.scopuseid_2-s2.0-70449574483-
dc.identifier.volume4-
dc.identifier.issue11-
dc.identifier.spage773-
dc.identifier.epage780-
dc.identifier.eissn1748-3395-
dc.identifier.isiWOS:000272413500022-

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