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Article: Multifunctional FeCo-graphitic carbon nanocrystals for combined imaging, drug delivery and tumor-specific photothermal therapy in mice

TitleMultifunctional FeCo-graphitic carbon nanocrystals for combined imaging, drug delivery and tumor-specific photothermal therapy in mice
Authors
Keywordsdoxorubicin
hyperthermia
magnetic resonance imaging
Nanocrystals
photothermal therapy
Issue Date2011
Citation
Nano Research, 2011, v. 4, n. 12, p. 1248-1260 How to Cite?
AbstractUltrasmall FeCo-graphitic carbon shell nanocrystals (FeCo/GC) are promising multifunctional materials capable of highly efficient drug delivery in vitro and magnetic resonance imaging in vivo. In this work, we demonstrate the use of FeCo/GC for highly effective cancer therapy through combined drug delivery, tumor-selective near-infrared photothermal therapy, and cancer imaging of a 4T1 syngeneic breast cancer model. The graphitic carbon shell of the ~4 nm FeCo/GC readily loads doxorubicin (DOX) via π-π stacking and absorbs near-infrared light giving photothermal heating. When used for cancer treatment, intravenously administrated FeCo/GC-DOX led to complete tumor regression in 45% of mice when combined with 20 min of near-infrared laser irradiation selectively heating the tumor to 43-45 °C. In addition, the use of FeCo/GC-DOX results in reduced systemic toxicity compared with free DOX and appears to be safe in mice monitored for over 1 yr. FeCo/GC-DOX is shown to be a highly integrated nanoparticle system for synergistic cancer therapy leading to tumor regression of a highly aggressive tumor model.[InlineMediaObject not available: see fulltext.] © 2011 Tsinghua University Press and Springer-Verlag Berlin Heidelberg.
Persistent Identifierhttp://hdl.handle.net/10722/334266
ISSN
2023 Impact Factor: 9.5
2023 SCImago Journal Rankings: 2.539
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSherlock, Sarah P.-
dc.contributor.authorDai, Hongjie-
dc.date.accessioned2023-10-20T06:46:54Z-
dc.date.available2023-10-20T06:46:54Z-
dc.date.issued2011-
dc.identifier.citationNano Research, 2011, v. 4, n. 12, p. 1248-1260-
dc.identifier.issn1998-0124-
dc.identifier.urihttp://hdl.handle.net/10722/334266-
dc.description.abstractUltrasmall FeCo-graphitic carbon shell nanocrystals (FeCo/GC) are promising multifunctional materials capable of highly efficient drug delivery in vitro and magnetic resonance imaging in vivo. In this work, we demonstrate the use of FeCo/GC for highly effective cancer therapy through combined drug delivery, tumor-selective near-infrared photothermal therapy, and cancer imaging of a 4T1 syngeneic breast cancer model. The graphitic carbon shell of the ~4 nm FeCo/GC readily loads doxorubicin (DOX) via π-π stacking and absorbs near-infrared light giving photothermal heating. When used for cancer treatment, intravenously administrated FeCo/GC-DOX led to complete tumor regression in 45% of mice when combined with 20 min of near-infrared laser irradiation selectively heating the tumor to 43-45 °C. In addition, the use of FeCo/GC-DOX results in reduced systemic toxicity compared with free DOX and appears to be safe in mice monitored for over 1 yr. FeCo/GC-DOX is shown to be a highly integrated nanoparticle system for synergistic cancer therapy leading to tumor regression of a highly aggressive tumor model.[InlineMediaObject not available: see fulltext.] © 2011 Tsinghua University Press and Springer-Verlag Berlin Heidelberg.-
dc.languageeng-
dc.relation.ispartofNano Research-
dc.subjectdoxorubicin-
dc.subjecthyperthermia-
dc.subjectmagnetic resonance imaging-
dc.subjectNanocrystals-
dc.subjectphotothermal therapy-
dc.titleMultifunctional FeCo-graphitic carbon nanocrystals for combined imaging, drug delivery and tumor-specific photothermal therapy in mice-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s12274-011-0176-z-
dc.identifier.scopuseid_2-s2.0-83055184243-
dc.identifier.volume4-
dc.identifier.issue12-
dc.identifier.spage1248-
dc.identifier.epage1260-
dc.identifier.eissn1998-0000-
dc.identifier.isiWOS:000297913800009-

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