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Article: Shape matters: Intravital microscopy reveals surprising geometrical dependence for nanoparticles in tumor models of extravasation

TitleShape matters: Intravital microscopy reveals surprising geometrical dependence for nanoparticles in tumor models of extravasation
Authors
Keywordscancer
extravasation
intravital microscopy
nanoparticle geometry
quantum dots
Single-walled carbon nanotubes
Issue Date2012
Citation
Nano Letters, 2012, v. 12, n. 7, p. 3369-3377 How to Cite?
AbstractDelivery is one of the most critical obstacles confronting nanoparticle use in cancer diagnosis and therapy. For most oncological applications, nanoparticles must extravasate in order to reach tumor cells and perform their designated task. However, little understanding exists regarding the effect of nanoparticle shape on extravasation. Herein we use real-time intravital microscopic imaging to meticulously examine how two different nanoparticles behave across three different murine tumor models. The study quantitatively demonstrates that high-aspect ratio single-walled carbon nanotubes (SWNTs) display extravasational behavior surprisingly different from, and counterintuitive to, spherical nanoparticles although the nanoparticles have similar surface coatings, area, and charge. This work quantitatively indicates that nanoscale extravasational competence is highly dependent on nanoparticle geometry and is heterogeneous. © 2012 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/334283
ISSN
2023 Impact Factor: 9.6
2023 SCImago Journal Rankings: 3.411
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSmith, Bryan Ronain-
dc.contributor.authorKempen, Paul-
dc.contributor.authorBouley, Donna-
dc.contributor.authorXu, Alexander-
dc.contributor.authorLiu, Zhuang-
dc.contributor.authorMelosh, Nicholas-
dc.contributor.authorDai, Hongjie-
dc.contributor.authorSinclair, Robert-
dc.contributor.authorGambhir, Sanjiv Sam-
dc.date.accessioned2023-10-20T06:47:01Z-
dc.date.available2023-10-20T06:47:01Z-
dc.date.issued2012-
dc.identifier.citationNano Letters, 2012, v. 12, n. 7, p. 3369-3377-
dc.identifier.issn1530-6984-
dc.identifier.urihttp://hdl.handle.net/10722/334283-
dc.description.abstractDelivery is one of the most critical obstacles confronting nanoparticle use in cancer diagnosis and therapy. For most oncological applications, nanoparticles must extravasate in order to reach tumor cells and perform their designated task. However, little understanding exists regarding the effect of nanoparticle shape on extravasation. Herein we use real-time intravital microscopic imaging to meticulously examine how two different nanoparticles behave across three different murine tumor models. The study quantitatively demonstrates that high-aspect ratio single-walled carbon nanotubes (SWNTs) display extravasational behavior surprisingly different from, and counterintuitive to, spherical nanoparticles although the nanoparticles have similar surface coatings, area, and charge. This work quantitatively indicates that nanoscale extravasational competence is highly dependent on nanoparticle geometry and is heterogeneous. © 2012 American Chemical Society.-
dc.languageeng-
dc.relation.ispartofNano Letters-
dc.subjectcancer-
dc.subjectextravasation-
dc.subjectintravital microscopy-
dc.subjectnanoparticle geometry-
dc.subjectquantum dots-
dc.subjectSingle-walled carbon nanotubes-
dc.titleShape matters: Intravital microscopy reveals surprising geometrical dependence for nanoparticles in tumor models of extravasation-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/nl204175t-
dc.identifier.pmid22650417-
dc.identifier.scopuseid_2-s2.0-84863831041-
dc.identifier.volume12-
dc.identifier.issue7-
dc.identifier.spage3369-
dc.identifier.epage3377-
dc.identifier.eissn1530-6992-
dc.identifier.isiWOS:000306296200004-

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