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Article: Multifunctional in vivo vascular imaging using near-infrared II fluorescence

TitleMultifunctional in vivo vascular imaging using near-infrared II fluorescence
Authors
Issue Date2012
Citation
Nature Medicine, 2012, v. 18, n. 12, p. 1841-1846 How to Cite?
AbstractIn vivo real-time epifluorescence imaging of mouse hind limb vasculatures in the second near-infrared region (NIR-II) is performed using single-walled carbon nanotubes as fluorophores. Both high spatial (∼30 μm) and temporal (<200 ms per frame) resolution for small-vessel imaging are achieved at 1-3 mm deep in the hind limb owing to the beneficial NIR-II optical window that affords deep anatomical penetration and low scattering. This spatial resolution is unattainable by traditional NIR imaging (NIR-I) or microscopic computed tomography, and the temporal resolution far exceeds scanning microscopic imaging techniques. Arterial and venous vessels are unambiguously differentiated using a dynamic contrast-enhanced NIR-II imaging technique on the basis of their distinct hemodynamics. Further, the deep tissue penetration and high spatial and temporal resolution of NIR-II imaging allow for precise quantifications of blood velocity in both normal and ischemic femoral arteries, which are beyond the capabilities of ultrasonography at lower blood velocities. © 2012 Nature America, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/334301
ISSN
2023 Impact Factor: 58.7
2023 SCImago Journal Rankings: 19.045
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHong, Guosong-
dc.contributor.authorLee, Jerry C.-
dc.contributor.authorRobinson, Joshua T.-
dc.contributor.authorRaaz, Uwe-
dc.contributor.authorXie, Liming-
dc.contributor.authorHuang, Ngan F.-
dc.contributor.authorCooke, John P.-
dc.contributor.authorDai, Hongjie-
dc.date.accessioned2023-10-20T06:47:09Z-
dc.date.available2023-10-20T06:47:09Z-
dc.date.issued2012-
dc.identifier.citationNature Medicine, 2012, v. 18, n. 12, p. 1841-1846-
dc.identifier.issn1078-8956-
dc.identifier.urihttp://hdl.handle.net/10722/334301-
dc.description.abstractIn vivo real-time epifluorescence imaging of mouse hind limb vasculatures in the second near-infrared region (NIR-II) is performed using single-walled carbon nanotubes as fluorophores. Both high spatial (∼30 μm) and temporal (<200 ms per frame) resolution for small-vessel imaging are achieved at 1-3 mm deep in the hind limb owing to the beneficial NIR-II optical window that affords deep anatomical penetration and low scattering. This spatial resolution is unattainable by traditional NIR imaging (NIR-I) or microscopic computed tomography, and the temporal resolution far exceeds scanning microscopic imaging techniques. Arterial and venous vessels are unambiguously differentiated using a dynamic contrast-enhanced NIR-II imaging technique on the basis of their distinct hemodynamics. Further, the deep tissue penetration and high spatial and temporal resolution of NIR-II imaging allow for precise quantifications of blood velocity in both normal and ischemic femoral arteries, which are beyond the capabilities of ultrasonography at lower blood velocities. © 2012 Nature America, Inc.-
dc.languageeng-
dc.relation.ispartofNature Medicine-
dc.titleMultifunctional in vivo vascular imaging using near-infrared II fluorescence-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/nm.2995-
dc.identifier.pmid23160236-
dc.identifier.scopuseid_2-s2.0-84870955323-
dc.identifier.volume18-
dc.identifier.issue12-
dc.identifier.spage1841-
dc.identifier.epage1846-
dc.identifier.eissn1546-170X-
dc.identifier.isiWOS:000311999800033-

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