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Article: Ultra-low doses of chirality sorted (6,5) carbon nanotubes for simultaneous tumor imaging and photothermal therapy

TitleUltra-low doses of chirality sorted (6,5) carbon nanotubes for simultaneous tumor imaging and photothermal therapy
Authors
Keywordsnanoelectronics
photothermal therapy
single-walled carbon nanotubes
Issue Date2013
Citation
ACS Nano, 2013, v. 7, n. 4, p. 3644-3652 How to Cite?
AbstractSingle-walled carbon nanotubes (SWCNTs) exhibit intrinsic fluorescence and strong optical absorption in the near-infrared (NIR) biological window (0.7-1.4 μm), rendering them ideal for in vivo imaging and photothermal therapy. Advances in SWCNT sorting have led to improved nanoelectronics and are promising for nanomedicine. To date, SWCNTs used in vivo consist of heterogeneous mixtures of nanotubes and only a small subset of chirality nanotubes fluoresces or heats under a NIR laser. Here, we demonstrate that separated (6,5) SWCNTs exchanged into a biocompatible surfactant, C18-PMH-mPEG, are more than 6-fold brighter in photoluminescence on the per mass basis, afford clear tumor imaging, and reach requisite photothermal tumor ablation temperatures with a >10-fold lower injected dose than as-synthesized SWCNT mixtures while exhibiting relatively low (6,5) accumulation in the reticuloendothelial system. The intravenous injection of ∼4 μg of (6,5) SWCNTs per mouse (0.254 mg/kg) for dual imaging/photothermal therapy is, by far, the lowest reported dose for nanoparticle-based in vivo therapeutics. © 2013 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/334316
ISSN
2023 Impact Factor: 15.8
2023 SCImago Journal Rankings: 4.593
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAntaris, Alexander L.-
dc.contributor.authorRobinson, Joshua T.-
dc.contributor.authorYaghi, Omar K.-
dc.contributor.authorHong, Guosong-
dc.contributor.authorDiao, Shuo-
dc.contributor.authorLuong, Richard-
dc.contributor.authorDai, Hongjie-
dc.date.accessioned2023-10-20T06:47:15Z-
dc.date.available2023-10-20T06:47:15Z-
dc.date.issued2013-
dc.identifier.citationACS Nano, 2013, v. 7, n. 4, p. 3644-3652-
dc.identifier.issn1936-0851-
dc.identifier.urihttp://hdl.handle.net/10722/334316-
dc.description.abstractSingle-walled carbon nanotubes (SWCNTs) exhibit intrinsic fluorescence and strong optical absorption in the near-infrared (NIR) biological window (0.7-1.4 μm), rendering them ideal for in vivo imaging and photothermal therapy. Advances in SWCNT sorting have led to improved nanoelectronics and are promising for nanomedicine. To date, SWCNTs used in vivo consist of heterogeneous mixtures of nanotubes and only a small subset of chirality nanotubes fluoresces or heats under a NIR laser. Here, we demonstrate that separated (6,5) SWCNTs exchanged into a biocompatible surfactant, C18-PMH-mPEG, are more than 6-fold brighter in photoluminescence on the per mass basis, afford clear tumor imaging, and reach requisite photothermal tumor ablation temperatures with a >10-fold lower injected dose than as-synthesized SWCNT mixtures while exhibiting relatively low (6,5) accumulation in the reticuloendothelial system. The intravenous injection of ∼4 μg of (6,5) SWCNTs per mouse (0.254 mg/kg) for dual imaging/photothermal therapy is, by far, the lowest reported dose for nanoparticle-based in vivo therapeutics. © 2013 American Chemical Society.-
dc.languageeng-
dc.relation.ispartofACS Nano-
dc.subjectnanoelectronics-
dc.subjectphotothermal therapy-
dc.subjectsingle-walled carbon nanotubes-
dc.titleUltra-low doses of chirality sorted (6,5) carbon nanotubes for simultaneous tumor imaging and photothermal therapy-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/nn4006472-
dc.identifier.pmid23521224-
dc.identifier.scopuseid_2-s2.0-84876585232-
dc.identifier.volume7-
dc.identifier.issue4-
dc.identifier.spage3644-
dc.identifier.epage3652-
dc.identifier.eissn1936-086X-
dc.identifier.isiWOS:000318143300081-

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