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Article: Ly108 expression distinguishes subsets of invariant NKT cells that help autoantibody production and secrete IL-21 from those that secrete IL-17 in lupus prone NZB/W mice

TitleLy108 expression distinguishes subsets of invariant NKT cells that help autoantibody production and secrete IL-21 from those that secrete IL-17 in lupus prone NZB/W mice
Authors
KeywordsAutoantibodies
IL-17
IL-21
Natural killer T cells
Systemic lupus erythematosus
Issue Date2014
Citation
Journal of Autoimmunity, 2014, v. 50, p. 87-98 How to Cite?
AbstractLupus is a systemic autoimmune disease characterized by anti-nuclear antibodies in humans and genetically susceptible NZB/W mice that can cause immune complex glomerulonephritis. T cells contribute to lupus pathogenesis by secreting pro-inflammatory cytokines such as IL-17, and by interacting with B cells and secreting helper factors such as IL-21 that promote production of IgG autoantibodies. In the current study, we determined whether purified NKT cells or far more numerous conventional non-NKT cells in the spleen of NZB/W female mice secrete IL-17 and/or IL-21 after TCR activation invitro, and provide help for spontaneous IgG autoantibody production by purified splenic CD19+ B cells. Whereas invariant NKT cells secreted large amounts of IL-17 and IL-21, and helped B cells, non-NKT cells did not. The subset of IL-17 secreting NZB/W NKT cells expressed the Ly108loCD4-NK1.1- phenotype, whereas the IL-21 secreting subset expressed the Ly108hiCD4+NK1.1- phenotype and helped B cells secrete a variety of IgG anti-nuclear antibodies. α-galactocylceramide enhanced the helper activity of NZB/W and B6.Sle1b NKT cells for IgG autoantibody secretion by syngeneic B cells. In conclusion, different subsets of iNKT cells from mice with genetic susceptibility to lupus can contribute to pathogenesis by secreting pro-inflammatory cytokines and helping autoantibody production. © 2014 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/334357
ISSN
2023 Impact Factor: 7.9
2023 SCImago Journal Rankings: 2.558
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTang, Xiaobin-
dc.contributor.authorZhang, Bo-
dc.contributor.authorJarrell, Justin A.-
dc.contributor.authorPrice, Jordan V.-
dc.contributor.authorDai, Hongjie-
dc.contributor.authorUtz, Paul J.-
dc.contributor.authorStrober, Samuel-
dc.date.accessioned2023-10-20T06:47:34Z-
dc.date.available2023-10-20T06:47:34Z-
dc.date.issued2014-
dc.identifier.citationJournal of Autoimmunity, 2014, v. 50, p. 87-98-
dc.identifier.issn0896-8411-
dc.identifier.urihttp://hdl.handle.net/10722/334357-
dc.description.abstractLupus is a systemic autoimmune disease characterized by anti-nuclear antibodies in humans and genetically susceptible NZB/W mice that can cause immune complex glomerulonephritis. T cells contribute to lupus pathogenesis by secreting pro-inflammatory cytokines such as IL-17, and by interacting with B cells and secreting helper factors such as IL-21 that promote production of IgG autoantibodies. In the current study, we determined whether purified NKT cells or far more numerous conventional non-NKT cells in the spleen of NZB/W female mice secrete IL-17 and/or IL-21 after TCR activation invitro, and provide help for spontaneous IgG autoantibody production by purified splenic CD19+ B cells. Whereas invariant NKT cells secreted large amounts of IL-17 and IL-21, and helped B cells, non-NKT cells did not. The subset of IL-17 secreting NZB/W NKT cells expressed the Ly108loCD4-NK1.1- phenotype, whereas the IL-21 secreting subset expressed the Ly108hiCD4+NK1.1- phenotype and helped B cells secrete a variety of IgG anti-nuclear antibodies. α-galactocylceramide enhanced the helper activity of NZB/W and B6.Sle1b NKT cells for IgG autoantibody secretion by syngeneic B cells. In conclusion, different subsets of iNKT cells from mice with genetic susceptibility to lupus can contribute to pathogenesis by secreting pro-inflammatory cytokines and helping autoantibody production. © 2014 Elsevier Ltd.-
dc.languageeng-
dc.relation.ispartofJournal of Autoimmunity-
dc.subjectAutoantibodies-
dc.subjectIL-17-
dc.subjectIL-21-
dc.subjectNatural killer T cells-
dc.subjectSystemic lupus erythematosus-
dc.titleLy108 expression distinguishes subsets of invariant NKT cells that help autoantibody production and secrete IL-21 from those that secrete IL-17 in lupus prone NZB/W mice-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jaut.2014.01.002-
dc.identifier.pmid24508410-
dc.identifier.scopuseid_2-s2.0-84899053889-
dc.identifier.volume50-
dc.identifier.spage87-
dc.identifier.epage98-
dc.identifier.eissn1095-9157-
dc.identifier.isiWOS:000336114600012-

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