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Article: Through-skull fluorescence imaging of the brain in a new near-infrared window

TitleThrough-skull fluorescence imaging of the brain in a new near-infrared window
Authors
Issue Date2014
Citation
Nature Photonics, 2014, v. 8, n. 9, p. 723-730 How to Cite?
AbstractTo date, brain imaging has largely relied on X-ray computed tomography and magnetic resonance angiography, with their limited spatial resolution and long scanning times. Fluorescence-based brain imaging in the visible and traditional near-infrared regions (400-900 nm) is an alternative, but at present it requires craniotomy, cranial windows and skull-thinning techniques, and the penetration depth is limited to 1-2 mm due to light scattering. Here, we report through-scalp and through-skull fluorescence imaging of mouse cerebral vasculature without craniotomy, utilizing the intrinsic photoluminescence of single-walled carbon nanotubes in the 1.3-1.4 μm near-infrared window (NIR-IIa window). Reduced photon scattering in this spectral region allows fluorescence imaging to a depth of >2 mm in mouse brain with sub-10-μm resolution. An imaging rate of ∼5.3 frames per second allows for dynamic recording of blood perfusion in the cerebral vessels with sufficient temporal resolution, providing real-time assessment of a blood flow anomaly in a mouse middle cerebral artery occlusion stroke model. © 2014 Macmillan Publishers Limited. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/334370
ISSN
2023 Impact Factor: 32.3
2023 SCImago Journal Rankings: 11.249
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHong, Guosong-
dc.contributor.authorDiao, Shuo-
dc.contributor.authorChang, Junlei-
dc.contributor.authorAntaris, Alexander L.-
dc.contributor.authorChen, Changxin-
dc.contributor.authorZhang, Bo-
dc.contributor.authorZhao, Su-
dc.contributor.authorAtochin, Dmitriy N.-
dc.contributor.authorHuang, Paul L.-
dc.contributor.authorAndreasson, Katrin I.-
dc.contributor.authorKuo, Calvin J.-
dc.contributor.authorDai, Hongjie-
dc.date.accessioned2023-10-20T06:47:40Z-
dc.date.available2023-10-20T06:47:40Z-
dc.date.issued2014-
dc.identifier.citationNature Photonics, 2014, v. 8, n. 9, p. 723-730-
dc.identifier.issn1749-4885-
dc.identifier.urihttp://hdl.handle.net/10722/334370-
dc.description.abstractTo date, brain imaging has largely relied on X-ray computed tomography and magnetic resonance angiography, with their limited spatial resolution and long scanning times. Fluorescence-based brain imaging in the visible and traditional near-infrared regions (400-900 nm) is an alternative, but at present it requires craniotomy, cranial windows and skull-thinning techniques, and the penetration depth is limited to 1-2 mm due to light scattering. Here, we report through-scalp and through-skull fluorescence imaging of mouse cerebral vasculature without craniotomy, utilizing the intrinsic photoluminescence of single-walled carbon nanotubes in the 1.3-1.4 μm near-infrared window (NIR-IIa window). Reduced photon scattering in this spectral region allows fluorescence imaging to a depth of >2 mm in mouse brain with sub-10-μm resolution. An imaging rate of ∼5.3 frames per second allows for dynamic recording of blood perfusion in the cerebral vessels with sufficient temporal resolution, providing real-time assessment of a blood flow anomaly in a mouse middle cerebral artery occlusion stroke model. © 2014 Macmillan Publishers Limited. All rights reserved.-
dc.languageeng-
dc.relation.ispartofNature Photonics-
dc.titleThrough-skull fluorescence imaging of the brain in a new near-infrared window-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/nphoton.2014.166-
dc.identifier.scopuseid_2-s2.0-84906889401-
dc.identifier.volume8-
dc.identifier.issue9-
dc.identifier.spage723-
dc.identifier.epage730-
dc.identifier.eissn1749-4893-
dc.identifier.isiWOS:000342600100016-

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