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Article: A small-molecule dye for NIR-II imaging

TitleA small-molecule dye for NIR-II imaging
Authors
Issue Date2016
Citation
Nature Materials, 2016, v. 15, n. 2, p. 235-242 How to Cite?
AbstractFluorescent imaging of biological systems in the second near-infrared window (NIR-II) can probe tissue at centimetre depths and achieve micrometre-scale resolution at depths of millimetres. Unfortunately, all current NIR-II fluorophores are excreted slowly and are largely retained within the reticuloendothelial system, making clinical translation nearly impossible. Here, we report a rapidly excreted NIR-II fluorophore (∼90% excreted through the kidneys within 24 h) based on a synthetic 970-Da organic molecule (CH1055). The fluorophore outperformed indocyanine green (ICG) - a clinically approved NIR-I dye - in resolving mouse lymphatic vasculature and sentinel lymphatic mapping near a tumour. High levels of uptake of PEGylated-CH1055 dye were observed in brain tumours in mice, suggesting that the dye was detected at a depth of ∼4 mm. The CH1055 dye also allowed targeted molecular imaging of tumours in vivo when conjugated with anti-EGFR Affibody. Moreover, a superior tumour-to-background signal ratio allowed precise image-guided tumour-removal surgery.
Persistent Identifierhttp://hdl.handle.net/10722/334416
ISSN
2023 Impact Factor: 37.2
2023 SCImago Journal Rankings: 14.231
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAntaris, Alexander L.-
dc.contributor.authorChen, Hao-
dc.contributor.authorCheng, Kai-
dc.contributor.authorSun, Yao-
dc.contributor.authorHong, Guosong-
dc.contributor.authorQu, Chunrong-
dc.contributor.authorDiao, Shuo-
dc.contributor.authorDeng, Zixin-
dc.contributor.authorHu, Xianming-
dc.contributor.authorZhang, Bo-
dc.contributor.authorZhang, Xiaodong-
dc.contributor.authorYaghi, Omar K.-
dc.contributor.authorAlamparambil, Zita R.-
dc.contributor.authorHong, Xuechuan-
dc.contributor.authorCheng, Zhen-
dc.contributor.authorDai, Hongjie-
dc.date.accessioned2023-10-20T06:47:59Z-
dc.date.available2023-10-20T06:47:59Z-
dc.date.issued2016-
dc.identifier.citationNature Materials, 2016, v. 15, n. 2, p. 235-242-
dc.identifier.issn1476-1122-
dc.identifier.urihttp://hdl.handle.net/10722/334416-
dc.description.abstractFluorescent imaging of biological systems in the second near-infrared window (NIR-II) can probe tissue at centimetre depths and achieve micrometre-scale resolution at depths of millimetres. Unfortunately, all current NIR-II fluorophores are excreted slowly and are largely retained within the reticuloendothelial system, making clinical translation nearly impossible. Here, we report a rapidly excreted NIR-II fluorophore (∼90% excreted through the kidneys within 24 h) based on a synthetic 970-Da organic molecule (CH1055). The fluorophore outperformed indocyanine green (ICG) - a clinically approved NIR-I dye - in resolving mouse lymphatic vasculature and sentinel lymphatic mapping near a tumour. High levels of uptake of PEGylated-CH1055 dye were observed in brain tumours in mice, suggesting that the dye was detected at a depth of ∼4 mm. The CH1055 dye also allowed targeted molecular imaging of tumours in vivo when conjugated with anti-EGFR Affibody. Moreover, a superior tumour-to-background signal ratio allowed precise image-guided tumour-removal surgery.-
dc.languageeng-
dc.relation.ispartofNature Materials-
dc.titleA small-molecule dye for NIR-II imaging-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/nmat4476-
dc.identifier.pmid26595119-
dc.identifier.scopuseid_2-s2.0-84955746433-
dc.identifier.volume15-
dc.identifier.issue2-
dc.identifier.spage235-
dc.identifier.epage242-
dc.identifier.eissn1476-4660-
dc.identifier.isiWOS:000368766100030-

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