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Article: Fluorescence imaging in Vivo at wavelengths beyond 1500 nm

TitleFluorescence imaging in Vivo at wavelengths beyond 1500 nm
Authors
Keywordscancer
fluorescence
imaging agents
nanotechnology
near infrared
Issue Date2015
Citation
Angewandte Chemie - International Edition, 2015, v. 54, n. 49, p. 14758-14762 How to Cite?
AbstractCompared to imaging in the visible and near-infrared regions below 900 nm, imaging in the second near-infrared window (NIR-II, 1000-1700 nm) is a promising method for deep-tissue high-resolution optical imaging in vivo mainly owing to the reduced scattering of photons traversing through biological tissues. Herein, semiconducting single-walled carbon nanotubes with large diameters were used for in vivo fluorescence imaging in the long-wavelength NIR region (1500-1700 nm, NIR-IIb). With this imaging agent, 3-4 μm wide capillary blood vessels at a depth of about 3 mm could be resolved. Meanwhile, the blood-flow speeds in multiple individual vessels could be mapped simultaneously. Furthermore, NIR-IIb tumor imaging of a live mouse was explored. NIR-IIb imaging can be generalized to a wide range of fluorophores emitting at up to 1700 nm for high-performance in vivo optical imaging. Semiconducting single-walled carbon nanotubes with large diameters were used for in vivo fluorescence imaging in the long-wavelength near-infrared region (1500-1700 nm). With this imaging agent, 3-4 μm wide capillary blood vessels at a depth of about 3 mm in living mice could be resolved, and the blood-flow speeds in multiple individual vessels were mapped simultaneously.
Persistent Identifierhttp://hdl.handle.net/10722/334441
ISSN
2023 Impact Factor: 16.1
2023 SCImago Journal Rankings: 5.300
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDiao, Shuo-
dc.contributor.authorBlackburn, Jeffrey L.-
dc.contributor.authorHong, Guosong-
dc.contributor.authorAntaris, Alexander L.-
dc.contributor.authorChang, Junlei-
dc.contributor.authorWu, Justin Z.-
dc.contributor.authorZhang, Bo-
dc.contributor.authorCheng, Kai-
dc.contributor.authorKuo, Calvin J.-
dc.contributor.authorDai, Hongjie-
dc.date.accessioned2023-10-20T06:48:10Z-
dc.date.available2023-10-20T06:48:10Z-
dc.date.issued2015-
dc.identifier.citationAngewandte Chemie - International Edition, 2015, v. 54, n. 49, p. 14758-14762-
dc.identifier.issn1433-7851-
dc.identifier.urihttp://hdl.handle.net/10722/334441-
dc.description.abstractCompared to imaging in the visible and near-infrared regions below 900 nm, imaging in the second near-infrared window (NIR-II, 1000-1700 nm) is a promising method for deep-tissue high-resolution optical imaging in vivo mainly owing to the reduced scattering of photons traversing through biological tissues. Herein, semiconducting single-walled carbon nanotubes with large diameters were used for in vivo fluorescence imaging in the long-wavelength NIR region (1500-1700 nm, NIR-IIb). With this imaging agent, 3-4 μm wide capillary blood vessels at a depth of about 3 mm could be resolved. Meanwhile, the blood-flow speeds in multiple individual vessels could be mapped simultaneously. Furthermore, NIR-IIb tumor imaging of a live mouse was explored. NIR-IIb imaging can be generalized to a wide range of fluorophores emitting at up to 1700 nm for high-performance in vivo optical imaging. Semiconducting single-walled carbon nanotubes with large diameters were used for in vivo fluorescence imaging in the long-wavelength near-infrared region (1500-1700 nm). With this imaging agent, 3-4 μm wide capillary blood vessels at a depth of about 3 mm in living mice could be resolved, and the blood-flow speeds in multiple individual vessels were mapped simultaneously.-
dc.languageeng-
dc.relation.ispartofAngewandte Chemie - International Edition-
dc.subjectcancer-
dc.subjectfluorescence-
dc.subjectimaging agents-
dc.subjectnanotechnology-
dc.subjectnear infrared-
dc.titleFluorescence imaging in Vivo at wavelengths beyond 1500 nm-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/anie.201507473-
dc.identifier.pmid26460151-
dc.identifier.scopuseid_2-s2.0-84983094796-
dc.identifier.volume54-
dc.identifier.issue49-
dc.identifier.spage14758-
dc.identifier.epage14762-
dc.identifier.eissn1521-3773-
dc.identifier.isiWOS:000367723400025-

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