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Article: 3D NIR-II Molecular Imaging Distinguishes Targeted Organs with High-Performance NIR-II Bioconjugates

Title3D NIR-II Molecular Imaging Distinguishes Targeted Organs with High-Performance NIR-II Bioconjugates
Authors
Keywords3D NIR-II molecular imaging
high-performance NIR-II bioconjugate
live ovary imaging
multicolor live molecular imaging
NIR-II confocal
Issue Date2018
Citation
Advanced Materials, 2018, v. 30, n. 13, article no. 1705799 How to Cite?
AbstractGreatly reduced scattering in the second near-infrared (NIR-II) region (1000–1700 nm) opens up many new exciting avenues of bioimaging research, yet NIR-II fluorescence imaging is mostly implemented by using nontargeted fluorophores or wide-field imaging setups, limiting the signal-to-background ratio and imaging penetration depth due to poor specific binding and out-of-focus signals. A newly developed high-performance NIR-II bioconjugate enables targeted imaging of a specific organ in the living body with high quality. Combined with a home-built NIR-II confocal set-up, the enhanced imaging technique allows 900 µm-deep 3D organ imaging without tissue clearing techniques. Bioconjugation of two hormones to nonoverlapping NIR-II fluorophores facilitates two-color imaging of different receptors, demonstrating unprecedented multicolor live molecular imaging across the NIR-II window. This deep tissue imaging of specific receptors in live animals allows development of noninvasive molecular imaging of multifarious models of normal and neoplastic organs in vivo, beyond the traditional visible to NIR-I range. The developed NIR-II fluorescence microscopy will become a powerful imaging technique for deep tissue imaging without any physical sectioning or clearing treatment of the tissue.
Persistent Identifierhttp://hdl.handle.net/10722/334526
ISSN
2023 Impact Factor: 27.4
2023 SCImago Journal Rankings: 9.191
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhu, Shoujun-
dc.contributor.authorHerraiz, Sonia-
dc.contributor.authorYue, Jingying-
dc.contributor.authorZhang, Mingxi-
dc.contributor.authorWan, Hao-
dc.contributor.authorYang, Qinglai-
dc.contributor.authorMa, Zhuoran-
dc.contributor.authorWang, Yan-
dc.contributor.authorHe, Jiahuan-
dc.contributor.authorAntaris, Alexander L.-
dc.contributor.authorZhong, Yeteng-
dc.contributor.authorDiao, Shuo-
dc.contributor.authorFeng, Yi-
dc.contributor.authorZhou, Ying-
dc.contributor.authorYu, Kuai-
dc.contributor.authorHong, Guosong-
dc.contributor.authorLiang, Yongye-
dc.contributor.authorHsueh, Aaron J.-
dc.contributor.authorDai, Hongjie-
dc.date.accessioned2023-10-20T06:48:46Z-
dc.date.available2023-10-20T06:48:46Z-
dc.date.issued2018-
dc.identifier.citationAdvanced Materials, 2018, v. 30, n. 13, article no. 1705799-
dc.identifier.issn0935-9648-
dc.identifier.urihttp://hdl.handle.net/10722/334526-
dc.description.abstractGreatly reduced scattering in the second near-infrared (NIR-II) region (1000–1700 nm) opens up many new exciting avenues of bioimaging research, yet NIR-II fluorescence imaging is mostly implemented by using nontargeted fluorophores or wide-field imaging setups, limiting the signal-to-background ratio and imaging penetration depth due to poor specific binding and out-of-focus signals. A newly developed high-performance NIR-II bioconjugate enables targeted imaging of a specific organ in the living body with high quality. Combined with a home-built NIR-II confocal set-up, the enhanced imaging technique allows 900 µm-deep 3D organ imaging without tissue clearing techniques. Bioconjugation of two hormones to nonoverlapping NIR-II fluorophores facilitates two-color imaging of different receptors, demonstrating unprecedented multicolor live molecular imaging across the NIR-II window. This deep tissue imaging of specific receptors in live animals allows development of noninvasive molecular imaging of multifarious models of normal and neoplastic organs in vivo, beyond the traditional visible to NIR-I range. The developed NIR-II fluorescence microscopy will become a powerful imaging technique for deep tissue imaging without any physical sectioning or clearing treatment of the tissue.-
dc.languageeng-
dc.relation.ispartofAdvanced Materials-
dc.subject3D NIR-II molecular imaging-
dc.subjecthigh-performance NIR-II bioconjugate-
dc.subjectlive ovary imaging-
dc.subjectmulticolor live molecular imaging-
dc.subjectNIR-II confocal-
dc.title3D NIR-II Molecular Imaging Distinguishes Targeted Organs with High-Performance NIR-II Bioconjugates-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/adma.201705799-
dc.identifier.pmid29446156-
dc.identifier.scopuseid_2-s2.0-85042008757-
dc.identifier.volume30-
dc.identifier.issue13-
dc.identifier.spagearticle no. 1705799-
dc.identifier.epagearticle no. 1705799-
dc.identifier.eissn1521-4095-
dc.identifier.isiWOS:000428793600012-

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