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Article: Microglia in Alzheimer's disease: A target for immunotherapy

TitleMicroglia in Alzheimer's disease: A target for immunotherapy
Authors
Wang, ShoutangColonna, Marco
KeywordsAlzheimer's disease
immunotherapy
microglia
neuroinflammation
phagocytosis
TREM2
Issue Date2019
Citation
Journal of Leukocyte Biology, 2019, v. 106, n. 1, p. 219-227 How to Cite?
DOI: http://dx.doi.org/10.1002/JLB.MR0818-319R
AbstractMicroglia are resident Mϕs of the CNS that play pleiotropic functions in brain development and homeostasis. Impaired microglial functions are thought to be involved in the onset and progression of various neurodevelopmental and neurodegenerative diseases. Thus, understanding microglia in these settings may indicate new approaches for therapeutic intervention. Here, we review recent evidence implicating microglia in Alzheimer's disease and discuss potential therapeutic strategies targeting microglia and their receptors in this disease.
Persistent Identifierhttp://hdl.handle.net/10722/334577
ISSN
0741-5400
2021 Impact Factor: 6.011
2020 SCImago Journal Rankings: 1.819
ISI Accession Number ID
WOS:000473095000020

 

DC FieldValueLanguage
dc.contributor.authorWang, Shoutang-
dc.contributor.authorColonna, Marco-
dc.date.accessioned2023-10-20T06:49:08Z-
dc.date.available2023-10-20T06:49:08Z-
dc.date.issued2019-
dc.identifier.citationJournal of Leukocyte Biology, 2019, v. 106, n. 1, p. 219-227-
dc.identifier.issn0741-5400-
dc.identifier.urihttp://hdl.handle.net/10722/334577-
dc.description.abstractMicroglia are resident Mϕs of the CNS that play pleiotropic functions in brain development and homeostasis. Impaired microglial functions are thought to be involved in the onset and progression of various neurodevelopmental and neurodegenerative diseases. Thus, understanding microglia in these settings may indicate new approaches for therapeutic intervention. Here, we review recent evidence implicating microglia in Alzheimer's disease and discuss potential therapeutic strategies targeting microglia and their receptors in this disease.-
dc.languageeng-
dc.relation.ispartofJournal of Leukocyte Biology-
dc.subjectAlzheimer's disease-
dc.subjectimmunotherapy-
dc.subjectmicroglia-
dc.subjectneuroinflammation-
dc.subjectphagocytosis-
dc.subjectTREM2-
dc.titleMicroglia in Alzheimer's disease: A target for immunotherapy-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/JLB.MR0818-319R-
dc.identifier.pmid30725482-
dc.identifier.scopuseid_2-s2.0-85061331096-
dc.identifier.volume106-
dc.identifier.issue1-
dc.identifier.spage219-
dc.identifier.epage227-
dc.identifier.eissn1938-3673-
dc.identifier.isiWOS:000473095000020-

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