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- Publisher Website: 10.1038/s42003-021-02886-5
- Scopus: eid_2-s2.0-85121042928
- PMID: 34887504
- WOS: WOS:000728600600007
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Article: Lyl-1 regulates primitive macrophages and microglia development
Title | Lyl-1 regulates primitive macrophages and microglia development |
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Authors | |
Issue Date | 2021 |
Citation | Communications Biology, 2021, v. 4, n. 1, article no. 1382 How to Cite? |
Abstract | During ontogeny, macrophage populations emerge in the Yolk Sac (YS) via two distinct progenitor waves, prior to hematopoietic stem cell development. Macrophage progenitors from the primitive/”early EMP” and transient-definitive/”late EMP” waves both contribute to various resident primitive macrophage populations in the developing embryonic organs. Identifying factors that modulates early stages of macrophage progenitor development may lead to a better understanding of defective function of specific resident macrophage subsets. Here we show that YS primitive macrophage progenitors express Lyl-1, a bHLH transcription factor related to SCL/Tal-1. Transcriptomic analysis of YS macrophage progenitors indicate that primitive macrophage progenitors present at embryonic day 9 are clearly distinct from those present at later stages. Disruption of Lyl-1 basic helix-loop-helix domain leads initially to an increased emergence of primitive macrophage progenitors, and later to their defective differentiation. These defects are associated with a disrupted expression of gene sets related to embryonic patterning and neurodevelopment. Lyl-1-deficiency also induce a reduced production of mature macrophages/microglia in the early brain, as well as a transient reduction of the microglia pool at midgestation and in the newborn. We thus identify Lyl-1 as a critical regulator of primitive macrophages and microglia development, which disruption may impair resident-macrophage function during organogenesis. |
Persistent Identifier | http://hdl.handle.net/10722/334797 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wang, Shoutang | - |
dc.contributor.author | Ren, Deshan | - |
dc.contributor.author | Arkoun, Brahim | - |
dc.contributor.author | Kaushik, Anna Lila | - |
dc.contributor.author | Matherat, Gabriel | - |
dc.contributor.author | Lécluse, Yann | - |
dc.contributor.author | Filipp, Dominik | - |
dc.contributor.author | Vainchenker, William | - |
dc.contributor.author | Raslova, Hana | - |
dc.contributor.author | Plo, Isabelle | - |
dc.contributor.author | Godin, Isabelle | - |
dc.date.accessioned | 2023-10-20T06:50:49Z | - |
dc.date.available | 2023-10-20T06:50:49Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Communications Biology, 2021, v. 4, n. 1, article no. 1382 | - |
dc.identifier.uri | http://hdl.handle.net/10722/334797 | - |
dc.description.abstract | During ontogeny, macrophage populations emerge in the Yolk Sac (YS) via two distinct progenitor waves, prior to hematopoietic stem cell development. Macrophage progenitors from the primitive/”early EMP” and transient-definitive/”late EMP” waves both contribute to various resident primitive macrophage populations in the developing embryonic organs. Identifying factors that modulates early stages of macrophage progenitor development may lead to a better understanding of defective function of specific resident macrophage subsets. Here we show that YS primitive macrophage progenitors express Lyl-1, a bHLH transcription factor related to SCL/Tal-1. Transcriptomic analysis of YS macrophage progenitors indicate that primitive macrophage progenitors present at embryonic day 9 are clearly distinct from those present at later stages. Disruption of Lyl-1 basic helix-loop-helix domain leads initially to an increased emergence of primitive macrophage progenitors, and later to their defective differentiation. These defects are associated with a disrupted expression of gene sets related to embryonic patterning and neurodevelopment. Lyl-1-deficiency also induce a reduced production of mature macrophages/microglia in the early brain, as well as a transient reduction of the microglia pool at midgestation and in the newborn. We thus identify Lyl-1 as a critical regulator of primitive macrophages and microglia development, which disruption may impair resident-macrophage function during organogenesis. | - |
dc.language | eng | - |
dc.relation.ispartof | Communications Biology | - |
dc.title | Lyl-1 regulates primitive macrophages and microglia development | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1038/s42003-021-02886-5 | - |
dc.identifier.pmid | 34887504 | - |
dc.identifier.scopus | eid_2-s2.0-85121042928 | - |
dc.identifier.volume | 4 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | article no. 1382 | - |
dc.identifier.epage | article no. 1382 | - |
dc.identifier.eissn | 2399-3642 | - |
dc.identifier.isi | WOS:000728600600007 | - |