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Article: Phospholipid-dextran with a single coupling point: A useful amphiphile for functionalization of nanomaterials

TitlePhospholipid-dextran with a single coupling point: A useful amphiphile for functionalization of nanomaterials
Authors
Issue Date2009
Citation
Journal of the American Chemical Society, 2009, v. 131, n. 1, p. 289-296 How to Cite?
AbstractNanomaterials hold much promise for biological applications, but they require appropriate functionalization to provide biocompatibility in biological environments. For noncovalent functionalization with biocompatible polymers, the polymer must also remain attached to the nanomaterial after removal of its excess to mimic the high-dilution conditions of administration in vivo. Reported here are the synthesis and utilization of singly substituted conjugates of dextran and a phospholipid (dextran-DSPE) as stable coatings for nanomaterials. Suspensions of single-walled carbon nanotubes were found not only to be stable to phosphate buffered saline (PBS), serum, and a variety of pH's after excess polymer removal, but also to provide brighter photoluminescence than carbon nanotubes suspended by poly(ethylene glycol)-DSPE. In addition, both gold nanoparticles (AuNPs) and gold nanorods (AuNRs) were found to maintain their dispersion and characteristic optical absorbance after transfer into dextran-DSPE and were obtained in much better yield than similar suspensions with PEG-phospholipid and commonly used thiol-PEG. These suspensions were also stable to PBS, serum, and a variety of pH's after removal of excess polymer. dextran-DSPE thus shows great promise as a general surfactant material for the functionalization of a variety of nanomaterials, which could facilitate future biological applications. © 2009 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/334934
ISSN
2023 Impact Factor: 14.4
2023 SCImago Journal Rankings: 5.489
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGoodwin, Andrew P.-
dc.contributor.authorTabakman, Scott M.-
dc.contributor.authorWelsher, Kevin-
dc.contributor.authorSherlock, Sarah P.-
dc.contributor.authorPrencipe, Giuseppe-
dc.contributor.authorDai, Hongjie-
dc.date.accessioned2023-10-20T06:51:50Z-
dc.date.available2023-10-20T06:51:50Z-
dc.date.issued2009-
dc.identifier.citationJournal of the American Chemical Society, 2009, v. 131, n. 1, p. 289-296-
dc.identifier.issn0002-7863-
dc.identifier.urihttp://hdl.handle.net/10722/334934-
dc.description.abstractNanomaterials hold much promise for biological applications, but they require appropriate functionalization to provide biocompatibility in biological environments. For noncovalent functionalization with biocompatible polymers, the polymer must also remain attached to the nanomaterial after removal of its excess to mimic the high-dilution conditions of administration in vivo. Reported here are the synthesis and utilization of singly substituted conjugates of dextran and a phospholipid (dextran-DSPE) as stable coatings for nanomaterials. Suspensions of single-walled carbon nanotubes were found not only to be stable to phosphate buffered saline (PBS), serum, and a variety of pH's after excess polymer removal, but also to provide brighter photoluminescence than carbon nanotubes suspended by poly(ethylene glycol)-DSPE. In addition, both gold nanoparticles (AuNPs) and gold nanorods (AuNRs) were found to maintain their dispersion and characteristic optical absorbance after transfer into dextran-DSPE and were obtained in much better yield than similar suspensions with PEG-phospholipid and commonly used thiol-PEG. These suspensions were also stable to PBS, serum, and a variety of pH's after removal of excess polymer. dextran-DSPE thus shows great promise as a general surfactant material for the functionalization of a variety of nanomaterials, which could facilitate future biological applications. © 2009 American Chemical Society.-
dc.languageeng-
dc.relation.ispartofJournal of the American Chemical Society-
dc.titlePhospholipid-dextran with a single coupling point: A useful amphiphile for functionalization of nanomaterials-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/ja807307e-
dc.identifier.pmid19061329-
dc.identifier.scopuseid_2-s2.0-62649084732-
dc.identifier.volume131-
dc.identifier.issue1-
dc.identifier.spage289-
dc.identifier.epage296-
dc.identifier.isiWOS:000262483100060-

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