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Article: Donor Engineering for NIR-II Molecular Fluorophores with Enhanced Fluorescent Performance

TitleDonor Engineering for NIR-II Molecular Fluorophores with Enhanced Fluorescent Performance
Authors
Issue Date2018
Citation
Journal of the American Chemical Society, 2018, v. 140, n. 5, p. 1715-1724 How to Cite?
AbstractOrganic fluorophores have been widely used for biological imaging in the visible and the first near-infrared windows. However, their application in the second near-infrared window (NIR-II, 1000-1700 nm) is still limited mainly due to low fluorescence quantum yields (QYs). Here, we explore molecular engineering on the donor unit to develop high performance NIR-II fluorophores. The fluorophores are constructed by a shielding unit-donor(s)-acceptor-donor(s)-shielding unit structure. Thiophene is introduced as the second donor connected to the shielding unit, which can increase the conjugation length and red-shift the fluorescence emission. Alkyl thiophene is employed as the first donor connected to the acceptor unit. The bulky and hydrophobic alkyl thiophene donor affords larger distortion of the conjugated backbone and fewer interactions with water molecules compared to other donor units studied before. The molecular fluorophore IR-FTAP with octyl thiophene as the first donor and thiophene as the second donor exhibits fluorescence emission peaked at 1048 nm with a QY of 5.3% in aqueous solutions, one of the highest for molecular NIR-II fluorophore reported so far. Superior temporal and spatial resolutions have been demonstrated with IR-FTAP fluorophore for NIR-II imaging of the blood vessels of a mouse hindlimb.
Persistent Identifierhttp://hdl.handle.net/10722/334949
ISSN
2023 Impact Factor: 14.4
2023 SCImago Journal Rankings: 5.489
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYang, Qinglai-
dc.contributor.authorHu, Zhubin-
dc.contributor.authorZhu, Shoujun-
dc.contributor.authorMa, Rui-
dc.contributor.authorMa, Huilong-
dc.contributor.authorMa, Zhuoran-
dc.contributor.authorWan, Hao-
dc.contributor.authorZhu, Tong-
dc.contributor.authorJiang, Zhengyan-
dc.contributor.authorLiu, Weiqiang-
dc.contributor.authorJiao, Liying-
dc.contributor.authorSun, Haitao-
dc.contributor.authorLiang, Yongye-
dc.contributor.authorDai, Hongjie-
dc.date.accessioned2023-10-20T06:51:56Z-
dc.date.available2023-10-20T06:51:56Z-
dc.date.issued2018-
dc.identifier.citationJournal of the American Chemical Society, 2018, v. 140, n. 5, p. 1715-1724-
dc.identifier.issn0002-7863-
dc.identifier.urihttp://hdl.handle.net/10722/334949-
dc.description.abstractOrganic fluorophores have been widely used for biological imaging in the visible and the first near-infrared windows. However, their application in the second near-infrared window (NIR-II, 1000-1700 nm) is still limited mainly due to low fluorescence quantum yields (QYs). Here, we explore molecular engineering on the donor unit to develop high performance NIR-II fluorophores. The fluorophores are constructed by a shielding unit-donor(s)-acceptor-donor(s)-shielding unit structure. Thiophene is introduced as the second donor connected to the shielding unit, which can increase the conjugation length and red-shift the fluorescence emission. Alkyl thiophene is employed as the first donor connected to the acceptor unit. The bulky and hydrophobic alkyl thiophene donor affords larger distortion of the conjugated backbone and fewer interactions with water molecules compared to other donor units studied before. The molecular fluorophore IR-FTAP with octyl thiophene as the first donor and thiophene as the second donor exhibits fluorescence emission peaked at 1048 nm with a QY of 5.3% in aqueous solutions, one of the highest for molecular NIR-II fluorophore reported so far. Superior temporal and spatial resolutions have been demonstrated with IR-FTAP fluorophore for NIR-II imaging of the blood vessels of a mouse hindlimb.-
dc.languageeng-
dc.relation.ispartofJournal of the American Chemical Society-
dc.titleDonor Engineering for NIR-II Molecular Fluorophores with Enhanced Fluorescent Performance-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/jacs.7b10334-
dc.identifier.pmid29337545-
dc.identifier.scopuseid_2-s2.0-85041932068-
dc.identifier.volume140-
dc.identifier.issue5-
dc.identifier.spage1715-
dc.identifier.epage1724-
dc.identifier.eissn1520-5126-
dc.identifier.isiWOS:000424851500024-

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