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- Publisher Website: 10.1111/adb.12338
- Scopus: eid_2-s2.0-84953311164
- PMID: 26732520
- WOS: WOS:000400600700016
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Article: Activation of the ventral and dorsal striatum during cue reactivity in Internet gaming disorder
Title | Activation of the ventral and dorsal striatum during cue reactivity in Internet gaming disorder |
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Authors | |
Keywords | cue-reactivity dorsal striatum fMRI Internet gaming disorder ventral striatum |
Issue Date | 2017 |
Citation | Addiction Biology, 2017, v. 22, n. 3, p. 791-801 How to Cite? |
Abstract | Studies conducted in drug addiction suggest a transition in processing of drug-related cues from the ventral to the dorsal component of the striatum. However, this process has not been studied in a behavioral addiction. Assessment of this process in a non-drug addiction can provide insight into the pathophysiology of both substance and behavioral addictions. Thirty-nine male Internet gaming disorder (IGD) subjects and 23 male matched healthy controls (HCs) participated in functional magnetic resonance imaging during performance of a cue-reactivity task involving alternating presentation of Internet gaming-related stimuli (game cues) and general Internet surfing-related stimuli (control cues). Cue-induced neural activations in the ventral and dorsal striatum (DS) were compared between IGD and HC participants. Associations between cue-reactivity within these regions and cue-induced craving and severity and duration of IGD were also explored. IGD participants exhibited higher cue-induced activations within both the ventral and DS when compared with HCs. Within the IGD group, activity within the left ventral striatum (VS) was correlated negatively with cue-induced craving; positive associations were found between activations within the DS (right putamen, pallidum and left caudate) and duration of IGD. Cue-induced activity within the left putamen was negatively associated with right VS volumes among IGD participants. Consistent with studies in substance addictions, our results suggest that a transition from ventral to dorsal striatal processing may occur among individuals with IGD, a condition without the impact of substance intake. |
Persistent Identifier | http://hdl.handle.net/10722/335260 |
ISSN | 2021 Impact Factor: 4.093 2020 SCImago Journal Rankings: 1.445 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Liu, Lu | - |
dc.contributor.author | Yip, Sarah W. | - |
dc.contributor.author | Zhang, Jin Tao | - |
dc.contributor.author | Wang, Ling Jiao | - |
dc.contributor.author | Shen, Zi Jiao | - |
dc.contributor.author | Liu, Ben | - |
dc.contributor.author | Ma, Shan Shan | - |
dc.contributor.author | Yao, Yuan Wei | - |
dc.contributor.author | Fang, Xiao Yi | - |
dc.date.accessioned | 2023-11-17T08:24:23Z | - |
dc.date.available | 2023-11-17T08:24:23Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Addiction Biology, 2017, v. 22, n. 3, p. 791-801 | - |
dc.identifier.issn | 1355-6215 | - |
dc.identifier.uri | http://hdl.handle.net/10722/335260 | - |
dc.description.abstract | Studies conducted in drug addiction suggest a transition in processing of drug-related cues from the ventral to the dorsal component of the striatum. However, this process has not been studied in a behavioral addiction. Assessment of this process in a non-drug addiction can provide insight into the pathophysiology of both substance and behavioral addictions. Thirty-nine male Internet gaming disorder (IGD) subjects and 23 male matched healthy controls (HCs) participated in functional magnetic resonance imaging during performance of a cue-reactivity task involving alternating presentation of Internet gaming-related stimuli (game cues) and general Internet surfing-related stimuli (control cues). Cue-induced neural activations in the ventral and dorsal striatum (DS) were compared between IGD and HC participants. Associations between cue-reactivity within these regions and cue-induced craving and severity and duration of IGD were also explored. IGD participants exhibited higher cue-induced activations within both the ventral and DS when compared with HCs. Within the IGD group, activity within the left ventral striatum (VS) was correlated negatively with cue-induced craving; positive associations were found between activations within the DS (right putamen, pallidum and left caudate) and duration of IGD. Cue-induced activity within the left putamen was negatively associated with right VS volumes among IGD participants. Consistent with studies in substance addictions, our results suggest that a transition from ventral to dorsal striatal processing may occur among individuals with IGD, a condition without the impact of substance intake. | - |
dc.language | eng | - |
dc.relation.ispartof | Addiction Biology | - |
dc.subject | cue-reactivity | - |
dc.subject | dorsal striatum | - |
dc.subject | fMRI | - |
dc.subject | Internet gaming disorder | - |
dc.subject | ventral striatum | - |
dc.title | Activation of the ventral and dorsal striatum during cue reactivity in Internet gaming disorder | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/adb.12338 | - |
dc.identifier.pmid | 26732520 | - |
dc.identifier.scopus | eid_2-s2.0-84953311164 | - |
dc.identifier.volume | 22 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 791 | - |
dc.identifier.epage | 801 | - |
dc.identifier.eissn | 1369-1600 | - |
dc.identifier.isi | WOS:000400600700016 | - |