File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1111/adb.12474
- Scopus: eid_2-s2.0-85006166307
- PMID: 27894158
- WOS: WOS:000425208700030
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Craving behavioral intervention for internet gaming disorder: remediation of functional connectivity of the ventral striatum
Title | Craving behavioral intervention for internet gaming disorder: remediation of functional connectivity of the ventral striatum |
---|---|
Authors | |
Keywords | attentional bias craving behavioral intervention inferior parietal lobule Internet gaming disorder resting-state functional connectivity ventral striatum |
Issue Date | 2018 |
Citation | Addiction Biology, 2018, v. 23, n. 1, p. 337-346 How to Cite? |
Abstract | Psychobehavioral intervention is an effective treatment of Internet addiction, including Internet gaming disorder (IGD). However, the neural mechanisms underlying its efficacy remain unclear. Cortical-ventral striatum (VS) circuitry is a common target of psychobehavioral interventions in drug addiction, and cortical-VS dysfunction has been reported in IGD; hence, the primary aim of the study was to investigate how the VS circuitry responds to psychobehavioral interventions in IGD. In a cross-sectional study, we examined resting-state functional connectivity of the VS in 74 IGD subjects (IGDs) and 41 healthy controls (HCs). In a follow-up craving behavioral intervention (CBI) study, of the 74 IGD subjects, 20 IGD subjects received CBI (CBI+) and 16 IGD subjects did not (CBI−). All participants were scanned twice with similar time interval to assess the effects of CBI. IGD subjects showed greater resting-state functional connectivity of the VS to left inferior parietal lobule (lIPL), right inferior frontal gyrus and left middle frontal gyrus, in positive association with the severity of IGD. Moreover, compared with CBI−, CBI+ showed significantly greater decrease in VS-lIPL connectivity, along with amelioration in addiction severity following the intervention. These findings demonstrated that functional connectivity between VS and lIPL, each presumably mediating gaming craving and attentional bias, may be a potential biomarker of the efficacy of psychobehavioral intervention. These results also suggested that non-invasive techniques such as transcranial magnetic or direct current stimulation targeting the VS-IPL circuitry may be used in the treatment of Internet gaming disorders. |
Persistent Identifier | http://hdl.handle.net/10722/335280 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 1.154 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhang, Jin Tao | - |
dc.contributor.author | Ma, Shan Shan | - |
dc.contributor.author | Li, Chiang Shan R. | - |
dc.contributor.author | Liu, Lu | - |
dc.contributor.author | Xia, Cui Cui | - |
dc.contributor.author | Lan, Jing | - |
dc.contributor.author | Wang, Ling Jiao | - |
dc.contributor.author | Liu, Ben | - |
dc.contributor.author | Yao, Yuan Wei | - |
dc.contributor.author | Fang, Xiao Yi | - |
dc.date.accessioned | 2023-11-17T08:24:33Z | - |
dc.date.available | 2023-11-17T08:24:33Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Addiction Biology, 2018, v. 23, n. 1, p. 337-346 | - |
dc.identifier.issn | 1355-6215 | - |
dc.identifier.uri | http://hdl.handle.net/10722/335280 | - |
dc.description.abstract | Psychobehavioral intervention is an effective treatment of Internet addiction, including Internet gaming disorder (IGD). However, the neural mechanisms underlying its efficacy remain unclear. Cortical-ventral striatum (VS) circuitry is a common target of psychobehavioral interventions in drug addiction, and cortical-VS dysfunction has been reported in IGD; hence, the primary aim of the study was to investigate how the VS circuitry responds to psychobehavioral interventions in IGD. In a cross-sectional study, we examined resting-state functional connectivity of the VS in 74 IGD subjects (IGDs) and 41 healthy controls (HCs). In a follow-up craving behavioral intervention (CBI) study, of the 74 IGD subjects, 20 IGD subjects received CBI (CBI+) and 16 IGD subjects did not (CBI−). All participants were scanned twice with similar time interval to assess the effects of CBI. IGD subjects showed greater resting-state functional connectivity of the VS to left inferior parietal lobule (lIPL), right inferior frontal gyrus and left middle frontal gyrus, in positive association with the severity of IGD. Moreover, compared with CBI−, CBI+ showed significantly greater decrease in VS-lIPL connectivity, along with amelioration in addiction severity following the intervention. These findings demonstrated that functional connectivity between VS and lIPL, each presumably mediating gaming craving and attentional bias, may be a potential biomarker of the efficacy of psychobehavioral intervention. These results also suggested that non-invasive techniques such as transcranial magnetic or direct current stimulation targeting the VS-IPL circuitry may be used in the treatment of Internet gaming disorders. | - |
dc.language | eng | - |
dc.relation.ispartof | Addiction Biology | - |
dc.subject | attentional bias | - |
dc.subject | craving behavioral intervention | - |
dc.subject | inferior parietal lobule | - |
dc.subject | Internet gaming disorder | - |
dc.subject | resting-state functional connectivity | - |
dc.subject | ventral striatum | - |
dc.title | Craving behavioral intervention for internet gaming disorder: remediation of functional connectivity of the ventral striatum | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/adb.12474 | - |
dc.identifier.pmid | 27894158 | - |
dc.identifier.scopus | eid_2-s2.0-85006166307 | - |
dc.identifier.volume | 23 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 337 | - |
dc.identifier.epage | 346 | - |
dc.identifier.eissn | 1369-1600 | - |
dc.identifier.isi | WOS:000425208700030 | - |