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Article: Plasmonic ZnO nanorods/Au substrates for protein microarrays with high sensitivity and broad dynamic range

TitlePlasmonic ZnO nanorods/Au substrates for protein microarrays with high sensitivity and broad dynamic range
Authors
KeywordsBiomarker detection
Fluorescence enhancement
Immunoassay
Plasmonic
Protein microarray
ZnO nanorods
Issue Date2016
Citation
Sensors and Actuators, B: Chemical, 2016, v. 228, p. 231-236 How to Cite?
AbstractMicroarrays require high sensitivity and a broad dynamic range for high-throughput diagnostics and proteomic analysis. We present the fabrication of novel plasmonic protein microarrays using nanostructured ZnO-Nanorods (ZnO-NRs) on 50 nm Au film that exhibits an enhancement of fluorescence up to 200-fold. The as-prepared plasmonic protein microarrays were used for the detection of the carcinoembryonic antigen (CEA) cancer biomarker. The plasmonic enhancement resulted in a detection limit of 27 pg mL-1 in 0.01 M PBS and a dynamic range of 100 pg mL-1 to 100 μg mL-1. The ZnO-NRs/Au substrates can be mass-manufactured, which is highly promising for the development of low cost, sensitive, and high-throughput protein assay platform for applications in clinical diagnosis.
Persistent Identifierhttp://hdl.handle.net/10722/335787
ISSN
2023 Impact Factor: 8.0
2023 SCImago Journal Rankings: 1.475
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, Chang-
dc.contributor.authorMeng, Fanling-
dc.contributor.authorZheng, Weitao-
dc.contributor.authorXue, Tianyu-
dc.contributor.authorJin, Zhao-
dc.contributor.authorWang, Zhenxin-
dc.contributor.authorCui, Xiaoqiang-
dc.date.accessioned2023-12-28T08:48:45Z-
dc.date.available2023-12-28T08:48:45Z-
dc.date.issued2016-
dc.identifier.citationSensors and Actuators, B: Chemical, 2016, v. 228, p. 231-236-
dc.identifier.issn0925-4005-
dc.identifier.urihttp://hdl.handle.net/10722/335787-
dc.description.abstractMicroarrays require high sensitivity and a broad dynamic range for high-throughput diagnostics and proteomic analysis. We present the fabrication of novel plasmonic protein microarrays using nanostructured ZnO-Nanorods (ZnO-NRs) on 50 nm Au film that exhibits an enhancement of fluorescence up to 200-fold. The as-prepared plasmonic protein microarrays were used for the detection of the carcinoembryonic antigen (CEA) cancer biomarker. The plasmonic enhancement resulted in a detection limit of 27 pg mL-1 in 0.01 M PBS and a dynamic range of 100 pg mL-1 to 100 μg mL-1. The ZnO-NRs/Au substrates can be mass-manufactured, which is highly promising for the development of low cost, sensitive, and high-throughput protein assay platform for applications in clinical diagnosis.-
dc.languageeng-
dc.relation.ispartofSensors and Actuators, B: Chemical-
dc.subjectBiomarker detection-
dc.subjectFluorescence enhancement-
dc.subjectImmunoassay-
dc.subjectPlasmonic-
dc.subjectProtein microarray-
dc.subjectZnO nanorods-
dc.titlePlasmonic ZnO nanorods/Au substrates for protein microarrays with high sensitivity and broad dynamic range-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.snb.2016.01.019-
dc.identifier.scopuseid_2-s2.0-84955516252-
dc.identifier.volume228-
dc.identifier.spage231-
dc.identifier.epage236-
dc.identifier.isiWOS:000371027900032-

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