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- Publisher Website: 10.1016/j.phrs.2017.09.025
- Scopus: eid_2-s2.0-85031124016
- PMID: 29017932
- WOS: WOS:000435626500039
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Article: Tanshinone I prevents atorvastatin-induced cerebral hemorrhage in zebrafish and stabilizes endothelial cell–cell adhesion by inhibiting VE-cadherin internalization and actin-myosin contractility
Title | Tanshinone I prevents atorvastatin-induced cerebral hemorrhage in zebrafish and stabilizes endothelial cell–cell adhesion by inhibiting VE-cadherin internalization and actin-myosin contractility |
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Authors | |
Keywords | Endothelial cell adhesion Hemorrhagic stroke HUVECs Tanshinone I Vascular integrity Zebrafish |
Issue Date | 2018 |
Citation | Pharmacological Research, 2018, v. 128, p. 389-398 How to Cite? |
Abstract | Defects in vascular integrity in cerebrovasculature lead to serious pathologies including hemorrhagic stroke. The stability of cell adhesion junctions and actin-myosin contractile machinery are two major determinants for the integrity of endothelial monolayer. Here we have evaluated the protective effects of tanshinone I (Tan I), a lipophilic compound presents in Salvia miltiorrhiza, against atorvastatin-induced cerebral hemorrhage in zebrafish in vivo, and further dissected the molecular mechanisms in HUVECs. We demonstrated that Tan I protected endothelial integrity by stabilizing cell–cell adhesion junctions via the inhibition of Src-mediated VE-cadherin internalization and subsequent junction-linked actin cytoskeleton depolymerization. In addition, Tan I inhibited ROCK-associated endothelial contractile machinery by dephosphorylating cofilin and MYPT1. These findings identified Tan I as an endothelial stabilizing agent and suggested Tan I as a potential treatment for vascular leakage in hemorrhagic stroke. |
Persistent Identifier | http://hdl.handle.net/10722/335812 |
ISSN | 2021 Impact Factor: 10.334 2020 SCImago Journal Rankings: 1.850 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Huang, Bin | - |
dc.contributor.author | Zhou, Zhong Yan | - |
dc.contributor.author | Li, Shang | - |
dc.contributor.author | Huang, Xiao Hui | - |
dc.contributor.author | Tang, Jing Yi | - |
dc.contributor.author | Hoi, Maggie Pui Man | - |
dc.contributor.author | Lee, Simon Ming Yuen | - |
dc.date.accessioned | 2023-12-28T08:48:56Z | - |
dc.date.available | 2023-12-28T08:48:56Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Pharmacological Research, 2018, v. 128, p. 389-398 | - |
dc.identifier.issn | 1043-6618 | - |
dc.identifier.uri | http://hdl.handle.net/10722/335812 | - |
dc.description.abstract | Defects in vascular integrity in cerebrovasculature lead to serious pathologies including hemorrhagic stroke. The stability of cell adhesion junctions and actin-myosin contractile machinery are two major determinants for the integrity of endothelial monolayer. Here we have evaluated the protective effects of tanshinone I (Tan I), a lipophilic compound presents in Salvia miltiorrhiza, against atorvastatin-induced cerebral hemorrhage in zebrafish in vivo, and further dissected the molecular mechanisms in HUVECs. We demonstrated that Tan I protected endothelial integrity by stabilizing cell–cell adhesion junctions via the inhibition of Src-mediated VE-cadherin internalization and subsequent junction-linked actin cytoskeleton depolymerization. In addition, Tan I inhibited ROCK-associated endothelial contractile machinery by dephosphorylating cofilin and MYPT1. These findings identified Tan I as an endothelial stabilizing agent and suggested Tan I as a potential treatment for vascular leakage in hemorrhagic stroke. | - |
dc.language | eng | - |
dc.relation.ispartof | Pharmacological Research | - |
dc.subject | Endothelial cell adhesion | - |
dc.subject | Hemorrhagic stroke | - |
dc.subject | HUVECs | - |
dc.subject | Tanshinone I | - |
dc.subject | Vascular integrity | - |
dc.subject | Zebrafish | - |
dc.title | Tanshinone I prevents atorvastatin-induced cerebral hemorrhage in zebrafish and stabilizes endothelial cell–cell adhesion by inhibiting VE-cadherin internalization and actin-myosin contractility | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.phrs.2017.09.025 | - |
dc.identifier.pmid | 29017932 | - |
dc.identifier.scopus | eid_2-s2.0-85031124016 | - |
dc.identifier.volume | 128 | - |
dc.identifier.spage | 389 | - |
dc.identifier.epage | 398 | - |
dc.identifier.eissn | 1096-1186 | - |
dc.identifier.isi | WOS:000435626500039 | - |