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- Publisher Website: 10.1093/jacamr/dlac036
- Scopus: eid_2-s2.0-85135927044
- WOS: WOS:000784327800004
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Article: Risk factors for carriage of antimicrobial-resistant bacteria in community dwelling-children in the Asia-Pacific region: a systematic review and meta-analysis
Title | Risk factors for carriage of antimicrobial-resistant bacteria in community dwelling-children in the Asia-Pacific region: a systematic review and meta-analysis |
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Authors | |
Issue Date | 2022 |
Citation | JAC-Antimicrobial Resistance, 2022, v. 4, n. 2, article no. dlac036 How to Cite? |
Abstract | Background: Antimicrobial resistance is an increasingly important issue in public health as antibiotics are overused. Resistance to antimicrobial agents can pose significant challenges to infection treatment. Objectives: To evaluate risk factors associated with carriage of antimicrobial-resistant (AMR) bacteria in children in the Asia-Pacific region to consolidate evidence for future implementation of antibiotic prescribing practice. Methods: Three electronic databases - PubMed, EMBASE and Cochrane Library - were searched. Observational studies that investigated the risk factors for carriage of MRSA, penicillin-resistant Streptococcus pneumoniae, ESBL-producing Escherichia coli and Klebsiella pneumoniae among the paediatric population in community settings in the Asia-Pacific region were considered eligible. Summary statistics from the identified studies were pooled using meta-analyses. Results: From the 4145 search results, 25 papers were included in this review. Sixteen papers were included in the meta-analysis based on reported risk factors. Young age of 2-6months compared with children aged 7-60months (OR 2.74, 95% CI: 1.75-4.29), antibiotic use within the past 3months (OR 2.65, 95% CI: 1.70-4.12), daycare attendance (OR 1.49, 95% CI: 1.17-1.91) and hospital admission within the past 3months (OR 3.43, 95% CI: 2.13-5.51) were found to be significant risk factors for AMR bacterial carriage, whilst breastfeeding (OR 0.69, 95% CI: 0.60-0.81) and concurrent colonization of S. pneumoniae (OR 0.59, 95% CI: 0.38-0.91) are protective factors. Conclusions: The findings support that there are a number of significant risk factors associated with carriage of AMR bacteria in the Asia-Pacific paediatric population. To combat antimicrobial resistance in the future, these risk factors should be considered, and measures taken to mitigate associated carriage. |
Persistent Identifier | http://hdl.handle.net/10722/336330 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chan, Yi Qi | - |
dc.contributor.author | Chen, Kailin | - |
dc.contributor.author | Chua, Gilbert T. | - |
dc.contributor.author | Wu, Peng | - |
dc.contributor.author | Tung, Keith T.S. | - |
dc.contributor.author | Tsang, Hing Wai | - |
dc.contributor.author | Lung, David | - |
dc.contributor.author | Ip, Patrick | - |
dc.contributor.author | Chui, Celine S.L. | - |
dc.date.accessioned | 2024-01-15T08:25:39Z | - |
dc.date.available | 2024-01-15T08:25:39Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | JAC-Antimicrobial Resistance, 2022, v. 4, n. 2, article no. dlac036 | - |
dc.identifier.uri | http://hdl.handle.net/10722/336330 | - |
dc.description.abstract | Background: Antimicrobial resistance is an increasingly important issue in public health as antibiotics are overused. Resistance to antimicrobial agents can pose significant challenges to infection treatment. Objectives: To evaluate risk factors associated with carriage of antimicrobial-resistant (AMR) bacteria in children in the Asia-Pacific region to consolidate evidence for future implementation of antibiotic prescribing practice. Methods: Three electronic databases - PubMed, EMBASE and Cochrane Library - were searched. Observational studies that investigated the risk factors for carriage of MRSA, penicillin-resistant Streptococcus pneumoniae, ESBL-producing Escherichia coli and Klebsiella pneumoniae among the paediatric population in community settings in the Asia-Pacific region were considered eligible. Summary statistics from the identified studies were pooled using meta-analyses. Results: From the 4145 search results, 25 papers were included in this review. Sixteen papers were included in the meta-analysis based on reported risk factors. Young age of 2-6months compared with children aged 7-60months (OR 2.74, 95% CI: 1.75-4.29), antibiotic use within the past 3months (OR 2.65, 95% CI: 1.70-4.12), daycare attendance (OR 1.49, 95% CI: 1.17-1.91) and hospital admission within the past 3months (OR 3.43, 95% CI: 2.13-5.51) were found to be significant risk factors for AMR bacterial carriage, whilst breastfeeding (OR 0.69, 95% CI: 0.60-0.81) and concurrent colonization of S. pneumoniae (OR 0.59, 95% CI: 0.38-0.91) are protective factors. Conclusions: The findings support that there are a number of significant risk factors associated with carriage of AMR bacteria in the Asia-Pacific paediatric population. To combat antimicrobial resistance in the future, these risk factors should be considered, and measures taken to mitigate associated carriage. | - |
dc.language | eng | - |
dc.relation.ispartof | JAC-Antimicrobial Resistance | - |
dc.title | Risk factors for carriage of antimicrobial-resistant bacteria in community dwelling-children in the Asia-Pacific region: a systematic review and meta-analysis | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1093/jacamr/dlac036 | - |
dc.identifier.scopus | eid_2-s2.0-85135927044 | - |
dc.identifier.volume | 4 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | article no. dlac036 | - |
dc.identifier.epage | article no. dlac036 | - |
dc.identifier.eissn | 2632-1823 | - |
dc.identifier.isi | WOS:000784327800004 | - |