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- Publisher Website: 10.1007/s40496-018-0199-6
- Scopus: eid_2-s2.0-85075514319
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Article: Oral Polymorphonuclear Neutrophil Contributes to Oral Health
Title | Oral Polymorphonuclear Neutrophil Contributes to Oral Health |
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Authors | |
Keywords | Apoptosis Degranulation Neutrophils Oral health Reactive oxygen species |
Issue Date | 2018 |
Citation | Current Oral Health Reports, 2018, v. 5, n. 4, p. 211-220 How to Cite? |
Abstract | Purpose of Review: Oral health is maintained in a dynamic equilibrium between the host immunity and the oral microbiome. Oral polymorphonuclear neutrophils (oPMNs) are important innate immune cells in the oral cavity. Recent Findings: The oPMNs play a co-controlling part in the maintenance of oral equilibrium. In human saliva, the oPMNs integrity is preserved, and their function remains unaffected. In general, oPMNs are in a higher state of baseline activation compared to peripheral PMNs. However, in periodontitis, the oPMNs’ activation state can result in excessive release of damaging molecules in the extracellular environment. Summary: The presence of oPMNs may unwittingly negatively impact the integrity of the oral tissues. While most of the oPMN functions occur intracellularly, release of their potent active mediators into the extracellular environment may jeopardize oral homeostasis and its integrity. The dual nature of oPMNs, both beneficial and detrimental, remains a challenging and understudied topic. |
Persistent Identifier | http://hdl.handle.net/10722/336771 |
DC Field | Value | Language |
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dc.contributor.author | Rijkschroeff, Patrick | - |
dc.contributor.author | Loos, Bruno G. | - |
dc.contributor.author | Nicu, Elena A. | - |
dc.date.accessioned | 2024-02-29T06:56:26Z | - |
dc.date.available | 2024-02-29T06:56:26Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Current Oral Health Reports, 2018, v. 5, n. 4, p. 211-220 | - |
dc.identifier.uri | http://hdl.handle.net/10722/336771 | - |
dc.description.abstract | Purpose of Review: Oral health is maintained in a dynamic equilibrium between the host immunity and the oral microbiome. Oral polymorphonuclear neutrophils (oPMNs) are important innate immune cells in the oral cavity. Recent Findings: The oPMNs play a co-controlling part in the maintenance of oral equilibrium. In human saliva, the oPMNs integrity is preserved, and their function remains unaffected. In general, oPMNs are in a higher state of baseline activation compared to peripheral PMNs. However, in periodontitis, the oPMNs’ activation state can result in excessive release of damaging molecules in the extracellular environment. Summary: The presence of oPMNs may unwittingly negatively impact the integrity of the oral tissues. While most of the oPMN functions occur intracellularly, release of their potent active mediators into the extracellular environment may jeopardize oral homeostasis and its integrity. The dual nature of oPMNs, both beneficial and detrimental, remains a challenging and understudied topic. | - |
dc.language | eng | - |
dc.relation.ispartof | Current Oral Health Reports | - |
dc.subject | Apoptosis | - |
dc.subject | Degranulation | - |
dc.subject | Neutrophils | - |
dc.subject | Oral health | - |
dc.subject | Reactive oxygen species | - |
dc.title | Oral Polymorphonuclear Neutrophil Contributes to Oral Health | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/s40496-018-0199-6 | - |
dc.identifier.scopus | eid_2-s2.0-85075514319 | - |
dc.identifier.volume | 5 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 211 | - |
dc.identifier.epage | 220 | - |
dc.identifier.eissn | 2196-3002 | - |