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Article: Ultrasound-triggered interfacial engineering-based microneedle for bacterial infection acne treatment

TitleUltrasound-triggered interfacial engineering-based microneedle for bacterial infection acne treatment
Authors
Issue Date8-Mar-2023
PublisherAmerican Association for the Advancement of Science
Citation
Science Advances, 2023, v. 9, n. 10 How to Cite?
AbstractAcne is an inflammatory skin disease mainly caused by Propionibacterium acnes, which can cause local inflammatory reactions and develop into chronic inflammatory diseases in severe cases. To avoid the use of antibiotics and to effectively treat the site of acne, we report a sodium hyaluronate microneedle patch that mediates the transdermal delivery of ultrasound-responsive nanoparticles for the effective treatment of acne. The patch contains nanoparticles formed by zinc porphyrin–based metal-organic framework and zinc oxide (ZnTCPP@ZnO). We demonstrated activated oxygen-mediated killing of P. acnes with an antibacterial efficiency of 99.73% under 15 min of ultrasound irradiation, resulting in a decrease in levels of acne-related factors, including tumor necrosis factor–α, interleukins, and matrix metalloproteinases. The zinc ions up-regulated DNA replication–related genes, promoting the proliferation of fibroblasts and, consequently, skin repair. This research leads to a highly effective strategy for acne treatment through the interface engineering of ultrasound response.
Persistent Identifierhttp://hdl.handle.net/10722/337001
ISSN
2023 Impact Factor: 11.7
2023 SCImago Journal Rankings: 4.483
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXiang, YM-
dc.contributor.authorLu, JL-
dc.contributor.authorMao, CY-
dc.contributor.authorZhu, YZ-
dc.contributor.authorWang, CF-
dc.contributor.authorWu, J-
dc.contributor.authorLiu, XM-
dc.contributor.authorWu, SL-
dc.contributor.authorKwan, KYH-
dc.contributor.authorCheung, KMC-
dc.contributor.authorYeung, KWK-
dc.date.accessioned2024-03-11T10:17:15Z-
dc.date.available2024-03-11T10:17:15Z-
dc.date.issued2023-03-08-
dc.identifier.citationScience Advances, 2023, v. 9, n. 10-
dc.identifier.issn2375-2548-
dc.identifier.urihttp://hdl.handle.net/10722/337001-
dc.description.abstractAcne is an inflammatory skin disease mainly caused by Propionibacterium acnes, which can cause local inflammatory reactions and develop into chronic inflammatory diseases in severe cases. To avoid the use of antibiotics and to effectively treat the site of acne, we report a sodium hyaluronate microneedle patch that mediates the transdermal delivery of ultrasound-responsive nanoparticles for the effective treatment of acne. The patch contains nanoparticles formed by zinc porphyrin–based metal-organic framework and zinc oxide (ZnTCPP@ZnO). We demonstrated activated oxygen-mediated killing of P. acnes with an antibacterial efficiency of 99.73% under 15 min of ultrasound irradiation, resulting in a decrease in levels of acne-related factors, including tumor necrosis factor–α, interleukins, and matrix metalloproteinases. The zinc ions up-regulated DNA replication–related genes, promoting the proliferation of fibroblasts and, consequently, skin repair. This research leads to a highly effective strategy for acne treatment through the interface engineering of ultrasound response.-
dc.languageeng-
dc.publisherAmerican Association for the Advancement of Science-
dc.relation.ispartofScience Advances-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleUltrasound-triggered interfacial engineering-based microneedle for bacterial infection acne treatment-
dc.typeArticle-
dc.identifier.doi10.1126/sciadv.adf0854-
dc.identifier.scopuseid_2-s2.0-85149705453-
dc.identifier.volume9-
dc.identifier.issue10-
dc.identifier.eissn2375-2548-
dc.identifier.isiWOS:000960951400011-
dc.identifier.issnl2375-2548-

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