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Article: Application of silver nanoparticles for improving motor recovery after spinal cord injury via reduction of pro-inflammatory M1 macrophages

TitleApplication of silver nanoparticles for improving motor recovery after spinal cord injury via reduction of pro-inflammatory M1 macrophages
Authors
Issue Date9-May-2023
PublisherElsevier
Citation
Heliyon, 2023, v. 9, n. 5 How to Cite?
Abstract

Silver nanoparticles (AgNPs) possess anti-inflammatory activities and have been widely deployed for promoting tissue repair. Here we explored the efficacy of AgNPs on functional recovery after spinal cord injury (SCI). Our data indicated that, in a SCI rat model, local AgNPs delivery could significantly recover locomotor function and exert neuroprotection through reducing of pro-inflammatory M1 survival. Furthermore, in comparison with Raw 264.7-derived M0 and M2, a higher level of AgNPs uptake and more pronounced cytotoxicity were detected in M1. RNA-seq analysis revealed the apoptotic genes in M1 were upregulated by AgNPs, whereas in M0 and M2, pro-apoptotic genes were downregulated and PI3k-Akt pathway signaling pathway was upregulated. Moreover, AgNPs treatment preferentially reduced cell viability of human monocyte-derived M1 comparing to M2, supporting its effect on M1 in human. Overall, our findings reveal AgNPs could suppress M1 activity and imply its therapeutic potential in promoting post-SCI motor recovery.


Persistent Identifierhttp://hdl.handle.net/10722/337037
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLin, Jie-
dc.contributor.authorChen, Peikai-
dc.contributor.authorTan, Zhijia-
dc.contributor.authorSun, Yi-
dc.contributor.authorTam, Wai Kit-
dc.contributor.authorAo, Di-
dc.contributor.authorShen, Wei-
dc.contributor.authorLeung, Victor Yu-Leong-
dc.contributor.authorCheung, Kenneth Man Chee-
dc.contributor.authorTo, Michael Kai Tsun-
dc.date.accessioned2024-03-11T10:17:35Z-
dc.date.available2024-03-11T10:17:35Z-
dc.date.issued2023-05-09-
dc.identifier.citationHeliyon, 2023, v. 9, n. 5-
dc.identifier.urihttp://hdl.handle.net/10722/337037-
dc.description.abstract<p>Silver nanoparticles (AgNPs) possess anti-inflammatory activities and have been widely deployed for promoting tissue repair. Here we explored the efficacy of AgNPs on functional recovery after spinal cord injury (SCI). Our data indicated that, in a SCI rat model, local AgNPs delivery could significantly recover locomotor function and exert neuroprotection through reducing of pro-inflammatory M1 survival. Furthermore, in comparison with Raw 264.7-derived M0 and M2, a higher level of AgNPs uptake and more pronounced cytotoxicity were detected in M1. RNA-seq analysis revealed the apoptotic genes in M1 were upregulated by AgNPs, whereas in M0 and M2, pro-apoptotic genes were downregulated and PI3k-Akt pathway signaling pathway was upregulated. Moreover, AgNPs treatment preferentially reduced cell viability of human monocyte-derived M1 comparing to M2, supporting its effect on M1 in human. Overall, our findings reveal AgNPs could suppress M1 activity and imply its therapeutic potential in promoting post-SCI motor recovery.<br></p>-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofHeliyon-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleApplication of silver nanoparticles for improving motor recovery after spinal cord injury via reduction of pro-inflammatory M1 macrophages-
dc.typeArticle-
dc.identifier.doi10.1016/j.heliyon.2023.e15689-
dc.identifier.scopuseid_2-s2.0-85159150682-
dc.identifier.volume9-
dc.identifier.issue5-
dc.identifier.eissn2405-8440-
dc.identifier.isiWOS:001026401700001-
dc.identifier.issnl2405-8440-

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