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Article: Human immune repertoire in hepatitis B virus infection

TitleHuman immune repertoire in hepatitis B virus infection
Authors
Zhan, QXu, JHYu, YYLo, KNEFeliciannaEl-Nezami, HZeng, Z
KeywordsB-cell receptor
Chronic viral infection
Hepatitis B virus
High-throughput sequencing
Immune repertoire
T-cell receptor
Issue Date7-Jul-2021
PublisherBaishideng Publishing Group
Citation
World Journal of Gastroenterology, 2021, v. 27, n. 25, p. 3790-3801 How to Cite?
DOI: http://dx.doi.org/10.3748/wjg.v27.i25.3790
Abstract

Hepatitis B virus (HBV) infection is a public health threat that affects 257 million people worldwide and can progress to liver cirrhosis, liver failure, and hepatocellular carcinoma. The HBV antigen- induced adaptive immune response plays an important role in HBV clearance. Immune repertoire sequencing (IRS) has been used to investigate the molecular mechanisms behind the immune system, find novel ways to treat HBV infection, and evaluate the genetic responses and immune characteristics of individuals infected by HBV or immunized by HBV vaccine. This review summarizes the human immune repertoire analysis methodology, and the application of the IRS in the prediction of HBV infection progression, treatment, and vaccination.


Persistent Identifierhttp://hdl.handle.net/10722/337210
ISSN
1007-9327
2023 Impact Factor: 4.3
2023 SCImago Journal Rankings: 1.063
ISI Accession Number ID
WOS:000676275500007

 

DC FieldValueLanguage
dc.contributor.authorZhan, Q-
dc.contributor.authorXu, JH-
dc.contributor.authorYu, YY-
dc.contributor.authorLo, KNE-
dc.contributor.authorFelicianna-
dc.contributor.authorEl-Nezami, H-
dc.contributor.authorZeng, Z-
dc.date.accessioned2024-03-11T10:18:56Z-
dc.date.available2024-03-11T10:18:56Z-
dc.date.issued2021-07-07-
dc.identifier.citationWorld Journal of Gastroenterology, 2021, v. 27, n. 25, p. 3790-3801-
dc.identifier.issn1007-9327-
dc.identifier.urihttp://hdl.handle.net/10722/337210-
dc.description.abstract<p>Hepatitis B virus (HBV) infection is a public health threat that affects 257 million people worldwide and can progress to liver cirrhosis, liver failure, and hepatocellular carcinoma. The HBV antigen- induced adaptive immune response plays an important role in HBV clearance. Immune repertoire sequencing (IRS) has been used to investigate the molecular mechanisms behind the immune system, find novel ways to treat HBV infection, and evaluate the genetic responses and immune characteristics of individuals infected by HBV or immunized by HBV vaccine. This review summarizes the human immune repertoire analysis methodology, and the application of the IRS in the prediction of HBV infection progression, treatment, and vaccination.<br></p>-
dc.languageeng-
dc.publisherBaishideng Publishing Group-
dc.relation.ispartofWorld Journal of Gastroenterology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectB-cell receptor-
dc.subjectChronic viral infection-
dc.subjectHepatitis B virus-
dc.subjectHigh-throughput sequencing-
dc.subjectImmune repertoire-
dc.subjectT-cell receptor-
dc.titleHuman immune repertoire in hepatitis B virus infection-
dc.typeArticle-
dc.identifier.doi10.3748/wjg.v27.i25.3790-
dc.identifier.scopuseid_2-s2.0-85111951719-
dc.identifier.volume27-
dc.identifier.issue25-
dc.identifier.spage3790-
dc.identifier.epage3801-
dc.identifier.eissn2219-2840-
dc.identifier.isiWOS:000676275500007-
dc.identifier.issnl1007-9327-

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